Results 121 to 130 of about 76,126 (160)

Amyloid beta peptides and glutamatergic synaptic dysregulation

Experimental Neurology, 2008
Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of glutamatergic synaptic ...
Kodeeswaran, Parameshwaran, Muralikrishnan, Dhanasekaran, Vishnu, Suppiramaniam   +2 more
openaire   +2 more sources

Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis

Current Alzheimer Research, 2006
Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4 ...
Mark A, Lovell, William R, Markesbery
openaire   +2 more sources

Natural human antibodies to amyloid beta peptide

Autoimmunity Reviews, 2008
Properties of human, natural anti-Abeta antibodies and commercially available intravenous immunoglobulin (IVIg) have been examined in light of the beneficial effects of passive immunotherapy with IVIg for patients with mild to moderate Alzheimer's disease (AD).
Paul, Szabo, Norman, Relkin, Marc E, Weksler   +2 more
openaire   +2 more sources

Effect of ferric citrate on amyloid‐beta peptides behavior

Biopolymers, 2018
AbstractAmyloid beta (Aβ) aggregation and oxidative stress are two of the central events in Alzheimer's Disease (AD). Both these phenomena can be caused by the interaction of Aβ with metal ions. In the last years the interaction between ZnII, CuII, and Aβ was much studied, but between iron and Aβ it is still little known.
Galante D, Cavallo E, Perico A, D'Arrigo C   +3 more
openaire   +2 more sources

Sequestration of amyloid beta-peptide.

Annals of the New York Academy of Sciences, 1993
Amyloid beta-protein, or beta/A4, is a 4-kilodalton peptide that forms poorly soluble extracellular depositions of amyloid in brains and leptomeninges of patients with Alzheimer's disease (AD), Down's syndrome (DS), and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D).
D, Goldgaber, A I, Schwarzman, R, Bhasin, L, Gregori, D, Schmechel, A M, Saunders, A D, Roses, W J, Strittmatter   +7 more
openaire   +1 more source

Cholesterol Modulates Amyloid Beta-peptide’s Membrane Interactions

Pharmacopsychiatry, 2003
The causal relationship between amyloid beta-peptide (Abeta) deposition and Alzheimer's disease (AD)-specific neuropathological lesions such as neurodegeneration and cortical atrophy is still not known. Mounting evidence points to alterations in cholesterol homeostasis occurring in AD brain that are probably linked to cerebral Abeta pathology ...
Gunter P, Eckert, Christopher, Kirsch, Steffen, Leutz, W Gibson, Wood, Walter E, Müller   +4 more
openaire   +2 more sources

Radiolabeling of Amyloid-β Peptides

2005
Nowadays, a wide variety of protocols for labeling proteins is available. However, radiolabeling remains one of the most powerful, sensitive and accurate methods to trace and quantitate proteins. Additionally, radiolabeling techniques are steadily gaining importance for diagnosis and treatment in nuclear medicine.
Miguel, Calero, Jorge, Ghiso
openaire   +2 more sources

[Structure of amyloid-beta peptides in a complex with model membranes].

Tsitologiia, 2014
Structures of amyloid-beta peptides Aβ1-40, Aβ10-35, Aβ13-23 and Aβ16-22 in a complex with model membranes in solution were obtained on the analysis of NMR experimental data. It has been established that the process of peptide-micelle complex formation occurs through the amino acid residues L17, F19, F20 and G29-M35.
Usachev K., Filippov A., Klochkov V.
openaire   +5 more sources

Amyloid-beta peptides are cytotoxic to oligodendrocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive dementia. Amyloid-beta peptide (Abeta), a 39-43 amino acid peptide derived from beta-amyloid precursor protein, forms insoluble fibrillar aggregates that have been linked to neuronal and vascular degeneration in AD and cerebral amyloid angiopathy.
J, Xu, S, Chen, S H, Ahmed, H, Chen, G, Ku, M P, Goldberg, C Y, Hsu   +6 more
openaire   +1 more source

Amyloid beta-peptide: the inside story.

Current Alzheimer research, 2005
The amyloid beta-peptide (Abeta) plays an early and critical role in the pathogenic cascade leading to Alzheimer's disease (AD). Abeta is typically found in extracellular amyloid plaques that occur in specific brain regions in the AD and Down syndrome brain.
Bertrand P, Tseng, Masashi, Kitazawa, Frank M, LaFerla   +2 more
openaire   +1 more source