Results 81 to 90 of about 1,279,543 (154)

Peroxisome Proliferator-Activated Receptor Agonists and Bladder Cancer: Lessons from Animal Studies

, 2014
This article reviews available animal studies on the possible link between the use of peroxisome proliferator-activated receptor (PPAR) agonists and bladder cancer, with further discussion on the possible implications to humans.
Tseng, Chin-Hsiao;Tseng, Farn-Hsuan, 曾慶孝   +1 more
core   +1 more source

The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection – a novel disease-modifying osteoarthritis drug

Arthritis Research & Therapy
Background Despite the extensive research to provide a disease-modifying osteoarthritis drug (DMOAD), there is still no approved DMOAD. Dual amylin and calcitonin receptor agonists (DACRA) can provide metabolic benefits along with antinociceptive and ...
Khaled Elhady Mohamed, Anna Thorsø Larsen, Simone Melander, Frederik Andersen, Ellen Barendorff Kerrn, Morten Asser Karsdal, Kim Henriksen   +6 more
doaj   +1 more source

Effect of antidiabetic drugs in Alzheimer´s disease: a systematic review of preclinical and clinical studies

Molecular Neurodegeneration
The potential neuroprotective effects of antidiabetic treatments have been largely assessed in Alzheimer’s disease (AD) and AD-like dementia models, with or without metabolic disorders.
Miriam Corraliza-Gomez, Maria Vargas-Soria, Monica Garcia-Alloza   +2 more
doaj   +1 more source

Comparative Efficacy and Safety of Semaglutide, Cagrilintide, and CagriSema in Adults with Overweight or Obesity: A Bayesian Network Meta-Analysis

Journal of Clinical Question
Introduction: Incretin-based therapies, including glucagon-like peptide-1 receptor agonists and amylin analogues, have emerged as promising treatments for obesity.
Yange Meng, Ting Jin, Luping Ren, Michelle L. Thompson, Yue Wang   +4 more
doaj   +1 more source

Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis.

PLoS ONE
The nuclear farnesoid X receptor (FXR), a master regulator of bile acid and metabolic homeostasis, is a key target for treatment of nonalcoholic steatohepatitis (NASH).
Luciano Adorini, Kristoffer Rigbolt, Michael Feigh, Jonathan Roth, Mary Erickson   +4 more
doaj   +1 more source

Synthesis of fatty acid mimetics and their characterization as PPARalpha/gamma agonists and dual mPGES-1/5-LO inhibitors [PDF]

, 2009
Die vorliegende, in kumulativer Schreibweise verfasste Arbeit erläutert die Entwicklung, Charakterisierung und Optimierung zweier unter­schiedlicher Leit­strukturen, die als Agonisten von Peroxisomen Proliferator-aktivierten Rezeptoren (PPAR) und ...
Zettl, Heiko
core  

Pharmacotherapy for Obesity: Recent Updates

Clinical Pharmacology: Advances and Applications
Thomas Ward Fredrick, Michael Camilleri, Andres Acosta Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USACorrespondence: Michael Camilleri, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905 ...
Fredrick TW, Camilleri M, Acosta A
doaj  

Papel do receptor ativado por proteinases-2 (par-2) no comportamento de coçar em camundongos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2009.O objetivo do presente estudo foi investigar os possíveis mecanismos e mediadores envolvidos no
Costa, Robson da
core  

Molecular Dynamics of Amylin Amyloid Single Beta-Sheet

Amyloidosis are metabolic conformational diseases caused by misfolding and aggregation of soluble proteins in insoluble fibrils which deposit squeezing out the functioning cells or block cell-to-cell connectivity.
Lapidus, Dmitrijs, Liepina, Inta, Czaplewsky, Cezary, Ventura, Salvador, Liwo, Adam   +4 more
core  

Management of diabetes across the course of disease: minimizing obesity-associated complications

Diabetes, Metabolic Syndrome and Obesity, 2011
Caroline M ApovianMedicine and Pediatrics, Boston University School of Medicine; Nutrition and Weight Management Center; and Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Obesity
Apovian CM
doaj