Results 21 to 30 of about 466,481 (267)

Night‐to‐night variability in sleep and amyloid beta burden in normal aging

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants
Aurore Jouvencel, Marion Baillet, Marie Meyer, Bixente Dilharreguy, Frederic Lamare, Karine Pérès, Catherine Helmer, Jean‐François Dartigues, Hélène Amieva, Willy Mayo, Gwenaëlle Catheline   +10 more
doaj   +1 more source

Implication of tau propagation on neurodegeneration in Alzheimer’s disease

Frontiers in Neuroscience, 2023
Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen during the progression of Alzheimer’s disease (AD). Although it is not well-established what drives or attenuates tau spreading, new studies on human brain using
Daniel Lamontagne-Kam, Anosha Kiran Ulfat, Vincent Hervé, Tra-My Vu, Jonathan Brouillette   +4 more
doaj   +1 more source

The Development of an Early Diagnostic Method for Alzheimer’s Disease

Proceedings
Alzheimer’s disease (AD) is the most common form of dementia, characterized by neuronal degeneration and death [...]
Yulia K. Styufliaeva, Andrew A. Zelinsky, Oksana A. Malikova, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Yeast Approach in Amyloidogenic Proteins Study

Proceedings
Self-reproducing protein aggregates of a fibrillar nature (amyloids) are associated with a number of animal and human diseases [...]
Andrew A. Zelinsky, Marina V. Ryabinina, Yury O. Chernoff, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Analysis of the Amyloid-like Properties of COL2A1 Protein

Proceedings
Amyloids are proteins which exist in the form of insoluble aggregates and possess a characteristic cross-beta structure [...]
Aleksandra Brukkel, Andrew A. Zelinsky, Marina V. Ryabinina, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Curiosity-Based Interventions Increase Everyday Functioning Score But Not Serum BDNF Levels in a Cohort of Healthy Older Adults

Frontiers in Aging, 2021
An enriched environment is effective in stimulating learning and memory in animal models as well as in humans. Environmental enrichment increases brain-derived neurotrophic factor (BDNF) in aged rats and reduces levels of Alzheimer-related proteins in ...
Allison N. Grossberg, Brianne M. Bettcher, Kim A. Gorgens, Aurélie Ledreux   +3 more
doaj   +1 more source