Results 71 to 80 of about 2,293,512 (363)

3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology

Advanced Functional Materials, EarlyView.
Glioblastoma multiforme is the most devastating and incurable brain tumor. To better study this disease, a 3D model is developed using a hyaluronic acid‐based hydrogel combined with a multicellular approach. This model recapitulates in vivo brain stiffness, cell‐extracellular matrix and cell‐cell interactions and the tumor's hijacking function with the
Mateo S. Andrade Mier, Esra Türker, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Panthipa Suwannakot, Benedikt Gantert, Abhinav Singh, Vanessa Moessler, Annemarie Sodmann, Nicoletta Murenu, Joachim Schenk, Natascha Schaefer, Torsten Blunk, Aldo R. Boccaccini, Tessa C. Lühmann, Jörg Tessmar, Jeremy M. Crook, Eva Tomaskovic‐Crook, Paul D. Dalton, Gregor Lang, Robert Blum, Reiner Strick, Silvia Budday, Katrin G. Heinze, Carmen Villmann   +26 more
wiley   +1 more source

A gain‐of‐function GRIA2 variant associated with neurodevelopmental delay and seizures: Functional characterization and targeted treatment

Epilepsia, Volume 63, Issue 12, Page e156-e163, December 2022., 2022
Abstract α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid‐type glutamate receptors (AMPARs) are ligand‐gated cationic channels formed from combinations of GluA1‐4 subunits. Pathogenic variants of GRIA1–4 have been described in patients with developmental delay, intellectual disability, autism spectrum disorder, and seizures, with GRIA2 variants ...
Ian D. Coombs, Julie Ziobro, Volodymyr Krotov, Taryn‐Leigh Surtees, Stuart G. Cull‐Candy, Mark Farrant   +5 more
wiley   +1 more source

Structure and function of AMPA receptors [PDF]

The Journal of Physiology, 2004
The application of X‐ray diffraction has allowed the structure of the ligand‐binding core of AMPA receptors to be determined. Here I review the insights that this has given into the molecular mechanisms of activation and desensitization of these receptors.
openaire   +3 more sources

The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex

eLife, 2023
Intracellular trafficking of AMPA receptors is a tightly regulated process which involves several adaptor proteins, and is crucial for the activity of excitatory synapses both in basal conditions and during synaptic plasticity.
Edoardo Moretto, Federico Miozzo, Anna Longatti, Caroline Bonnet, Francoise Coussen, Fanny Jaudon, Lorenzo A Cingolani, Maria Passafaro   +7 more
doaj   +1 more source

Estimating the synaptic current in a multi-conductance AMPA receptor model [PDF]

, 2010
A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal that may generate an action potential.
arxiv   +1 more source

D2HGDH Deficiency Regulates Seizures through GSH/Prdx6/ROS‐Mediated Excitatory Synaptic Activity

Advanced Science, EarlyView.
Downregulating D‐2‐hydroxyglutarate dehydrogenase (D2HGDH) increases epilepsy susceptibility by altering reactive oxygen species (ROS) levels and synaptic function, contributing to oxidative stress in neurons. The acid calcium‐independent phospholipase A2 (aiPLA2) inhibitor MJ33 restores glutathione reduced/glutathione oxidized balance, reducing ROS ...
Zhijuan Zhang, Hui Zhang, Peng Zhang, Rong Li, Jinyu Zhou, Jiyuan Li, Danmei Hu, Rui Huang, Fenglin Tang, Jie Liu, Demei Xu, Chenlu Zhang, Xin Tian, Yuanlin Ma, Patrick Kwan   +14 more
wiley   +1 more source

Residence times of receptors in dendritic spines analyzed by simulations in empirical domains [PDF]

, 2014
Analysis of high-density superresolution imaging of receptors reveal the organization of dendrites at the nano-scale resolution. We present here simulations in empirical live cell images, which allows converting local information extracted from short range trajectories into simulations of long range trajectories.
arxiv   +1 more source

An Analytically Solvable Model of Firing Rate Heterogeneity in Balanced State Networks [PDF]

arXiv, 2023
Distributions of neuronal activity within cortical circuits are often found to display highly skewed shapes with many neurons emitting action potentials at low or vanishing rates, while some are active at high rates. Theoretical studies were able to reproduce such distributions, but come with a lack of mathematical tractability, preventing a deeper ...
arxiv  

Large number of receptors may reduce cellular response time variation [PDF]

Physical biology 10 (3), 035008, 2013, 2012
Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv   +1 more source

Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top–Down Circuit

Advanced Science, EarlyView.
The anterior piriform cortex (APC) exhibits distinct neural firings and calcium transients in response to familiar and novel mice, with a more robust response to the novel one. Selectively inhibiting APC pyramidal neurons disrupt social novelty recognition without impairing basic odor discrimination.
Jingwei Zhou, Zhaoyang Yin, Zhiyun Chen, Hanyu Fu, Qun Li, Shan Li, Ying Zhang, Xianzhi Zhang, Dewei Tang, Anan Li, Dejuan Wang   +10 more
wiley   +1 more source