Advanced Science, EarlyView.The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai +7 more
wiley +1 more source
Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose
Science and Technology of Advanced Materials, 2008 A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1–42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy.
Yoshiko Miura et al
doaj
SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA) [PDF]
, 2018 Laurent Pradier +24 more
openalex +1 more source
Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics
Advanced Science, EarlyView.The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu +4 more
wiley +1 more source
Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein [PDF]
, 2014 Ximing Li +3 more
openalex +1 more source
Innovative IgG Biomarkers Based on Phage Display Microbial Amyloid Mimotope for State and Stage Diagnosis in Alzheimer’s Disease [PDF]
, 2020 Laura Maria De Plano +11 more
openalex +1 more source
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
Brain Amyloid Plaque Levels Affect Clinical Progression in Alzheimer Disease: Assessment of Amyloid PET and Change in CDR-SB Utilizing Semi-Mechanistic Model. [PDF]
CPT Pharmacometrics Syst PharmacolBhagunde P +7 more
europepmc +1 more source
Advanced Science, EarlyView.Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan +6 more
wiley +1 more source