Results 101 to 110 of about 543,609 (231)

Neuronal and psychological underpinnings of pathological gambling [PDF]

, 2014
Like in the case of drugs, gambling hijacks reward circuits in a brain which is not prepared to receive such intense stimulation. Dopamine is normally released in response to reward and uncertainty in order to allow animals to stay alive in their ...
Anselme, Bryan F. Singer, Clark, Goudriaan, Kalkhoven, Lawrence, Li, Linnet, Mike J. F. Robinson, Paglieri, Patrick Anselme, Paul Vezina, Porchet, Potenza, Singer, Tedford, van den Bos, Zack, Zack   +18 more
core   +3 more sources

A meta‐analysis of sexual orientation inequities in substance use among youth

Addiction, EarlyView.
Abstract Background and Aims Sexual minority youth report significantly higher rates of substance use than heterosexual youth, yet a comprehensive and systematic evaluation and synthesis of the magnitude of this inequity has not been conducted. The purpose of this study was to conduct a meta‐analysis to assess the magnitude of overall inequities in ...
Ethan H. Mereish, Hyemin Lee, Jeremy T. Goldbach, Sophie Hathaway, Emily A. Hennessy   +4 more
wiley   +1 more source

Peripheral vascular manifestation in patients receiving an amphetamine analog: A case series

Vascular Medicine, 2018
Amphetamine and its related derivatives and analogues (ADRA) are highly addictive central nervous system stimulants that are used commonly in the treatment of attention-deficit/hyperactivity disorder and narcolepsy.
GuangMing Tan, Ari J. Mintz, B. Mintz, J. Borges, Mary Deborah Hines, R. Schainfeld, M. Jaff, I. Weinberg   +7 more
semanticscholar   +1 more source

CST, an Herbal Formula, Exerts Anti-Obesity Effects through Brain-Gut-Adipose Tissue Axis Modulation in High-Fat Diet Fed Mice

Molecules, 2016
The brain, gut, and adipose tissue interact to control metabolic pathways, and impairment in the brain-gut-adipose axis can lead to metabolic disorders, including obesity.
AbuZar Ansari, Shambhunath Bose, Mukesh Kumar Yadav, Jing-Hua Wang, Yun-Kyung Song, Seong-Gyu Ko, Hojun Kim   +6 more
doaj   +1 more source

Single prazosin infusion in prelimbic cortex Fosters extinction of amphetamine-induced conditioned place preference [PDF]

, 2017
Exposure to drug-associated cues to induce extinction is a useful strategy to contrast cue-induced drug seeking. Norepinephrine (NE) transmission in medial prefrontal cortex has a role in the acquisition and extinction of conditioned place preference ...
Alessandro Rava, Emanuele C. Latagliata, Giulia Chiacchierini, Luisa Lo Iacono, Luisa Lo Iacono, Marco Sancandi, Stefano Puglisi-Allegra, Stefano Puglisi-Allegra, Valeria Oliva   +8 more
core   +4 more sources

Trends in fentanyl‐containing drug samples seized by law enforcement agencies across Canada

Addiction, EarlyView.
Abstract Background and aims Canada's drug toxicity crisis has been largely attributed to a volatile fentanyl‐dominated unregulated drug supply with increasing reports of fentanyl detected in combination with benzodiazepines, stimulants and xylazine.
Shaleesa Ledlie, Ria Garg, Pamela Leece, Gillian Kolla, Elaine Hyshka, Mina Tadrous, Tara Gomes   +6 more
wiley   +1 more source

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

Addiction, EarlyView.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu, Chia‐Chun Hung, Marc N. Potenza, Kun‐Hsien Chou, Pei‐Lin Lee, Chu‐Chung Huang, Chiang‐Shan R. Li, Tony Szu‐Hsien Lee, Ching‐Po Lin   +8 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Performance deficits of NK1 receptor knockout mice in the 5 choice serial reaction time task: effects of d Amphetamine, stress and time of day. [PDF]

, 2011
Background The neurochemical status and hyperactivity of mice lacking functional substance P-preferring NK1 receptors (NK1R-/-) resemble abnormalities in Attention Deficit Hyperactivity Disorder (ADHD).
A Blokland, A Castañé, AA Harrison, AJ Mayorga, AS Fisher, BJ Cole, C De Felipe, C Orsini, CA Winstanley, CA Winstanley, CJ Vaidya, David N. Stephens, DE May, DJ Heal, E Calcagno, Ewelina M. Grabowska, EY Pioli, F Pollier, FX Castellanos, G Aston-Jones, G Mick, G Polanczyk, G Renoldi, GA Higgins, H Caci, HD Piggins, I Herpfer, I Tsutsui-Kimura, JA Milstein, JL Evenden, JM Finlay, Julia A. Dudley, JW Dalley, JW Dalley, K Schwabe, KJ Anderson, KJ Radonovich, L Bizarro, L Bizarro, M Carli, M Pum, ME Toplak, MH Teicher, MM Van Veen, N Froger, N Singewald, NM De Bruin, R Kuczenski, R Tannock, RD Oades, RE Mattison, RL Gannon, Ruth K. Weir, S Bejerot, S Body, S Houghton, S Houghton, S Patel, S. Clare Stanford, SC Wood, SI Sharp, SJ Yang, Stephen P. Hunt, T Humby, T Koskinen, T Sagvolden, Tamzin L. Ripley, TC Yan, TC Yan, Ting Carrie Yan, Warren H. Meck, X Xu, Yolanda Peña-Oliver, YP Oliver   +73 more
core   +3 more sources

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source