What drives amyloid molecules to assemble into oligomers and fibrils? [PDF]
, 2010 We develop a general theory for three states of equilibrium of amyloid peptides: the monomer, oligomer, and fibril. We assume that the oligomeric state is a disordered micelle-like collection of a few peptide chains held together loosely by hydrophobic interactions into a spherical hydrophobic core.
Ahmad +54 more
arxiv +5 more sources
Functional Mammalian Amyloids and Amyloid-Like Proteins [PDF]
Life, 2020 Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s disease (PD ...
Maria S. Rubel +6 more
doaj +3 more sources
General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]
, 2014 Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Raleigh, David, Wang, Hui
core +14 more sources
Interaction of Proteins Involved in Neuronal Proteinopathies
Life, 2023 Proteinopathy is characterized by the accumulation of aggregates of a specific protein in a target organ, tissue, or cell. The aggregation of the same protein can cause different pathologies as single protein can adopt various amyloidogenic, disease ...
Konstantin Y. Kulichikhin +4 more
doaj +1 more source
eJHaem, 2022 The causal protein of amyloid light‐chain (AL) amyloidosis is a monoclonal immunoglobulin free light chain (mFLC), which must be quantified in the serum for patient diagnosis and monitoring.
Hajer Abroud +18 more
doaj +1 more source
Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study. [PDF]
, 2019 BACKGROUND:Current methods of amyloid PET interpretation based on the binary classification of global amyloid signal fail to identify early phases of amyloid deposition.
Alzheimer Precision Medicine Initiative (APMI) +14 more
core +3 more sources
The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design. [PDF]
, 2019 The development of inhibitors of islet amyloid formation is important as pancreatic amyloid deposition contributes to type-2 diabetes and islet transplant failure.
Akter, Rehana +4 more
core +3 more sources
Experimental Hematology & Oncology, 2018 Background The monoclonal antibody daratumumab, approved for treating myeloma, targets CD38, a protein on myeloma and also on CD34+ hematopoietic progenitor cells.
Xun Ma +13 more
doaj +1 more source
Prevalence and determinants of iron deficiency in cardiac amyloidosis
ESC Heart Failure, 2022 Aims Iron deficiency (ID) is common in patient with chronic heart failure (HF) and has been widely studied. In contrast, data concerning ID in cardiac amyloidosis (CA) are limited.
Antoine Jobbé‐Duval +19 more
doaj +1 more source
An Efficient Method for Isolation of Plasmid DNA for Transfection of Mammalian Cell Cultures
Methods and Protocols, 2020 In this article, we present several protocols that describe the steps from cloning and obtaining a large amount of pure plasmid DNA to generation of lentiviruses based on these constructs.
Daniel V. Kachkin +3 more
doaj +1 more source