Results 171 to 180 of about 504,545 (312)

Depression and anxiety modify cognitive concerns associated with amyloid and early clinical impairment. [PDF]

Neuropsychology
Stites SD, Schumann R, Shi Y, Mechanic-Hamilton D, Wolk DA, Alzheimer’s Disease Neuroimaging Initiative.   +5 more
europepmc   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory

, 2008
Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley, Steven N. Johnson, Lin Xu, William Banks, Kelvin A. Yamada, Susan Farr   +5 more
core  

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants. [PDF]

Acta Neuropathol
Fancy NN, Willumsen N, Chau VMN, Boulger SL, Whitwell HJ, Wang W, Avot B, Thomas M, Talbot-Martin J, Tsartsalis S, Khozoie C, McGarry A, Schneegans E, Yagoubi R, Cheung TKD, Papageorgopoulou M, Adair E, Cooper B, Davey K, Smith AM, Scotton W, Hardy J, Matthews PM, Jackson JS.   +23 more
europepmc   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Amyloid Imaging [PDF]

Journal of Nuclear Medicine Technology, 2018
openaire   +2 more sources

Blood-based proteomic signature of amyloidosis: identification of novel regulators of amyloid load. [PDF]

Alzheimers Dement
Chen Y, Duggan MR, Timsina J, Xu Y, Western D, Gong K, Liu M, Budde J, Schindler SE, Morris JC, Holtzman DM, Benzinger TLS, Gordon BA, Moqri M, Knight Alzheimer Disease Research Center (Knight‐ADRC), Ibanez L, Walker KA, Cruchaga C, Ali M.   +18 more
europepmc   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

An ABC of Amyloid [PDF]

Proceedings of the Royal Society of Medicine, 1973
openaire   +2 more sources