Results 141 to 150 of about 109,107 (305)

A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site. [PDF]

Toxins (Basel), 2023
Futai E, Kawasaki H, Sato S, Daoudi K, Hidaka M, Tomita T, Ogawa T.   +6 more
europepmc   +1 more source

Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency. [PDF]

Mol Genet Metab Rep, 2023
Rahhal S, Farmer C, Thurm A, Wassif CA, Cawley NX, Perreault J, Dang Do A, Bianconi S, Hannah-Shmouni F, Guthrie W, Cubit LS, Miller JS, Sutton VR, Koeberl D, Porter FD.   +14 more
europepmc   +1 more source

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease

, 2008
The deposition of the amyloid β-protein (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD). Aβ-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Aβ-deposits occur first in
Griffin, W. Sue T., Braak, Heiko, Thal, Dietmar Rudolf   +2 more
core   +1 more source

Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood-Brain Barrier Endothelium. [PDF]

Mol Pharmacol, 2023
Wang Z, Sharda N, Omtri RS, Li L, Kandimalla KK.   +4 more
europepmc   +1 more source

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

, 2009
The role of microglial cells in the pathogenesis of Alzheimer’s disease (AD) neurodegeneration is unknown. Although several works suggest that chronic neuroinflammation caused by activated microglia contributes to neurofibrillary degeneration, anti ...
Streit, Wolfgang J., Xue, Qing-Shan, Ingo Bechmann, Bechmann, Ingo, Braak, Heiko, Wolfgang J. Streit, Heiko Braak, Qing-Shan Xue   +7 more
core   +1 more source

Opinion: The Potential Role of Amyloid Beta Peptides as Biomarkers of Subconcussion and Concussion. [PDF]

Front Neurol, 2022
Boutté AM, Thangavelu B, Anagli J.
europepmc   +1 more source

Amyloid beta peptides (Aβ) from Alzheimer's disease neuronal secretome induce endothelial activation in a human cerebral microvessel model. [PDF]

Neurobiol Dis, 2023
Shin YJ, Evitts KM, Jin S, Howard C, Sharp-Milgrom M, Schwarze-Taufiq T, Kinoshita C, Young JE, Zheng Y.   +8 more
europepmc   +1 more source

Insights into proton transfer dynamics in histidine tautomers of amyloid-β (1-40)

Communications Chemistry
Histidine tautomerization within amyloid beta (Aβ) peptides is crucial in understanding the molecular mechanisms underlying Alzheimer’s disease and its potential therapeutic strategies.
Yingqi Tang, Yoshifumi Nishimura, Nannan Li, Hai Li, Abbas Salimi, Kensuke Ishida, Aditya Wibawa Sakti, Hiromi Nakai, Rakesh Parida, Jin Yong Lee   +9 more
doaj   +1 more source

Plasma Aβ42 correlates positively with increased body fat in healthy individuals

, 2005
Obesity and overweight, well known risk factors for cardiovascular disease and type 2 diabetes, are now associated with Alzheimer's disease (AD). It remains to be determined if obesity and overweight contribute to the risk of developing AD through ...
Balakrishnana, K., Beilbye, J., Newton, Robert, Nolan, David, Martins, Ralph N., Newton, R., Mehta, P.D., Pankaj D. Mehta, David Nolan, Kelvin Balakrishnan, Galvão, Daniel A., Ralph N. Martins, Beilby, J., Gandy, Samuel E., Samuel E. Gandy, John Beilby, Giuseppe Verdile, Balakrishnan, Kelvin, Martins, R., Gandy, S., Verdile, G., Verdile, Giuseppe, Gandy, S.E., Galvao, D., Galvão, D.A., Nolan, D., Mehta, Pankaj D., Balakrishnan, K., Daniel A. Galvão, Beilby, John, Martins, R.N., Robert Newton, Mehta, P.   +32 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source