Crystallization of L‐Cysteine in Heavy Water Induces Intrinsic Fluorescence
Angewandte Chemie, EarlyView.Crystallization of L‐Cysteine in D2O${\rm D}_2{\rm O}$ generates a remarkably different structure compared to H2O${\rm H}_2{\rm O}$. The crystals formed in D2O${\rm D}_2{\rm O}$ display enhanced intrinsic fluorescence, and using state‐of‐the‐art excited state simulations, we determine the molecular origins of this luminescence and propose design ...
Debarshi Banerjee +10 more
wiley +2 more sources
Corrigendum to "Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency". [PDF]
Mol Genet Metab Rep, 2023 Rahhal S +14 more
europepmc +1 more source
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
Aggregate, EarlyView.This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky +3 more
wiley +1 more source
Human cystatin C induces the disaggregation process of selected amyloid beta peptides: a structural and kinetic view. [PDF]
Sci Rep, 2023 Żyła A +5 more
europepmc +1 more source
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. [PDF]
, 1993 D. E. Schmechel +8 more
openalex +1 more source
Genetics of Response to ECT, TMS, Ketamine and Esketamine
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Treatment‐resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined.
Clio E. Franklin +18 more
wiley +1 more source
Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. [PDF]
, 1994 Jan Näslund +9 more
openalex +1 more source
Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Annals of Neurology, EarlyView.Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel +10 more
wiley +1 more source
Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model. [PDF]
Int J Mol Sci, 2023 Liu J, Liu S, Zeng L, Tsilioni I.
europepmc +1 more source
Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies
Annals of Neurology, EarlyView.Objective Aggregation of misfolded α‐synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for aSyn “strains,” conformations with distinct biological properties, biomarkers for PD versus DLB are lacking.
George T. Kannarkat +17 more
wiley +1 more source