Results 71 to 80 of about 12,396 (213)

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Copper(ii)–human amylin complex protects pancreatic cells from amylin toxicity [PDF]

Physical Chemistry Chemical Physics, 2013
Human amylin-derived oligomers and aggregates are believed to play an important role in the pathogenesis of type II diabetes mellitus (T2DM). In addition to amylin-evoked cell attrition, T2DM is often accompanied by elevated serum copper levels. Although previous studies have shown that human amylin, in the course of its aggregation, produces hydrogen ...
Elizabeth C, Lee, Emmeline, Ha, Sanghamitra, Singh, Linda, Legesse, Sana, Ahmad, Elena, Karnaukhova, Robert P, Donaldson, Aleksandar M, Jeremic   +7 more
openaire   +2 more sources

胰淀素在肥胖相关性肾病进展中的作用

Zhongguo shiyan zhenduanxue, 2011
目的探讨胰淀素（amylin）在肥胖相关性肾病（ORG）发展过程中的作用。方法 14例经肾活检证实的ORG患者为观察组（ORG组）,选择同期经肾活检确诊为系膜增生性肾小球肾炎患者作为相关疾病对照组（NC）。20只Wis-tar大鼠,高脂饮食诱导ORG大鼠模型,成模后随机均分为模型对照组（NC）和Amylin组（Amylin）。采用ELISA法检测血清amylin;放射免疫法检测胰岛素水平;自动生化分析仪测定血糖、血脂;考马斯亮蓝方法检测24小时尿蛋白定量;免疫组化法检测肾小球内amylin的表达。结果 ...
刘声茂, 崔英春, 田向辉, 顾华, 吴曼, 刘庆鑫, 张冬梅   +6 more
doaj  

Single Cell Analysis Reveals the Presence of Novel Intermediate Cells in Both Mice and Patients With Severe MASLD

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Schematic overview of the experimental workflow combining single‐cell RNA sequencing and spatial proteomics in a murine model of MASLD. Tissues were isolated, dissociated, and processed for single‐cell transcriptomic profiling to identify distinct cellular clusters and define cell‐type–specific gene expression signatures. Computational analysis enabled
Marica Meroni, Paride Pelucchi, Erika Paolini, Miriam Longo, Ada Sula, Michele Battistin, Alice Chiodi, Deborah Mattinzoli, Masami Ikehata, Elena Trombetta, Daniele Dondossola, Alessandra Mezzelani, Gianluca Martino Tartaglia, Giuseppe Castellano, Anna Ludovica Fracanzani, Flora Peyvandi, Stefano Gatti, Ettore Mosca, Paola Dongiovanni   +18 more
wiley   +1 more source

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

Communications Biology, 2023
Converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology in Alzheimer’s disease brains.
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa   +25 more
doaj   +1 more source

Copper(II) and Amylin Analogues: A Complicated Relationship.

Inorganic Chemistry, 2020
Protein aggregation has attracted substantial interest because of its role in causing many serious illnesses, such as neurodegenerative diseases and type II diabetes.
Mawadda Alghrably, D. Dudek, Abdul-Hamid M. Emwas, Łukasz Jaremko, Mariusz Jaremko, M. Rowińska-Żyrek   +5 more
semanticscholar   +1 more source

CBP/β‐Catenin Signaling in Hepatocytes Plays Pivotal Roles in MMP‐7‐Mediated Liver Fibrosis in a Metabolic Dysfunction‐Associated Steatohepatitis Mouse Model

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CDAHFD‐induced hepatic steatosis stimulates CBP/β‐catenin signaling in hepatocytes, leading to increased production of the downstream effector MMP‐7. Hepatocyte‐derived MMP‐7 contributes to fibrogenic responses and is associated with the progression of liver fibrosis.
Jun Imamura, Masamichi Kimura, Yumi Otoyama, Koji Nishikawa, Michinori Kohara, Kiminori Kimura   +5 more
wiley   +1 more source

Protein aggregates and proteostasis in aging: Amylin and β-cell function.

Mechanisms of Ageing and Development, 2019
The ubiquitin-proteasomal-system (UPS) and the autophagy-lysosomal-system (ALS) are both highly susceptible for disturbances leading to the accumulation of cellular damage.
M. Press, Tobias Jung, Jeannette König, T. Grune, A. Höhn   +4 more
semanticscholar   +1 more source

The Voice of a Disease: Why Food Noise Can No Longer Be Ignored!

Obesity, EarlyView.
Abdulhameed Alhazmi, Carel W. le Roux
wiley   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1622-1637, March 2026.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source