Results 111 to 120 of about 516,976 (376)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra +17 more
wiley +1 more source
Pharmacotherapy of Alzheimer’s Disease: Seeking Clarity in a Time of Uncertainty
Frontiers in Pharmacology, 2020 Alzheimer’s disease (AD) is recognized as a major health hazard that mostly affects people older than 60 years. AD is one of the biggest medical, economic, and social concerns to patients and their caregivers.
Nurul Husna Ibrahim +7 more
doaj +1 more source
Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]
, 2013 Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S +6 more
core +1 more source
Diagnostic Challenge in Frontal Variant Alzheimer's Disease With Low Amyloid‐β PET Retention
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Diagnosing frontal variant Alzheimer's disease (fvAD) is difficult and could be even more difficult when amyloid‐beta (Aβ) PET retention is low. A 63‐year‐old woman presenting with a 3‐year history of apathy and memory impairment showed executive dysfunction, memory impairment, and severe bilateral frontotemporal atrophy on MRI.
Ryosuke Shimasaki +5 more
wiley +1 more source
A designed protein interface that blocks fibril formation [PDF]
, 2004 Protein fibril formation is implicated in many diseases, and therefore much effort has been focused toward the development of inhibitors of this process.
Huang, Po-Ssu +4 more
core +1 more source
Amyloid and inflammation [PDF]
Proceedings of the National Academy of Sciences, 2013 Thirty human and 10 animal proteins form amyloid fibrils associated with codeposition of P-component (SAP), heparatan sulfate proteoglycans (HSPGs), certain apolipoproteins (e.g., ApoE), as well as other less well-defined “ground substances” that may mitigate fibrillogenesis and tissue-specific deposition in association with aging or disease.
openaire +3 more sources
Frontiers in Chemistry, 2018 Inhibition of fibrillation process and disaggregation of mature fibrils using small peptide are the promising remedial strategies to combat neurodegenerative diseases. However, designing peptide-based drugs to target β-sheet-rich amyloid has been a major
Mohammad K. Siddiqi +11 more
doaj +1 more source
Molecules, 2020 The term “amyloid” refers to proteinaceous deposits of peptides that might be generated from larger precursor proteins e.g., by proteolysis.
Kristina Endres
doaj +1 more source
Cerebral Amyloid Angiopathy Is Associated With Higher R2 Relaxation Rate: An MRI and Pathology Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cerebral amyloid angiopathy (CAA) involves β‐amyloid deposition in the walls of cortical and leptomeningeal small vessels. Transverse relaxation rate (R2) is a major source of contrast in MRI. This study tested the hypothesis that CAA is associated with R2, extracted the spatial pattern of CAA‐related R2 abnormalities, and evaluated ...
Md Tahmid Yasar +6 more
wiley +1 more source
Coiled-Coil Motifs of RNA-Binding Proteins: Dynamicity in RNA Regulation
Frontiers in Cell and Developmental Biology, 2020 Neuronal granules are biomolecular condensates that concentrate high quantities of RNAs and RNA-related proteins within neurons. These dense packets of information are trafficked from the soma to distal sites rich in polysomes, where local protein ...
Lenzie K. Ford, Luana Fioriti
doaj +1 more source