Results 31 to 40 of about 516,976 (376)
Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. [PDF]
, 2015 In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are commonly viewed as a marker of cerebral small vessel disease (SVD).
Alzheimer’s Disease Neuroimaging Initiative +7 more
core +2 more sources
Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure [PDF]
The EMBO Journal, 2021 It is still unclear why pathological amyloid deposition initiates in specific brain regions or why some cells or tissues are more susceptible than others. Amyloid deposition is determined by the self-assembly of short protein segments called aggregation-prone regions (APRs) that favour cross-β structure.
Meine Ramakers +14 more
openaire +4 more sources
Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
Haematologica, 2013 Amyloidosis of the gastrointestinal tract, with biopsy-proven disease, is rare. We reviewed a series of patients who presented with biopsy-proven gastrointestinal amyloidosis and report their clinical characteristics, treatments, and survival.
Andrew J. Cowan +7 more
doaj +1 more source
Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice [PDF]
, 2007 The amino acid sequence of amyloid precursor protein (APP) is highly conserved, and age-related Abeta aggregates have been described in a variety of vertebrate animals, with the notable exception of mice and rats.
Borchelt, David R. +7 more
core +1 more source
Biomedical Papers, 2017 Amyloidosis is a heterogeneous group of diseases characterized by the deposition of amyloid. It is caused by extracellular deposition of insoluble fibrils with beta-pleated sheet configuration. The protein misfolding abnormalities result in amyloid fibrils and may manifest as primary, secondary, or familial amyloidosis.
Lucie Karafiatova, Tomas Pika
openaire +3 more sources
BMC Family Practice, 2020 Background Transthyretin amyloidosis (also known as ATTR amyloidosis) is a systemic, life-threatening disease characterized by transthyretin (TTR) fibril deposition in organs and tissue. A definitive diagnosis of ATTR amyloidosis is often a challenge, in
Morie Gertz +23 more
doaj +1 more source
Succinct Amyloid and Non-Amyloid Patterns in Hexapeptides [PDF]
arXiv, 2022 Hexapeptides are widely applied as a model system for studying amyloid-forming properties of polypeptides, including proteins. Recently, large experimental databases have become publicly available with amyloidogenic labels. Using these datasets for training and testing purposes, one may build artificial intelligence (AI)-based classifiers for ...
arxiv
Acceleration of amyloid fibril formation by multichannel sonochemical reactor [PDF]
, 2021 Formation of amyloid fibrils of various amyloidogenic proteins is dramatically enhanced by ultrasound irradiation. For applying this phenomenon to the study of protein aggregation science and diagnosis of neurodegenerative diseases, a multichannel ultrasound irradiation system with individually adjustable ultrasound-irradiation conditions is necessary.
arxiv +1 more source
A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils [PDF]
, 2008 Misfolding and aggregation of normally soluble proteins into amyloid fibrils and their deposition and accumulation underlies a variety of clinically significant diseases.
Jahn, T.R., Radford, S.E., Tennent, G.A.
core +2 more sources
Localized Amyloid Degeneration; Amyloid Lymphoma (?) [PDF]
The Boston Medical and Surgical Journal, 1886 n ...
openaire +3 more sources