Results 1 to 10 of about 466,481 (267)

Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future [PDF]

Signal Transduction and Targeted Therapy, 2023
Weihong Song
exaly   +2 more sources

Wild Type Transthyretin Amyloid Cardiomyopathy Hidden Under Ablation-Refractory Atrial Arrhythmias and the Potential Contribution of Tafamidis in Rhythm Control. [PDF]

J Arrhythm
Horie T, Nagata Y, Nozato T, Miyazaki S, Ashikaga T.   +4 more
europepmc   +3 more sources

Interaction of Proteins Involved in Neuronal Proteinopathies

Life, 2023
Proteinopathy is characterized by the accumulation of aggregates of a specific protein in a target organ, tissue, or cell. The aggregation of the same protein can cause different pathologies as single protein can adopt various amyloidogenic, disease ...
Konstantin Y. Kulichikhin, Oksana A. Malikova, Anastasia E. Zobnina, Natalia M. Zalutskaya, Aleksandr A. Rubel   +4 more
doaj   +1 more source

Functional Mammalian Amyloids and Amyloid-Like Proteins

Life, 2020
Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s disease (PD ...
Maria S. Rubel, Sergey A. Fedotov, Anastasia V. Grizel, Julia V. Sopova, Oksana A. Malikova, Yury O. Chernoff, Aleksandr A. Rubel   +6 more
doaj   +1 more source

Evaluation of a new ELISA assay for monoclonal free‐light chain detection in patients with cardiac amyloidosis

eJHaem, 2022
The causal protein of amyloid light‐chain (AL) amyloidosis is a monoclonal immunoglobulin free light chain (mFLC), which must be quantified in the serum for patient diagnosis and monitoring.
Hajer Abroud, Asma Beldi‐Ferchiou, Vincent Audard, François Lemonnier, Fabien Le Bras, Karim Belhadj, Anissa Moktefi, Elsa Poullot, Khalil El Karoui, Jehan Dupuis, Alizée Maarek, Louise Roulin, Marie‐Hélène Delfau‐Larue, Silvia Oghina, Mounira Kharoubi, Mélanie Bézard, Amira Zaroui, Thibaud Damy, Valérie Molinier‐Frenkel   +18 more
doaj   +1 more source

An Efficient Method for Isolation of Plasmid DNA for Transfection of Mammalian Cell Cultures

Methods and Protocols, 2020
In this article, we present several protocols that describe the steps from cloning and obtaining a large amount of pure plasmid DNA to generation of lentiviruses based on these constructs.
Daniel V. Kachkin, Julia I. Khorolskaya, Julia S. Ivanova, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Implementing a Machine-Learning-Adapted Algorithm to Identify Possible Transthyretin Amyloid Cardiomyopathy at an Academic Medical Center

Clinical Medicine Insights: Cardiology, 2022
Background: Wild-type transthyretin amyloid cardiomyopathy (ATTR-CM) is a frequently under-recognized cause of heart failure (HF) in older patients. To improve identification of patients at risk for the disease, we initiated a pilot program in which 9 ...
Joshua D Mitchell, Daniel J Lenihan, Casey Reed, Ahsan Huda, Kim Nolen, Marianna Bruno, Thomas Kannampallil   +6 more
doaj   +1 more source

Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential [PDF]

Arquivos de Neuro-Psiquiatria, 2020
Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible loss of cognitive function. The presence of senile plaques is one of the pathological markers of the disease and is associated with the ...
Júlia Canto e SOUSA, Ana Carolina Fauaze SANTANA, Gabriela Jesus Prado MAGALHÃES   +2 more
doaj   +1 more source

Prevalence and determinants of iron deficiency in cardiac amyloidosis

ESC Heart Failure, 2022
Aims Iron deficiency (ID) is common in patient with chronic heart failure (HF) and has been widely studied. In contrast, data concerning ID in cardiac amyloidosis (CA) are limited.
Antoine Jobbé‐Duval, Mélanie Bézard, Stéphane Moutereau, Mounira Kharoubi, Silvia Oghina, Amira Zaroui, Arnault Galat, Coraline Chalard, Elisabeth Hugon‐Vallet, Francois Lemonnier, Damien Eyharts, Elsa Poulot, Pascale Fanen, Benoit Funalot, Valérie Molinier‐Frenkel, Vincent Audard, Luc Hittinger, Marc Antoine Delbarre, Emmanuel Teiger, Thibaud Damy   +19 more
doaj   +1 more source

Daratumumab binds to mobilized CD34+ cells of myeloma patients in vitro without cytotoxicity or impaired progenitor cell growth

Experimental Hematology & Oncology, 2018
Background The monoclonal antibody daratumumab, approved for treating myeloma, targets CD38, a protein on myeloma and also on CD34+ hematopoietic progenitor cells.
Xun Ma, Sandy W. Wong, Ping Zhou, Chakra P. Chaulagain, Parul Doshi, Andreas K. Klein, Kellie Sprague, Adin Kugelmass, Denis Toskic, Melissa Warner, Kenneth B. Miller, Lisa Lee, Cindy Varga, Raymond L. Comenzo   +13 more
doaj   +1 more source