Results 121 to 130 of about 120,218 (348)

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Amyloid-beta 16-22 peptide dimer simulation (150 mM NaCl) with the CHARMM-Drude force field and OpenMM (Run 3)

, 2022
Batuhan Kav
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

O-glycosylated peptides curtail the aggregation and toxicity of human islet amyloid polypeptide

Communications Biology
A key pathogenetic pathway of type 2 diabetes (T2D) is pancreatic beta cell failure, losing their capability of producing insulin and regulating blood glucose.
Qian Zhang, Xiaohan Mei, Yan Li, Ziyang Wang, Ang Li, Dantong Liu, Sunil Kumar, Deling Kong, Andrew D. Hamilton, Chunqiu Zhang   +9 more
doaj   +1 more source

Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons. [PDF]

Biomedicines, 2023
Melo de Farias AR, Pelletier A, Iohan LCC, Saha O, Bonnefond A, Amouyel P, Delahaye F, Lambert JC, Costa MR.   +8 more
europepmc   +1 more source

Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine-v.4.0 [PDF]

, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I Baianu
core   +1 more source

Auditory evoked potentials might have the potential to serve as early indicators related to amyloid beta peptide toxicity

, 2020
Enis Hidişoğlu, Piraye Yargıçoğlu
openalex   +2 more sources

Concentration Dependent Transition of Membrane-Bound Beta-Stranded KIGAKI Peptides from Unstructured Monomers into Immobilized Amyloid Fibrils Observed by Solid-State 19F-NMR [PDF]

, 2013
Erik Strandberg, Parvesh Wadhwani, Jochen Bürck, Nico Heidenreich, Susanne Fanghänel, Anne S. Ulrich   +5 more
openalex   +1 more source

Modification of amyloid-beta peptide aggregation via photoactivation of strained Ru(ii) polypyridyl complexes

, 2021
Janaina C. Bataglioli, Luiza Moreira Gomes, Camille Maunoir, Jason R. Smith, Houston D. Cole, Julia McCain, Tariq Sainuddin, Colin G. Cameron, Sherri A. McFarland, Tim Storr   +9 more
openalex   +2 more sources

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source