Results 121 to 130 of about 514,761 (295)

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons [PDF]

, 2016
Adam P. Gunn, Bruce X. Wong, Timothy Johanssen, James C. Griffith, Colin L. Masters, Ashley I. Bush, Kevin J. Barnham, James A. Duce, Robert A. Cherny   +8 more
openalex   +1 more source

Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease

, 2021
Izzeddin Alsalahat, Zubida M. Al‐Majdoub, Mutasem O. Taha, Jill Barber, Harmesh Aojula, Nigel W. Hodson, Sally Freeman   +6 more
openalex   +1 more source

Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE

Nature Neuroscience, 2018
Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with late-onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2.
S. Parhizkar, T. Arzberger, M. Brendel, G. Kleinberger, M. Deussing, C. Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, N. Katzmarski, S. Krasemann, S. Lichtenthaler, S. Müller, A. Colombo, L. S. Monasor, S. Tahirovic, J. Herms, M. Willem, Nadine Pettkus, O. Butovsky, P. Bartenstein, D. Edbauer, A. Rominger, Ali Ertürk, Stefan A. Grathwohl, J. Neher, D. Holtzman, Melanie Meyer-Luehmann, C. Haass   +28 more
semanticscholar   +1 more source

Microneedles From Shape‐Preserving Crosslinked Poly(Vinyl Alcohol) Hydrogels: Minimising Interference in Transdermal Proteomics

Advanced Materials Technologies, EarlyView.
Hydrogel‐forming microneedle patches are developed using shape‐preserving PVA‐PVP hydrogels, with and without chitosan, for minimally invasive transdermal protein biomarker sampling. The optimised patches enable efficient interstitial fluid uptake and proteomic analysis, while minimising interference.
Achmad Himawan, Robert Graham, Fabiana Volpe‐Zanutto, Huanhuan Li, Anjali K. Pandya, Andi Nur Aisyah, Rina Agustina, Juan L. Paris, Juan Dominguez‐Robles, Lalitkumar K. Vora, Andi D. Permana, Christopher J. Scott, Ryan F. Donnelly   +12 more
wiley   +1 more source

Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles

International Journal of Nanomedicine, 2010
Sun-Ho Han1, Yu Jin Chang1, Eun Sun Jung1, Jong-Won Kim2, Duk Lyul Na3, Inhee Mook-Jung11Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Jongro-gu, Seoul, Korea; 2Department of Laboratory Medicine and ...
Sun-Ho Han, Yu Jin Chang, Eun Sun Jung, et al   +3 more
doaj  

Serum amyloid A – a review

Molecular Medicine, 2018
Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are small (104 amino acids) and have a striking relationship to the acute phase response with serum levels rising as much as 1000-fold in 24 hours. SAA proteins are encoded in
G. Sack
semanticscholar   +1 more source

Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives

Advanced Photonics Research, EarlyView.
Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka, Lenka Vaňková, Josef Sýkora, Věra Křížková, Jan Schwarz, Petr Bouř   +5 more
wiley   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Green synthesis of nanoparticles using medicinal plants as an eco-friendly and therapeutic potential approach for neurodegenerative diseases: a comprehensive review

Frontiers in Neuroscience
Central nervous system disorders impact over 1.5 billion individuals globally, with neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases being particularly prominent.
Rezvan Izadi, Seifollah Bahramikia, Vali Akbari   +2 more
doaj   +1 more source