Results 131 to 140 of about 109,107 (305)

Microglial Phagocytosis Assay

Bio-Protocol, 2016
Phagocytosis is essential for microglial clearance of apoptotic cells, extracellular protein aggregates, and infectious bacteria in the central nervous system (CNS).
Hong Lian, Ethan Roy, Hui Zheng
doaj   +1 more source

Human cystatin C induces the disaggregation process of selected amyloid beta peptides: a structural and kinetic view. [PDF]

Sci Rep, 2023
Żyła A, Martel A, Jurczak P, Moliński A, Szymańska A, Kozak M.   +5 more
europepmc   +1 more source

Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization

, 2013
Inflammatory processes are important in the pathogenesis of Alzheimer's disease and in response to amyloid-β immunotherapy. We investigated the expression of multiple inflammatory markers in the brains of 28 non-immunized patients with Alzheimer's ...
Cheaveau, M., Morgan, William, Cheaveau, Matthew, Boche, Delphine, Bharambe, V., Holmes, C., Love, S., Nicoll, James A R, Harris, Scott, Bharambe, Viraj, Neal, James W, Love, Seth, Nicoll, J.A.R., Zotova, E., Boche, D., Morgan, W., Neal, J.W., Holmes, Clive, Zotova, Elina   +18 more
core   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Recent Progress in Electrochemical Detection of Beta-amyloid Peptides and Their Aggregates

International Journal of Electrochemical Science, 2017
Beta-amyloid (Aβ) peptides and their aggregates are regarded as the promising biomarkers for Alzheimer's disease (AD) diagnosis. In this work, we focused on the recent progress in the development of electrochemical methods for the detection of Aβ ...
Ning Xia, Yong Chang, Yuanqiang Hao
doaj   +1 more source

Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model. [PDF]

Int J Mol Sci, 2023
Liu J, Liu S, Zeng L, Tsilioni I.
europepmc   +1 more source

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, EarlyView.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

Coenzyme Q10 Enhances Resilience of Mitochondrial-like Membranes Against Amyloidogenic Peptides

Membranes
Mitochondria possess a double-membrane envelope which is susceptible to insult by pathogenic intracellular aggregates of amyloid-forming peptides, such as the amyloid-beta (1-42) (Aβ42) peptide and the human islet amyloid polypeptide (hIAPP).
Raina Marie Seychell, Adam El Saghir, Gianluca Farrugia, Neville Vassallo   +3 more
doaj   +1 more source

Bri1 gene-related dementias; A morphological and biochemical study.

, 2006
Aspects of the neurodegenerative mechanism in AD remain unknown therefore studies on alternative models of cerebral amyloidosis, such as familial British dementia (FBD) and familial Danish dementia (FDD) may contribute to a better understanding of the ...
Lashley, T.
core  

O-glycosylated peptides curtail the aggregation and toxicity of human islet amyloid polypeptide

Communications Biology
A key pathogenetic pathway of type 2 diabetes (T2D) is pancreatic beta cell failure, losing their capability of producing insulin and regulating blood glucose.
Qian Zhang, Xiaohan Mei, Yan Li, Ziyang Wang, Ang Li, Dantong Liu, Sunil Kumar, Deling Kong, Andrew D. Hamilton, Chunqiu Zhang   +9 more
doaj   +1 more source