Results 51 to 60 of about 516,976 (376)
The Development of an Early Diagnostic Method for Alzheimer’s Disease
ProceedingsAlzheimer’s disease (AD) is the most common form of dementia, characterized by neuronal degeneration and death [...]
Yulia K. Styufliaeva +3 more
doaj +1 more source
Frontiers in Human Neuroscience, 2022 IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment (MCI), the brain atrophy that may distinguish between three AT(N) biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI (sMRI) was employed ...
Miguel Ángel Rivas-Fernández +12 more
doaj +1 more source
A unifying framework for amyloid-mediated membrane damage: The lipid-chaperon hypothesis [PDF]
, 2021 Over the past thirty years, researchers have highlighted the role played by a class of proteins or polypeptides that forms pathogenic amyloid aggregates in vivo, including i) the amyloid Abeta peptide, which is known to form senile plaques in Alzheimer's disease; ii) alpha-synuclein, responsible for Lewy body formation in Parkinson's disease and iii ...
arxiv +1 more source
Cold Spring Harbor Perspectives in Biology, 2019 When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are usually associated with disease including Alzheimer's. However, amyloid has many useful features.
Otzen, Daniel, Riek, Roland
openaire +3 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Down syndrome: Distribution of brain amyloid in mild cognitive impairment
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI‐DS) and test these hypotheses using cross‐sectional and ...
David B. Keator +17 more
doaj +1 more source
Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice [PDF]
, 2005 BACKGROUND: The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense
Dickey, Chad A +5 more
core +3 more sources
Thorax, 1971 A 55-year-old housewife died from an illness characterized by progressive respiratory incapacity. Changes were confined to the lungs and consisted of a diffuse infiltration by amyloid. No adequate cause was found for this amyloid, and we suggest that this is a case of primary alveolar septal amyloidosis.
W. E. Zundel, A. P. Prior
openaire +2 more sources
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Yeast Approach in Amyloidogenic Proteins Study
ProceedingsSelf-reproducing protein aggregates of a fibrillar nature (amyloids) are associated with a number of animal and human diseases [...]
Andrew A. Zelinsky +3 more
doaj +1 more source