Results 31 to 40 of about 514,761 (295)

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice [PDF]

, 2005
BACKGROUND: The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense
Dickey, Chad A, Freeman, Melissa J, Gordon, Marcia N, Herber, Donna L, Morgan, Dave, Wilcock, Donna M   +5 more
core   +3 more sources

Disease progression and costs at the 3‐year follow‐up of the GERAS‐US study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
Introduction GERAS‐US prospectively characterized clinical and economic outcomes of early symptomatic Alzheimer's disease (AD). Societal cost changes were examined in amyloid‐positive patients with mild cognitive impairment due to AD (MCI) and mild ...
Julie M. Chandler, Dorene M. Rentz, Anthony Zagar, Yongin Kim, Ronald L. Schwartz, Howard Fillit   +5 more
doaj   +1 more source

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]

, 2015
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S., Cameron, Ryan T., Hillert, Ellin-Kristina, MacLeod, Ruth   +3 more
core   +1 more source

Avoiding misdiagnosis: expert consensus recommendations for the suspicion and diagnosis of transthyretin amyloidosis for the general practitioner

BMC Family Practice, 2020
Background Transthyretin amyloidosis (also known as ATTR amyloidosis) is a systemic, life-threatening disease characterized by transthyretin (TTR) fibril deposition in organs and tissue. A definitive diagnosis of ATTR amyloidosis is often a challenge, in
Morie Gertz, David Adams, Yukio Ando, João Melo Beirão, Sabahat Bokhari, Teresa Coelho, Raymond L. Comenzo, Thibaud Damy, Sharmila Dorbala, Brian M. Drachman, Marianna Fontana, Julian D. Gillmore, Martha Grogan, Philip N. Hawkins, Isabelle Lousada, Arnt V. Kristen, Frederick L. Ruberg, Ole B. Suhr, Mathew S. Maurer, Jose Nativi-Nicolau, Candida Cristina Quarta, Claudio Rapezzi, Ronald Witteles, Giampaolo Merlini   +23 more
doaj   +1 more source

Quantitation of Tissue Amyloid via Fluorescence Spectroscopy Using Controlled Concentrations of Thioflavin-S

Molecules, 2023
Amyloids are misfolded proteins that aggregate into fibrillar structures, the accumulation of which is associated with the pathogenesis of many neurodegenerative diseases, such as Alzheimer’s disease (AD).
Tatiana P. MacKeigan, Megan L. Morgan, Peter K. Stys   +2 more
doaj   +1 more source

Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative. [PDF]

, 2018
IntroductionWe characterize long-term disease dynamics from cognitively healthy to dementia using data from the Alzheimer's Disease Neuroimaging Initiative.MethodsWe apply a latent time joint mixed-effects model to 16 cognitive, functional, biomarker ...
Aisen, Paul S, Donohue, Michael C, Iddi, Samuel, Li, Dan, Rafii, Michael S, Thompson, Wesley K   +5 more
core   +1 more source

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Journal of Neuroscience, 2006
Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD).
Holly Oakley, Sarah L. Cole, Sreemathi Logan, Erika Maus, Peizhen Shao, J. Craft, Angela L. Guillozet-Bongaarts, M. Ohno, J. Disterhoft, L. V. Van Eldik, R. Berry, R. Vassar   +11 more
semanticscholar   +1 more source

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

Acta Neuropathologica, 2021
Alzheimer’s disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau tangles and neuropil threads.
E. Gerrits, N. Brouwer, S. Kooistra, Maya E Woodbury, Y. Vermeiren, Mirjam Lambourne, J. Mulder, M. Kummer, T. Möller, K. Biber, W. Dunnen, P. D. de Deyn, B. Eggen, E. Boddeke   +13 more
semanticscholar   +1 more source

Prediction of peptide and protein propensity for amyloid formation [PDF]

, 2014
Understanding which peptides and proteins have the potential to undergo amyloid formation and what driving forces are responsible for amyloid-like fiber formation and stabilization remains limited.
A Quintas, A Trovato, A Trovato, AC Davison, AC Tsolis, Alexandre Quintas, AM Fernandez-Escamilla, AP Pawar, AV Finkelstein, B Rost, C Nerelius, Carlos Família, CM Dobson, D Eisenberg, David A. Phoenix, DJ Selkoe, DM Fowler, Eugene A. Permyakov, F Chiti, F Chiti, F Sasagawa, GG Tartaglia, GG Tartaglia, H Hu, I Cherny, I Walsh, IV Baskakov, J Palau, J Tian, JC Rochet, JD Sipe, JM Zimmerman, JW Kelly, JW Kelly, K Rajagopal, KF DuBay, KK Frousios, KT O’Neil, L Goldschmidt, LO Jimenez, M Belli, M Emily, M Hollander, M Kuhn, M López de la Paz, M Oliveberg, M Stefani, M Sunde, M Sunde, M Zamani, MB Kursa, MJ Thompson, MT Pastor, N Becker, N Qian, O Conchillo-Solé, PK Teng, PY Chou, RS Harrison, S Idicula-thomas, S Kawashima, S Kawashima, S Maurer-Stroh, S Ventura, S Yoon, S Yoon, Sarah R. Dennison, SJ Hamodrakas, SJ Hamodrakas, SK Maji, SO Garbuzynskiy, T Hothorn, T Hothorn, T Hothorn, T Scheibel, TPJ Knowles, VS Mathura, WH DePas, WT Astbury, Y Kallberg, Ž Eva   +80 more
core   +5 more sources

Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

New England Journal of Medicine, 2018
Background Transthyretin amyloid cardiomyopathy is caused by the deposition of transthyretin amyloid fibrils in the myocardium. The deposition occurs when wild‐type or variant transthyretin becomes unstable and misfolds. Tafamidis binds to transthyretin,
M. Maurer, J. Schwartz, B. Gundapaneni, P. Elliott, G. Merlini, M. Waddington-Cruz, A. Kristen, M. Grogan, R. Witteles, T. Damy, B. Drachman, Sanjiv J. Shah, M. Hanna, D. Judge, A. Barsdorf, P. Huber, T. Patterson, S. Riley, J. Schumacher, M. Stewart, M. Sultan, C. Rapezzi   +21 more
semanticscholar   +1 more source