Results 81 to 90 of about 12,396 (213)

d -Retro Inverso Amylin and the Stability of Amylin Fibrils

Journal of Chemical Theory and Computation, 2020
Motivated by the role that amylin aggregates play in type-II diabetes, we compare the stability of regular amylin fibrils with the stability of fibrils where l-amino acid chains are replaced by d-retro inverso (DRI) amylin, that is, peptides where the sequence of amino acids is reversed, and at the same time, the l-amino acids are replaced by their ...
Preeti Pandey, Natalie Nguyen, Ulrich H.E. Hansmann   +2 more
openaire   +3 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

'Amylin' hormone [PDF]

Nature, 1989
C, Betsholtz, K H, Johnson, P, Westermark   +2 more
openaire   +4 more sources

Zn(II) binding to pramlintide results in a structural kink, fibril formation and antifungal activity

Scientific Reports, 2022
The antimicrobial properties of amylin, a 37-amino acid peptide hormone, co-secreted with insulin from the pancreas, are far less known than its antidiabetic function.
Dorota Dudek, Emilia Dzień, Joanna Wątły, Agnieszka Matera-Witkiewicz, Aleksandra Mikołajczyk, Agata Hajda, Joanna Olesiak-Bańska, Magdalena Rowińska-Żyrek   +7 more
doaj   +1 more source

Analysis of Amylin Consensus Sequences Suggests that Human Amylin is Not Optimized to Minimize Amyloid Formation and Provides Clues to Factors that Modulate Amyloidogenicity.

ACS Chemical Biology, 2020
The neuropancreatic polypeptide hormone amylin forms pancreatic islet amyloid in type-2 diabetes. Islet amyloid formation contributes to β-cell death in the disease and to the failure of islet transplants, but the features which influence amylin ...
Daeun Noh, Rebekah L. Bower, D. Hay, A. Zhyvoloup, D. Raleigh   +4 more
semanticscholar   +1 more source

Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Whey proteins possess antimicrobial and prebiotic properties that modulate gut microbiota by promoting beneficial bacteria like Bifidobacterium while suppressing pathogens. This modulation enhances short‐chain fatty acid production and strengthens intestinal barrier integrity, potentially alleviating dysbiosis‐related conditions such as colitis and ...
Tolulope Joshua Ashaolu, Chi‐Ching Lee, Ozgur Tarhan, Ali Rashidinejad, Seid Mahdi Jafari   +4 more
wiley   +1 more source

Human Amylin as a Novel Diagnostic Marker for Hypothyroidism in Iraqi Patients

مجلة بغداد للعلوم
Amylin is a peptide hormone that the pancreas cell secretes along with insulin.  As a neuroendocrine hormone that sends a specific signal to the brain, amylin is essential for maintaining homeostasis in the metabolism.
Duha Khalil Ibrahim, layla othman
doaj   +1 more source

Noradrenaline signaling in the LPBN mediates amylin's and salmon calcitonin's hypophagic effect in male rats

The FASEB Journal, 2020
The LPBN (lateral parabrachial nucleus) plays an important role in feeding control. CGRP (calcitonin gene‐related peptide) LPBN neurons activation mediates the anorectic effects of different gut‐derived peptides, including amylin.
Lavinia Boccia, C. Le Foll, T. Lutz
semanticscholar   +1 more source

iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT There are a number of guidelines on how to manage obesity, but inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices restrict their global applicability. This underscores the need for universal recommendations that address the unique challenges faced by patients and healthcare providers ...
Stefan D. Anker, Linong Ji, Tammy Kindel, Andrew J. S. Coats, Dike Ojji, Adriana Puente Barragán, Peter Rossing, Shelley Zieroth, Shaaf Ahmad, Shariq Usman, Geeta Appannah, Alison L. Bailey, Ahmed Bennis, Andrea Brandao, Javed Butler, Melanie J. Davies, Lubomira Fabryova, Yuan‐Lin Guo, Hidetaka Itoh, Uday M. Jadhav, Carel W. Le Roux, Fausto J. Pinto, Julio Rosenstock, Banshi Saboo, Hani Sabbour, Mangesh Tiwaskar, Karol E. Watson, Kwang Wei Tham, Fernando Stuardo Wyss, Walter P. Abhayaratna, William T. Abraham, Wael Al Mahmeed, Alessia Argirò, John J. Atherton, Danielle Belardo, Raquel Campuzano, Nandini Chatterjee, Marc‐André Cornier, Sarah Davies, Clemencia de Rueda Panadero, Anastase Dzudie, Ty J. Gluckman, Muhammad Shahzeb Khan, Kamlesh Khunti, Yuri Lopatin, Zhiyi Ma, Okechukwu S. Ogah, Abraham Oomman, Emilio S. Peralta Lopez, Ping Li, Paul Poirier, Julie Redfern, Giuseppe M. C. Rosano, Donna Ryan, Amit Saraf, Sameh Shaheen, Subodh Verma, Stephan von Haehling, Martha Gulati, Naveed Sattar, Jose Luis Zamorano   +60 more
wiley   +1 more source

Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats

Neuroscience Research
The pancreatic peptide amylin promotes negative energy balance in part through activation of amylin receptors (AmyRs) expressed in the ventral tegmental area (VTA), but studies have been limited to male rodents.
Tyler J. Gustafson, Lauren E. McGrath, Matthew R. Hayes, Elizabeth G. Mietlicki-Baase   +3 more
doaj   +1 more source