Results 221 to 230 of about 228,730 (331)

Metformin-Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention. [PDF]

Cancer Med
Jinadasa AGRG, Wageesha NDA, Samarakoon SR, Ekanayake S, Akalanka HMK.   +4 more
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways. [PDF]

Front Pharmacol
Peng J, Ou Y, Zhou M, Wang X, Zhang X, Long H, Wu G, Che M, Li K, Yang L, Zhang Z, Yung KKL, Qi S, Feng Z.   +13 more
europepmc   +1 more source

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells

International Journal of Cancer, EarlyView.
What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Saha   +9 more
wiley   +1 more source

CircZBTB46 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miRNA-326/FGF1 axis. [PDF]

Cell Death Discov
Zeng QM, Hu T, Jiang W, Teng X, Wu D, Tang H, Liu CH.   +6 more
europepmc   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

SGPP2 Ameliorates Chronic Heart Failure by Attenuating ERS via the SIRT1/AMPK Pathway. [PDF]

Curr Issues Mol Biol
Kang Y, Wang Y, Wang L, Fu L.
europepmc   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Acute Cold Exposure Cell-Autonomously Reduces mTORC1 Signaling and Protein Synthesis Independent of AMPK. [PDF]

Cells
Sung BY, Ford EJ, Foster DJ, Fullmer KJ, Cromwell C, Viollet B, Thomson DM.   +6 more
europepmc   +1 more source