Results 61 to 70 of about 4,821 (183)

Does Incretin Agonism Have Sustainable Efficacy?

Cells
Recent clinical trials using synthetic incretin hormones, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists have demonstrated that these treatments ameliorated many complications related to obesity,
Sok-Ja Janket, Miyo K. Chatanaka, Dorsa Sohaei, Faleh Tamimi, Jukka H. Meurman, Eleftherios P. Diamandis   +5 more
doaj   +1 more source

Design of the liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (LEADER) trial. [PDF]

, 2013
BACKGROUND: Diabetes is a multisystem disorder associated with a nearly twofold excess risk for a broad range of adverse cardiovascular outcomes including coronary heart disease, stroke, and cardiovascular death.
Bergenstal, Richard M, Buse, John B, Daniels, Gilbert H, Frandsen, Kirstine Brown, Mann, Johannes FE, Marso, Steven P, Moses, Alan C, Nauck, Michael A, Nissen, Steven E, Pocock, Stuart, Poulter, Neil R, Ravn, Lasse Steen, Steinberg, William M, Zinman, Bernard   +13 more
core   +2 more sources

Effect of exenatide on splanchnic and peripheral glucose metabolism in type 2 diabetic subjects [PDF]

, 2011
OBJECTIVE: Our objective was to examine the mechanisms via which exenatide attenuates postprandial hyperglycemia in type 2 diabetes mellitus (T2DM). STUDY DESIGN: Seventeen T2DM patients (44 yr; seven females, 10 males; body mass index = 33.6 kg/m(2 ...
Cersosimo, Eugenio, Cervera, Antonio, Defronzo, Ralph A., Fernandez, Marianella, Gastaldelli, Amalia, Musi, Nicholas, Petz, Roberta, Sriwijilkamol, Apiradee, Triplitt, Curtis, Wajcberg, Estela, Zuo, Pengou   +10 more
core   +1 more source

Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). [PDF]

, 2012
Glycemic management in type 2 diabetes mellitus has become increasingly complex and, to some extent, controversial, with a widening array of pharmacological agents now available (1–5), mounting concerns about their potential adverse effects and new ...
Bergenstal, Richard M, Buse, John B, Diamant, Michaela, Ferrannini, Ele, Inzucchi, Silvio E, Matthews, David R., Nauck, Michael, Peters, Anne L, Tsapas, Apostolos, Wender, Richard   +9 more
core   +3 more sources

Glucagon-like peptide analogues for type 2 diabetes mellitus : systematic review and meta-analysis [PDF]

, 2010
Background Glucagon-like peptide (GLP-1) analogues are a new class of drugs used in the treatment of type 2 diabetes. They are given by injection, and regulate glucose levels by stimulating glucose-dependent insulin secretion and biosynthesis ...
Clar, C., Royle, Pamela, Sharma, Pawana, Shyangdan, D. (Deepson), Waugh, Norman   +4 more
core   +5 more sources

Once-Monthly and Extended-Interval Incretin-, Amylin-, and THRβ-Targeting Therapies for Type 2 Diabetes and Obesity: Clinical Evidence and Development Pipelines

Scientia Pharmaceutica
Once-monthly injectable therapies targeting glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and adjacent metabolic pathways are moving from a conceptual goal to a plausible next step for type 2 diabetes (T2D) and ...
Héctor Iván Saldívar-Cerón
doaj   +1 more source

GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence. [PDF]

, 2014
The parabrachial nucleus (PBN) is a key nucleus for the regulation of feeding behavior. Inhibitory inputs from the hypothalamus to the PBN play a crucial role in the normal maintenance of feeding behavior, because their loss leads to starvation ...
Anderberg, RH., Anesten, F., Dickson, SL., Farkas, Imre, Liposits, Zsolt, Richard, JE.   +5 more
core   +1 more source

The receptive function of hypothalamic and brainstem centres to hormonal and nutrient signals affecting energy balance [PDF]

, 2017
The hypothalamic arcuate nucleus (ARC) and the area postrema (AP) represent targets for hormonal and metabolic signals involved in energy homoeostasis, e.g.
Riediger, Thomas
core  

Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery? [PDF]

, 2013
The number of bariatric surgical procedures performed has increased dramatically. This review discusses the clinical and physiological changes, and in particular, the mechanisms behind weight loss and glycaemic improvements, observed following the ...
le Roux, CW, Miras, AD
core   +1 more source

Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model [PDF]

Arthritis Research & Therapy, 2019
Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction when administered alone.
Katri, Anna, Dąbrowska, Aneta, Löfvall, Henrik, Ding, Ming, Karsdal, Morten A., Andreassen, Kim V., Thudium, Christian S., Henriksen, Kim   +7 more
openaire   +6 more sources