Results 151 to 160 of about 12,396 (213)

A structural basis for amylin receptor phenotype

Science, 2022
Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of three receptor activity–modifying proteins (RAMPs), AMY1R, AMY2R, and AMY3R.
Jianjun Cao, Matthew J Belousoff, Yi-Lynn Liang   +2 more
exaly   +2 more sources

Amylin as a potential link between type 2 diabetes and alzheimer disease

Annals of Neurology, 2019
Alzheimer disease (AD) is the leading cause of dementia, and although its etiology remains unclear, it seems that type 2 diabetes mellitus (T2DM) and other prediabetic states of insulin resistance could contribute to the appearance of sporadic AD.
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Mario Riverol   +2 more
exaly   +2 more sources

Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly

Nature Structural and Molecular Biology, 2020
Rodrigo U Gallardo, Matthew G Iadanza, Yong Xu   +2 more
exaly   +2 more sources

Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity

Cardiology in Review, 2023
Despite the worldwide epidemic of obesity, there remain few approved pharmacological treatment options to bridge the gap between lifestyle therapy and bariatric surgery.
Antonella M D'Ascanio, J. Mullally, W. Frishman   +2 more
semanticscholar   +1 more source

Amylin modulates a VTA to mPFC circuit to suppress food intake and impulsive food-directed behavior.

Biological Psychiatry, 2023
BACKGROUND A better understanding of the neural mechanisms regulating impaired satiety to palatable foods is essential to treat hyperphagia linked with obesity.
Caroline E. Geisler, Léa Décarie-Spain, Maxine K. Loh, Wolf Trumbauer, Jane Gaisinsky, Molly E. Klug, Caitlyn M Pelletier, Jon F. Davis, H. Schmidt, M. Roitman, S. Kanoski, M. R. Hayes   +11 more
semanticscholar   +1 more source

Long-acting amylin analogues for the management of obesity

Current Opinion in Endocrinology, Diabetes & Obesity, 2022
Purpose of review To summarize recent developments of long-acting amylin analogues for the treatment of obesity and to outline their mode of action.
David S Mathiesen, J. Bagger, F. Knop
semanticscholar   +1 more source

Amylin

Life Sciences, 1992
Amylin is a 37 amino-acid peptide which is secreted from the pancreatic islets of Langerhans. It has major sequence homology with calcitonin gene related peptide. Amylin can precipitate out in these cells to form amyloid. Amylin is secreted by similar stimuli to those that secrete insulin.
B J, Edwards, J E, Morley
openaire   +2 more sources

Clinical Implications of Amylin and Amylin Deficiency

The Diabetes Educator, 1999
PURPOSE this paper presents an overview of the physiology of glycemic control and the mechanisms of amylin deficiency in people with diabetes. Benefits of replacement therapy with both pramlintide and insulin are discussed. METHODS The discovery of the pancreatic p-cell hormone amylin, which is cosecreted with insulin in response to hyperglycemia ...
D F, Kruger, P M, Gatcomb, S K, Owen
openaire   +2 more sources

Amylin antibodies frequently display cross-reactivity with CGRP: characterization of eight amylin antibodies.

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2021
Amylin is a 37 amino acid endocrine hormone secreted from the pancreas in response to nutrient intake, acting centrally to promote meal ending satiation.
Tayla A. Rees, D. Hay, C. Walker
semanticscholar   +1 more source