Results 121 to 130 of about 118,464 (350)

The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins

Biochemistry and Biophysics Reports
Signal peptides are a sequence of peptides located at the N-terminus of proteins and determine the protein secretion pathway and their destinations. The N-region is positively charged and influences the orientation of translocation.
Natalie G. Horgan, Anabela Djurovic-Topalovic, Taiwo A. Ademoye, Jessica S. Fortin   +3 more
doaj   +1 more source

Human cystatin C induces the disaggregation process of selected amyloid beta peptides: a structural and kinetic view. [PDF]

Sci Rep, 2023
Żyła A, Martel A, Jurczak P, Moliński A, Szymańska A, Kozak M.   +5 more
europepmc   +1 more source

The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide [PDF]

, 2003
Thomas Soucek, Robert C. Cumming, Richard Dargusch, Pamela Maher, David Schubert   +4 more
openalex   +1 more source

β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [PDF]

, 2004
β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase
Abramov, A.Y., Canevari, L., Duchen, M.R.   +2 more
core  

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Coenzyme Q10 Enhances Resilience of Mitochondrial-like Membranes Against Amyloidogenic Peptides

Membranes
Mitochondria possess a double-membrane envelope which is susceptible to insult by pathogenic intracellular aggregates of amyloid-forming peptides, such as the amyloid-beta (1-42) (Aβ42) peptide and the human islet amyloid polypeptide (hIAPP).
Raina Marie Seychell, Adam El Saghir, Gianluca Farrugia, Neville Vassallo   +3 more
doaj   +1 more source

Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model. [PDF]

Int J Mol Sci, 2023
Liu J, Liu S, Zeng L, Tsilioni I.
europepmc   +1 more source

Organic Electrochemical Transistors in Tissue‐Interfaced Bioelectronics

Advanced Science, EarlyView.
This article reviews the design, fabrication, and biological application of organic electrochemical transistors (OECTs), emphasizing their potential in tissue‐interfaced bioelectronics. It covers the fundamental principles of OECTs, strategies for enhancing tissue interfacing, and the development of skin‐mounted and implantable systems.
Ruixiang Bai, Zeyu Zhao, Feng Yan
wiley   +1 more source

Fully automated immunoassays for measuring beta‐amyloid peptide (1‐42) and total tau in cerebral spinal fluid [PDF]

, 2021
Daniel Kozo
openalex   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source