Results 151 to 160 of about 11,332,305 (264)

Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist

Journal of the Korean Society of Radiology
Lecanemab and donanemab have received full U.S. Food and Drug Administration (FDA) approval, and subsequently, lecanemab has been approved by the Korean FDA and it has recently entered commercial use in Korea.
So Yeong Jeong, Chong Hyun Suh, Jae-Sung Lim, Yangsean Choi, Ho Sung Kim, Sang Joon Kim, Jae-Hong Lee   +6 more
doaj   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Apathy in Lewy Body Disorders: A Position Paper

Movement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky, Lidia Bojtos, Milica G. Kramberger, Elisa Mantovani, Iulia Murasan, Jose‐Alberto Palma, Karolina Poplawska‐Domaszewicz, Anna Sauerbier, Kallol Ray Chaudhuri, Per Odin, Daniel Weintraub, Anette Schrag, Cristian Falup‐Pecorariu   +12 more
wiley   +1 more source

Neurofilament Light Chain and Mutant Huntingtin Across Huntington's Disease Integrated Staging System Stages in Huntington Disease: A Cross‐Sectional Multimodal Analysis

Movement Disorders, EarlyView.
Abstract Background The Huntington's Disease Integrated Staging System (HD‐ISS) provides a framework for staging HD but does not incorporate fluid biomarkers. Objective The aim of this study was to examine neurofilament light chain (NfL) and mutant huntingtin (mHTT) and total tau across HD‐ISS stages and their associations with genetic burden ...
Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Arnau Puig Davi, Rocío Pérez González, Jordi Pegueroles, Andrea Horta‐Barba, Anna Vázquez Oliver, Elisa Rivas Asensio, Daniel Alcolea, Juan Fortea, Marina Guasch‐Jiménez, Tomas Xuclà Ferrarons, Frederic Sampedro Santaló, Lidia Bojtos, Óscar López‐Lombardía, Ignacio Aracil‐Bolaños, Berta Pascual‐Sedano, Carla Franch Martí, Laura Pérez Carasol, Margarita Rubio Romera, Yi Ji, Alexandre Gironell, Antonia Campolongo, Raul Martínez‐Fernández, Alberto Lleó, Javier Pagonabarraga, Saul Martínez‐Horta, Jaime Kulisevsky, BCN‐HD Working Group;, HDClarity investigators, Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Saül Martínez‐Horta, Arnau Puig‐Davi, Carla Franch, Paula Arranz‐Horno, Oscar López‐Lombardía, Lidia Bojtos, Antonia Campolongo, Javier Pagonabarraga, Jaime Kulisevsky, Asunción Ávila, Nuria Caballol, Alejandro Peral, Jesús Ruíz‐Idiago, Misericordia Floriach, Matilde Calopa, Helena Bejr Kasem, Clara Marzal Espí, Esteban Muñoz, Celia Painous, Irene Navalpotro, Victor Puente, Victoria González, Pau Pastor, Dolores Vilas, Iñigo Ruiz Barrio, Lourdes Ispierto, Eliot Gómez‐López, Claustre Pons, Gracia Pons, Maria Teresa Buongiorno, Anna Mas, Maria Pilar Gil, Jordi Casanovas, Edward Wild, Tiago Mestre, Mark Guttman, Philippe Rizek, Blair Leavitt, Carsten Saft, Bjorn Falkenburger, Juergen Winkler, Ralf Reilmann, Jan Lewerenz, Alzbeta Mühlbäck, Jesús Pérez‐Pérez, Tamara Fernandez Valle, José Luis López‐Sendón Moreno, Christophe Verny, Cyril Goizet, Caterina Mariotti, Ferdinando Squitieri, Tim Anderson, Richard Roxburgh, Grzegorz Witkowski, Leonor Correia Guedes, Hugh Rickards, Elizabeth Coulthard, Roger Barker, Anne Rosser, Tim Harrower, Robert Thompson, James Herron, Jeremy Cosgrove, Rhys Davies, Nayana Lahiri, Richard Armstrong, Daniel Lashley, Jee Bang, Erin Furr‐Stimming, Jessica Tate, Meagen Salinas, Karen Anderson, Amy Brown   +104 more
wiley   +1 more source

The Gut–Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism‐Based Precision Medicine

Movement Disorders, EarlyView.
Abstract Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non‐motor symptoms to a central component of ...
Filip Scheperjans, Per Borghammer, Ronald F. Pfeiffer, Silke Appel‐Cresswell, Ali Keshavarzian   +4 more
wiley   +1 more source

Automated Magnetic Resonance Volumetry to Measure Multiple System Atrophy Disease Progression in Clinical Trials

Movement Disorders, EarlyView.
Abstract Background Recent studies have reported longitudinal brain atrophy in multiple system atrophy (MSA) in relatively small patient cohorts. Objective To compare longitudinal regional brain volume and clinical changes as endpoint measures for MSA clinical trials.
Andrea Quattrone, Ida Wilkens, Zeyu Zhu, Irfan A. Qureshi, Nicolai Franzmeier, Günter U. Höglinger, for the M‐STAR Study Group, Phillip Low, Wolfgang Singer, Stuart Isaacson, Susan Perlman, Tao Xie, Zbigniew Wszolek, Diana Kerwin, Diana Apateurova, Theresa Zesiewicz, Roy Freeman, Rajesh Pahwa, Nikolaus McFarland, Eric Molho, Michael Geschwind, Rajeev Kumar, Sana Aslam, Dignity Health, Jee Bang, Aaron Ellenbogen, Italo Biaggioni, Andres Deik, Patricio Millar Vernetti, Jose‐Alberto Palma‐Carazo, Horacio Kaufmann, Pravin Khemani, Jeremy Schmahmann, Xuemei Huang, Irene Litvan, Mitchell Miglis, Deborah Hall, Sheng‐Han Kuo, Stewart Factor, Steven Vernino, Werner Poewe, Caroline Thun‐Hohenstein, Sophie Drapier, Alexandre Eusebio, Wassilios Meissner, Anne Pavy Le Traon, Christine Tranchant, Daniela Berg, Jost‐Julian Rumpf, Karla Eggert, Alfons Schnitzler, Lars Tönges, Jens Ebentheuer, Claudia Trenkwalder, Inga Claus, Tobias Warnecke, Guenter Hoeglinger, Annika Spottke, Nicola Pavese, Alessio DiFonzo, Paolo Barone, Huw Morris, Klaus Seppi   +62 more
wiley   +1 more source

Therapeutic Impact of GLP‐1 Receptor Agonists on Parkinson's Disease: A Scoping Review

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT No disease‐modifying treatment exists for Parkinson's disease (PD). Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have gained attention as promising candidates for neuroprotection, given documented expression of GLP‐1 receptors within the central nervous system and the contribution of brain insulin resistance to dopaminergic ...
João Pedro Henriques, João Pedro Stringhetta Rahal, Rafael da Cunha Gomes Ribeiro, Enzo Bogucheski Ribeiro Machado, Carlos Antonio Negrato   +4 more
wiley   +1 more source

Serum elemental profile‐based machine learning models for Alzheimer's disease identification and cognitive score prediction

Neuroprotection, EarlyView.
Serum elemental profiling combined with machine learning supports exploratory Alzheimer's disease (AD) identification and cognitive score prediction. In this retrospective cross‐sectional study, 874 participants from the BANC‐PUMC, including cognitively normal controls and patients with AD, were analyzed.
Haotian Liu, Xinnan Liu, Yashuang Chen, Meng Pan, Ying Fu, Chao Ma, Wei Ge   +6 more
wiley   +1 more source

Volume change with gantenerumab: Impact of amyloid-related imaging abnormalities and amyloid removal. [PDF]

Alzheimers Dement
Tonietto M, Silvestri E, Belder CRS, Barkhof F, Fox NC, Smith J, Klein G.   +6 more
europepmc   +1 more source

Muscle fatigue in patients with severe long COVID: A 2‐year follow‐up study

PM&R, EarlyView.
Abstract Background Fatigue is recognized as one of the most persistent and debilitating symptoms of long COVID, affecting both functionality and quality of life. However, its long‐term effects, especially beyond the first year after infection, remain poorly understood.
Isabella da Silva Almeida, Leandro Gomes de Jesus Ferreira, Marco Aurélio Vaz, Rochelle Rocha Costa, Nicolas Babault, Rita de Cássia Marqueti, João Luiz Quagliotti Durigan   +6 more
wiley   +1 more source