Results 61 to 70 of about 228,730 (331)
AMP-activated protein kinase: a therapeutic target in intestinal diseases [PDF]
Open Biology, 2017 Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders.
Xiaofei Sun, Mei-Jun Zhu
doaj +1 more source
The Journal of Poultry Science, 2022 Protein synthesis in skeletal muscle is considered one of the most energy-consuming cellular processes. AMP-activated protein kinase (AMPK) is a metabolic master switch that regulates glucose and lipid metabolism, and it is implicated in protein ...
Kazuki Nakashima, Aiko Ishida
doaj +1 more source
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer [PDF]
, 2019 BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC).
Díaz Moreno, Irene +4 more
core +1 more source
Metformin limits osteoarthritis development and progression through activation of AMPK signalling
Annals of the Rheumatic Diseases, 2020 Objectives In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression. Methods Destabilisation of the medial meniscus (DMM) surgery was performed in 10-week-old wild type and AMP-activated protein kinase
Jun Li +15 more
semanticscholar +1 more source
AMPK in the brain: its roles in glucose and neural metabolism
The FEBS Journal, 2021 The adenosine monophosphate‐activated protein kinase (AMPK) is an integrative metabolic sensor that maintains energy balance at the cellular level and plays an important role in orchestrating intertissue metabolic signaling. AMPK regulates cell survival,
Ranjithmenon Muraleedharan, B. Dasgupta
semanticscholar +1 more source
Oncotarget, 2015 AMP-activated protein kinase (AMPK) is an evolutionarily conserved heterotrimeric complex composed of α (catalytic α1 and α2) and β/γ (regulatory β1, β2, γ1, γ2, and γ3) subunits and serves as a gatekeeper of energy metabolism by responding to metabolic needs of a cell.
Takafumi, Miyamoto +2 more
openaire +2 more sources
A new duet in cancer biology: AMPK the typical and UBE2O the atypical
Molecular & Cellular Oncology, 2017 Ubiquitin-conjugating enzyme E2O (UBE2O) is upregulated in human cancers. We have demonstrated that genetic deletion or pharmacological blockade of UBE2O reduces tumorigenesis through inhibiting the mammalian target of rapamycin complex 1–hypoxia ...
Isabelle K. Vila +2 more
doaj +1 more source
Food & Nutrition Research, 2022 Background: Obesity is a global public health concern and increases the risk of metabolic syndrome and other diseases. The anti-obesity effects of various plant-derived bioactive compounds, such as tea extracts, are well-established.
Ruohong Chen +10 more
doaj +1 more source
Glutamate induces autophagy via the two-pore channels in neural cells [PDF]
, 2016 NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2.
+11 more
core +4 more sources
Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter
Nature Communications, 2022 AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics which coordinates metabolism by phosphorylating a plethora of substrates throughout the cell.
Danielle L. Schmitt +8 more
semanticscholar +1 more source