Results 131 to 140 of about 11,332,305 (264)

Image_1_Risk factors in developing amyloid related imaging abnormalities (ARIA) and clinical implications.TIF

Alzheimer’s disease (AD) affects over 6 million people over the age of 65. The advent of new anti-amyloid monoclonal antibodies as treatment for early Alzheimer’s disease these immunotherapeutics may slow disease progression but also pose significant ...
Sarah J. Doran (17812700), Russell P. Sawyer (17812703)   +1 more
core   +1 more source

Development of a prognostic scoring system for systemic inflammatory response syndrome in donkeys

Equine Veterinary Journal, EarlyView.
Abstract Background Systemic inflammatory response syndrome (SIRS) is associated with increased mortality in horses with gastrointestinal (GI) disease. However, there are no data relating to naturally occurring SIRS in donkeys. Objectives To determine SIRS frequency in donkeys with GI disease. To develop a donkey‐specific prognostic SIRS score.
Marine A. Barnabé, Nicholas J. Bamford, Jonathan Elliott, Yu‐Mei Chang, Karen Rickards, Nicola J. Menzies‐Gow   +5 more
wiley   +1 more source

Diagnosis of bacteraemia in neonatal foals using 16S rRNA high‐throughput sequencing

Equine Veterinary Journal, EarlyView.
Abstract Background Sepsis is an important cause of morbidity and mortality in foals. Early diagnosis can improve outcome but is complicated by non‐specific clinical signs and delayed confirmation of infection via blood culture. Molecular assays represent a rapid and more sensitive alternative.
Flavie Payette, Alicia E. Long, Weiming Hu, Kyle Bittinger, Ahmed M. Moustafa, Darko Stefanovski, Michelle Abraham, Maia R. Aitken   +7 more
wiley   +1 more source

Symptomatic lobar intracerebral hemorrhage during extended lecanemab treatment: A case report

Journal of Alzheimer's Disease Reports
Lecanemab is an anti-amyloid-β protofibril antibody that slows cognitive decline in early Alzheimer's disease. Although amyloid-related imaging abnormalities (ARIA) occur predominantly early in treatment, reports of hemorrhagic events during extended ...
Yugo Takahashi, Naoyuki Shiraishi, Akihiro Tsukahara, Yukari Matsuda, Takuya Nishina, Hiroo Yoshikawa, Takashi Uzu, Etsuro Mori   +7 more
doaj   +1 more source

A fibril-selective single-domain antibody targets pathogenic amyloid-β assemblies and protects human neurons

iScience
Summary: Alzheimer disease is characterized by extracellular amyloid-β deposition that contributes to neuronal dysfunction and degeneration. Although anti-amyloid-β antibodies reduce plaque burden, their use requires monitoring for amyloid-related ...
Matt A. Greenlee, Soukaina Amniouel, Isabel Rivera, Jessica Suh, Natalia J. Martinez, Anton Simeonov, Elizabeth Head, Robert Tycko, Wei Zheng, Bryan D. Fleming, Qi Zhang   +10 more
doaj   +1 more source

Analgesic use, safety and pharmacokinetics of acetaminophen in equids: A structured scoping review

Equine Veterinary Journal, EarlyView.
Abstract Background Despite its frequent use in equine clinical practice, scientific data on the use of acetaminophen in horses remain limited. Objective To map and critically appraise the available evidence on the analgesic use, safety and pharmacokinetics of acetaminophen in horses. Study Design Structured scoping review.
Francisco Medina‐Bautista, Juan Manuel Serrano‐Rodríguez, María del Mar Granados   +2 more
wiley   +1 more source

A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration-Like Lesions at the Peripheral Retina. [PDF]

, 2015
Our understanding of the relevance of peripheral retinal abnormalities to disease in general and in age-related macular degeneration (AMD) in particular is limited by the lack of detailed peripheral imaging studies.
Florea, D, Lengyel, I, Peto, T, Leung, I, Bird, AC, Csutak, A, Jonasson, F   +6 more
core  

Emergency Care for Patients on Amyloid-Targeting Therapies in Alzheimer\u27s Disease [PDF]

The introduction of novel amyloid-targeting therapies for Alzheimer’s disease presents challenges for emergency clinicians. Patients on these therapies may present with amyloid related imaging abnormalities (ARIA) that are only detectable on magnetic ...
Chiang, Gloria, Sutherland, Jennifer, Melady, Don, Hagerman, Thomas K, Suh, Michelle, Biese, Kevin, Devi, Gayatri, Kennedy, Maura   +7 more
core   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Early binding of anti-amyloid antibodies to CAA drives complement activation, inflammation and ARIA in mice

Molecular Neurodegeneration
Anti-amyloid antibody treatment for Alzheimer’s disease is linked to Amyloid-Related Imaging Abnormalities (ARIA), including vasogenic edema (ARIA-E) and microhemorrhages (ARIA-H), especially in ApoE ε4/4 carriers.
Praveen Bathini, Stephan Schilling, Jens-Ulrich Rahfeld, David M. Holtzman, Takaomi C. Saido, Cynthia A. Lemere   +5 more
doaj   +1 more source