Results 231 to 240 of about 466,481 (267)

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Characterizing Amyloid Pathogenic Spread in Alzheimer's Disease Through A Network Diffusion Model. [PDF]

ACM BCB
Xu FH, Duong-Tran D, Huang H, Saykin AJ, Thompson P, Davatzikos C, Zhao Y, Shen L.   +7 more
europepmc   +1 more source

Characterizing Alzheimer’s Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record–Based Data

Clinical Pharmacology &Therapeutics, EarlyView.
Hypertension is a known modifiable risk factor for Alzheimer’s disease and related dementia (ADRD). However, it is unknown how variance in hypertension control, antihypertensive medications, and social determinants of health, such as social deprivation index (SDI), influence the risk of developing ADRD.
Eissa A. Jafari, Mona Alshahawey, Muhammad A. Zaman, Steven M. Smith, Yan Gong, Glenn E. Smith, Caitrin W. McDonough   +6 more
wiley   +1 more source

Cryo-EM of Cardiac AL-224L Amyloid Reveals Shared Structural Motifs and Mutation-induced Differences in λ6 Light Chain Fibrils. [PDF]

J Mol Biol
Hicks CW, Prokaeva T, Spencer B, Jayaraman S, Huda N, Wong S, Chen H, Sanchorawala V, Lavatelli F, Gursky O.   +9 more
europepmc   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Spontaneous and Drug-Induced Amyloid-Related Imaging Abnormalities: Overlaps, Divergences, and Clinical Implications Across a Continuum Between Alzheimer's Disease and Cerebral Amyloid Angiopathy. [PDF]

Biomolecules
Zedde M, Losa M, Grisafi E, Lucia DD, Gandoglia I, Del Sette M, Pardini M, Roccatagliata L, Pascarella R, Piazza F.   +9 more
europepmc   +1 more source

Structural basis for T-cell intracellular antigen-1 amyloid fibril formation revealed by cryo-electron microscopy. [PDF]

PNAS Nexus
Inaoka D, Miyata T, Makino F, Ohtani Y, Ekari M, Kobayashi R, Imamura K, Sakamoto E, Kodama TS, Yoshida N, Kato T, Namba K, Tochio H, Sekiyama N.   +13 more
europepmc   +1 more source

Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease. [PDF]

Alzheimers Dement
Kennedy JT, Wisch JK, Boerwinkle AH, Millar PR, McKay NS, Brickman AM, Chhatwal JP, Mendez PC, Christian BT, Cohen A, Cruchaga C, Daniels A, Flores S, Handen BL, Hartley SL, Head E, Ibanez L, Krisnsky-McHale SJ, la Fougere C, Lai F, Laymon CM, Lee JH, Lee JH, Levin J, Llibre-Guerra J, Aguillon DF, Lott IT, Mapstone M, McDade E, Morris J, O'Bryant SE, Price JC, Rafii MS, Roh JH, Rosas HD, Schupf N, Supnet-Bell C, Xiong C, Zaman S, Benzinger TLS, Gordon BA, Ances BM, Alzheimer's Brain Consortium – Down Syndrome, and the Dominantly Inherited Alzheimer's Network.   +43 more
europepmc   +1 more source

Mapping Alzheimer's disease heterogeneity with molecular imaging biomarkers. [PDF]

Eur J Clin Invest
Harput E, Boccalini C, Mathoux G, Prior JO, Testart N, Jreige M, Garibotto V.   +6 more
europepmc   +1 more source