Results 91 to 100 of about 12,396 (213)

Loss of Beta‐Cell Identity and Function as a Mechanism of Secondary Failure of Sulfonylurea Therapy in Diabetes

MedComm, Volume 7, Issue 2, February 2026.
ABSTRACT Sulfonylureas, commonly used to treat type 2 diabetes (T2D), often lose effectiveness over time when used as monotherapy; however, the underlying mechanisms remain unclear. To investigate the mechanisms of sulfonylurea failure, glibenclamide‐releasing pellets were implanted in KK mice, a polygenic model that spontaneously develops T2D. KK mice
Sumit Patel, Zihan Yan, Maria S. Remedi
wiley   +1 more source

Baseline characteristics in the SYNCHRONIZE™‐2 randomized phase 3 trial of survodutide, a glucagon receptor/GLP‐1 receptor dual agonist, for obesity in people with type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1490-1498, February 2026.
Abstract Aims Survodutide is an investigational glucagon receptor/glucagon‐like peptide‐1 receptor dual agonist that has shown promise for treating obesity and its complications in Phase 2 trials. Two double‐blind, randomized, global Phase 3 trials are designed to assess the efficacy and safety of survodutide for treatment of obesity—SYNCHRONIZE™‐1 in ...
Sean Wharton, Carel W. le Roux, Biykem Bozkurt, Elke Platz, Gabriele Bleckert, Samina Ajaz Hussain, Martina Brueckmann, Elena Startseva, Isabel M. Kloer, Lee M. Kaplan   +9 more
wiley   +1 more source

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

Journal of Neuroinflammation, 2017
Background Neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer’s disease (AD) pathology.
Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David MacTavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamandas   +8 more
doaj   +1 more source

Amylin [PDF]

, 2020
Chia-Lin Chuang, Debbie L. Hay
openaire   +2 more sources

Construction and Identification of a Breast Bioreactor for Human-Derived Hypoglycemic Protein Amylin

Life
The mammary gland of mammals can generate numerous bioactive proteins. To express the human amylin protein in the mammary glands of domestic animals, we engineered a transgenic mammary gland bioreactor. For this study, we produced transgenic mice through
Kongwei Huang, Xiuying Yan, Zhipeng Li, Fuhang Liu, Kuiqing Cui, Qingyou Liu   +5 more
doaj   +1 more source

Amylin in the Periphery II: An Updated Mini-Review

The Scientific World Journal, 2006
Amylin is a polypeptide that is cosecreted with insulin from the β cells of the pancreas. Therefore, in states of diabetes in which the β-cell mass is largely depleted or dysfunctional, insulin and amylin secretion are also lost or dysregulated.While the
Peter J. Wookey, Thomas A. Lutz, Sof Andrikopoulos   +2 more
doaj   +1 more source

Interaction of amylin species with transition metals and membranes.

Journal of Inorganic Biochemistry, 2019
Islet Amyloid Polypeptide (IAPP), also known as amylin, is a 37-amino-acid peptide hormone that is secreted by pancreatic islet β-cells. Amylin is complementary to insulin in regulating and maintaining blood glucose levels in the human body.
Mawadda Alghrably, Iwona Czaban, Łukasz Jaremko, Mariusz Jaremko   +3 more
semanticscholar   +1 more source

Varicella Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-beta, and an Amyloidogenic Extracellular Environment.

Journal of Infectious Diseases, 2019
BACKGROUND Herpes zoster is linked to amyloid-associated diseases, including dementia, macular degeneration, and diabetes mellitus, in epidemiological studies.
Andrew N Bubak, Christina N. Como, C. Coughlan, Noah R. Johnson, James E. Hassell, T. Mescher, Christy S. Niemeyer, R. Mahalingam, R. Cohrs, Timothy D. Boyd, H. Potter, H. Russ, M. Nagel   +12 more
semanticscholar   +1 more source

Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological Actions

The Scientific World Journal, 2001
CGRP, AM, amylin, and CT have in common N-terminal 6-7 amino acid ring structures linked by disulfide bridges and amidated C-termini required for biological activity.
J.A. Fischer, W. Born, R. Muff
doaj   +1 more source

Exploring the central region of amylin and its analogs aggregation: the influence of metal ions and residue substitutions

Frontiers in Chemistry
Human amylin (hIAPP) is found in the form of amyloid deposits within the pancreatic cells of nearly all patients diagnosed with type 2 diabetes mellitus (T2DM).
Mawadda Alghrably, Giulia Bennici, Gabriela Szczupaj, Gabriela Szczupaj, Noura Alasmael, Somayah Qutub, Batoul Maatouk, Kousik Chandra, Michal Nowakowski, Abdul-Hamid Emwas, Mariusz Jaremko   +10 more
doaj   +1 more source