Results 21 to 30 of about 516,976 (376)
Search and Identification of Amyloid Proteins
Methods and Protocols, 2023 Amyloids are fibrillar proteins with a cross-β structure. Pathological amyloids are associated with the development of a number of incurable diseases, while functional amyloids regulate vital processes. The detection of unknown amyloids in living objects
Tatyana A. Belashova +5 more
doaj +1 more source
Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]
, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris +7 more
core +1 more source
BMC Nephrology, 2022 Background Multiple myeloma (MM) is a malignant neoplasm associated with kidney involvement in nearly half of the patients. Cast nephropathy, monoclonal immunoglobulin deposition disease (MIDD), and light chain (AL) amyloidosis are the most common ...
Samantha Innocenti +9 more
doaj +1 more source
Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]
, 2009 Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
core +2 more sources
Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis [PDF]
Frontiers in Cellular Neuroscience, 2020 Due to their postmitotic status, the potential for neurons to undergo senescence has historically received little attention. This lack of attention has extended to some non-postmitotic cells as well. Recently, the study of senescence within the central nervous system (CNS) has begun to emerge as a new etiological framework for neurodegenerative ...
Chaska C. Walton +3 more
openaire +3 more sources
Functional Amyloid Formation within Mammalian Tissue [PDF]
, 2005 Amyloid is a generally insoluble, fibrous cross-β sheet protein aggregate. The process of amyloidogenesis is associated with a variety of neurodegenerative diseases including Alzheimer, Parkinson, and Huntington disease.
Atanas V Koulov +50 more
core +4 more sources
The relationship between amyloid structure and cytotoxicity [PDF]
, 2014 Self-assembly of proteins and peptides into amyloid structures has been the subject of intense and focused research due to their association with neurodegenerative, age-related human diseases and transmissible prion diseases in humans and mammals. Of the
Marchante, Ricardo +3 more
core +1 more source
The amyloid precursor protein: beyond amyloid.
Molecular neurodegeneration, 2006 The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the beta-amyloid (Abeta) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD ...
Hui Zheng +3 more
openaire +4 more sources
Alzheimer’s Research & Therapy, 2022 Background Aggregated amyloid-β (Aβ) is considered a pathogenic initiator of Alzheimer’s disease (AD), in strong association with tau hyperphosphorylation, neuroinflammation, synaptic dysfunction, and cognitive decline.
Hee Yang Lee +17 more
doaj +1 more source
Haematologica, 2013 We report results of a phase II trial of combination of melphalan, lenalidomide, and dexamethasone for the treatment of immunoglobulin light chain (AL) amyloidosis.
Vaishali Sanchorawala +5 more
doaj +1 more source