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Evolving Alzheimer's Disease Clinical Practice: Updated Diagnostic Criteria, Fluid Biomarkers, and Special Considerations for Anti-Amyloid Therapies. [PDF]
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ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
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Heart, Lung and Circulation, 2020
Amyloid cardiomyopathy is emerging as an important and under-recognised cause of heart failure and cardiac arrhythmias, especially in older adults. This disorder is characterised by extracellular deposition of amyloid fibrils that form due to misfolding of secreted light chains (AL) or transthyretin protein (ATTR). In ATTR, amyloid aggregates typically
Nicole K. Bart +5 more
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Amyloid cardiomyopathy is emerging as an important and under-recognised cause of heart failure and cardiac arrhythmias, especially in older adults. This disorder is characterised by extracellular deposition of amyloid fibrils that form due to misfolding of secreted light chains (AL) or transthyretin protein (ATTR). In ATTR, amyloid aggregates typically
Nicole K. Bart +5 more
openaire +5 more sources
Essays in Biochemistry, 2014
Amyloid fibrils are formed by numerous proteins and peptides that share little sequence homology. The structures formed are highly ordered and extremely stable, being composed of β-sheet structure and stabilized along their length by hydrogen bonding. The fibrils are formed by several protofilaments that wind around one another in rope-like structures,
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Amyloid fibrils are formed by numerous proteins and peptides that share little sequence homology. The structures formed are highly ordered and extremely stable, being composed of β-sheet structure and stabilized along their length by hydrogen bonding. The fibrils are formed by several protofilaments that wind around one another in rope-like structures,
openaire +2 more sources
Diseases of the Colon & Rectum, 1982
Amyloidosis not infrequently involves the gastrointestinal tract and may result in a variety of symptoms, including those related to impaired motility, malabsorption, and ulceration due to ischemia. This report describes the case of a 74-year-old man with systemic amyloidosis secondary to multiple myeloma, with striking gross morphologic findings ...
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Amyloidosis not infrequently involves the gastrointestinal tract and may result in a variety of symptoms, including those related to impaired motility, malabsorption, and ulceration due to ischemia. This report describes the case of a 74-year-old man with systemic amyloidosis secondary to multiple myeloma, with striking gross morphologic findings ...
openaire +2 more sources
Progress in Cardiovascular Diseases, 2010
Heart involvement can have devastating consequences. The clinical consequences will depend on the type of amyloid, the extent of systemic involvement and treatment options. Patients in whom disease recognition is late have poor outcomes, because of the severity of cardiac compromise and the necessarily aggressive treatments.
Rodney H, Falk, Simon W, Dubrey
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Heart involvement can have devastating consequences. The clinical consequences will depend on the type of amyloid, the extent of systemic involvement and treatment options. Patients in whom disease recognition is late have poor outcomes, because of the severity of cardiac compromise and the necessarily aggressive treatments.
Rodney H, Falk, Simon W, Dubrey
openaire +3 more sources