Results 81 to 90 of about 13,097,347 (378)

Amphotericin B: delivery systems [PDF]

Antimicrobial Agents and Chemotherapy, 1990
Because the clinical utility of amphotericin B (AmB) is limited by its toxicity of host cells, an important question is how to best direct it specifically to the fungus or at least to the site of infection or, alternatively, how to keep it away from the host cells. One strategy is to use a vehicle other than deoxycholate.
Gerald Medoff, Janina Brajtburg, George S. Kobayashi, William G. Powderly   +3 more
openaire   +3 more sources

Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases

Advanced Materials, EarlyView.
This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu, Rockie Haiyao Ding, Zixuan Zhao, Clara Yieh Lin Chong, Ruochii You, Hengjia Zhou, Dong Hua Seah, Wei Qiang Leow, Hong Kit Lim, Sukanya Shyamasundar, Kanishka Fernando, Fathima Farzana Kuthubudeen, Gillian Ng, Chor Yong Tay, Narayanan Gopalakrishna Iyer, Chin‐Ann Johnny Ong, Eliza Li Shan Fong   +16 more
wiley   +1 more source

Delayed results of treatment of paracoccidioidomycosis with amphotericin B plus sulfamides versus amphotericin B alone

Revista do Instituto de Medicina Tropical de São Paulo, 1986
A delayed evaluation of two groups of patients with paracoccidioidomycosis was carried out. Both groups were treated with amphotericin B, "but one of them was submitted to maintenance treatment with sulfonamides.
Neuza Lima Dillon, Sebastião A. P. Sampaio, Marta Cassoni Habermann, Silvio Alencar Marques, Joel Carlos Lastória, Hamilton Ometto Stolf, Nilson Camargo de Andrade Selva, Paulo Roberto Curi   +7 more
doaj   +1 more source

Two cases of fungal keratitis caused by Metarhizium anisopliae [PDF]

, 2018
We present two cases of keratitis due to Metarhizium anisopliae in geographically separated areas of the United States. The isolates were microscopically similar but morphologically different and were identified by ribosomal DNA sequencing. Both isolates
Burd, Eileen M, Burnham, Carey-Ann D, Goodman, Abigail L, Lockhart, Shawn R, Lysen, Colleen B, Westblade, Lars F   +5 more
core   +2 more sources

In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms.

Journal of Antimicrobial Chemotherapy, 2015
OBJECTIVES Biofilm formation by Candida albicans poses an important therapeutic challenge in human diseases. Typically, conventional antifungal agents encounter difficulty in treating and fully eradicating biofilm-related infections.
A. Katragkou, M. McCarthy, Elizabeth L. Alexander, C. Antachopoulos, J. Meletiadis, M. Jabra-Rizk, V. Petraitis, E. Roilides, T. Walsh   +8 more
semanticscholar   +1 more source

Traceless Photopolymerization with Non‐Pulsed Red Light Enables 3D‐Printable Cell‐Laden Hydrogels

Advanced Materials, EarlyView.
The paper presents a red‐light‐induced polymerization process, initiated by the FDA‐approved dye methylene blue and the cytocompatible co‐initiator triethanolamine, for fabricating hydrogels. This photopolymerization process is oxygen‐tolerant, cytocompatible, and, most importantly, leaves no color traces, resulting in completely transparent scaffolds.
Ali Eftekhari, Kelsey Rianne de Graaf, Ekaterina Takmakova, Hatai Jongprasitkul, Alexander Efimov, Sanna Turunen, Andrew Kerr, Minna Kellomäki, Robert Luxenhofer, Timo Laaksonen, Nikita Durandin   +10 more
wiley   +1 more source

Solid‐State NMR Reveals Reorganization of the Aspergillus fumigatus Cell Wall Due to a Host‐Defence Peptide

Angewandte Chemie, EarlyView.
Understanding the mode of action is critical to develop new antifungal drugs. Solid‐state NMR was used to study the reorganization of the Aspergillus fumigatus cell wall by a host‐defence peptide. We identified specific polysaccharides and amino acids that are affected by the peptide.
Ajit Kumar Bishoyi, Jacq van Neer, Salima Bahri, Sophie Lorenz, Hans de Cock, Marc Baldus   +5 more
wiley   +2 more sources

Nebulised amphotericin B to eradicate Candida colonisation from the respiratory tract in critically ill patients receiving selective digestive decontamination: a cohort study [PDF]

, 2013
INTRODUCTION: Colonisation of the lower respiratory tract with Candida species occurs in 25% of mechanically ventilated critically ill patients, and is associated with increased morbidity.
Cristian Spitoni, David SY Ong, Marc JM Bonten, Olaf L Cremer, Peter MC Klein Klouwenberg   +4 more
core   +1 more source

Stimulation of Monocytes, Macrophages, and Microglia by Amphotericin B and Macrophage Colony-Stimulating Factor Promotes Remyelination

Journal of Neuroscience, 2015
Approaches to stimulate remyelination may lead to recovery from demyelinating injuries and protect axons. One such strategy is the activation of immune cells with clinically used medications, since a properly directed inflammatory response can have ...
A. Döring, S. Sloka, Lorraine Lau, M. Mishra, J. van Minnen, Xu Zhang, D. Kinniburgh, S. Rivest, V. Yong   +8 more
semanticscholar   +1 more source

Thermal Annealing Enhances Piezoelectricity and Regenerative Potential of PVDF‐TrFE Nanofiber Scaffolds

Advanced Materials Technologies, EarlyView.
Thermal annealing improves the structure, stiffness, and piezoelectric properties of poly(vinylidene flouride‐trifluoroethylene) (PVDF‐TrFE) nanofiber scaffolds. These annealed scaffolds promote Schwann cell proliferation and matrix remodeling in vitro and demonstrate in vivo biocompatibility.
Maksym Krutko, Holly M. Poling, Maulee Sheth, Supasek Kongsomros, Andrew E. Bryan, Manju Sharma, Akaljot Singh, Hasan A. Reza, Kathryn A. Wikenheiser‐Brokamp, Takanori Takebe, Michael A. Helmrath, Greg M. Harris, Leyla Esfandiari   +12 more
wiley   +1 more source