Results 21 to 30 of about 514,761 (295)
Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage [PDF]
, 2004 BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates.
Freeman, Melissa J +6 more
core +3 more sources
Microglia use TAM receptors to detect and engulf amyloid beta plaques
Nature Immunology, 2021 Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally.
Youtong Huang +7 more
semanticscholar +1 more source
International Journal of Translational Medicine, 2023 Due to global population growth, age-related disorders like cardiovascular disease and dementia are anticipated to increase. Recent data suggests a connection between cardiovascular disease and neurodegeneration, especially focusing on arterial stiffness
Jhana O. Hendrickx +4 more
doaj +1 more source
A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils [PDF]
, 2008 Misfolding and aggregation of normally soluble proteins into amyloid fibrils and their deposition and accumulation underlies a variety of clinically significant diseases.
Jahn, T.R., Radford, S.E., Tennent, G.A.
core +2 more sources
Brain amyloid in preclinical Alzheimer\u27s disease is associated with increased driving risk [PDF]
, 2016 INTRODUCTION: Postmortem studies suggest that fibrillar brain amyloid places people at higher risk for hazardous driving in the preclinical stage of Alzheimer's disease (AD). METHODS: We administered driving questionnaires to 104 older drivers (19 AD, 24
Bernier, Justine N +7 more
core +2 more sources
Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
Haematologica, 2013 Amyloidosis of the gastrointestinal tract, with biopsy-proven disease, is rare. We reviewed a series of patients who presented with biopsy-proven gastrointestinal amyloidosis and report their clinical characteristics, treatments, and survival.
Andrew J. Cowan +7 more
doaj +1 more source
The Mutability of Yeast Prions
Viruses, 2022 Prions replicate by a self-templating mechanism. Infidelity in the process can lead to the emergence of new infectious structures, referred to as variants or strains.
Chih-Yen King
doaj +1 more source
Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
Neural Regeneration Research, 2022 Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau ...
Alejandro R Roda +4 more
semanticscholar +1 more source
Haematologica, 2013 We report results of a phase II trial of combination of melphalan, lenalidomide, and dexamethasone for the treatment of immunoglobulin light chain (AL) amyloidosis.
Vaishali Sanchorawala +5 more
doaj +1 more source
Biochemical Principles in Prion-Based Inheritance
Epigenomes, 2022 Prions are proteins that can stably fold into alternative structures that frequently alter their activities. They can self-template their alternate structures and are inherited across cell divisions and generations.
Emily M. Dennis, David M. Garcia
doaj +1 more source