Results 171 to 180 of about 120,218 (348)

Sequence‐Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides

ChemistryEurope, EarlyView.
Two oppositely charged intrinsically disordered peptides (IDPs) coassemble into heterotypic nanofibers. Homochiral mixtures (L/L IDPs) form homogeneous, aligned bundles with the more positive IDP. Heterochiral mixtures (L/D IDPs) yield heterogeneous, twisted bundles as positive‐IDP content increases.
Yuchen Qiao, Matthew Chu, Grace Wu, Zhiyu Liu, Bing Xu   +4 more
wiley   +1 more source

Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease. [PDF]

Cells, 2020
Mo D, Li X, Raabe CA, Rozhdestvensky TS, Skryabin BV, Brosius J.   +5 more
europepmc   +1 more source

Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides. [PDF]

Int J Mol Sci, 2021
Frankowski H, Yeboah F, Berry BJ, Kinoshita C, Lee M, Evitts K, Davis J, Kinoshita Y, Morrison RS, Young JE.   +9 more
europepmc   +1 more source

Cu(I) Is a Game Changer in the Arrest of Cu(Aβ)‐Induced ROS Production in the Presence of Competing Zn(II) Ions

Chemistry – A European Journal, EarlyView.
ABSTRACT ROS production due to Cu(amyloid‐β) redox cycling is proposed to contribute to the oxidative stress observed in Alzheimer's disease brains. We previously reported on a nitrogen and sulfur‐containing ligand, L, able to arrest Cu(Aβ)‐induced ROS production [Chem. Eur. J. 2023, 29,].
Marielle Drommi, Kyangwi Patrick Malikidogo, Elena Atrián‐Blasco, Charlène Esmieu, Christelle Hureau   +4 more
wiley   +1 more source

Lipid/Polydiacetylene Vesicle Composition Alters Mutant Beta-Amyloid Peptide Interaction [PDF]

, 2017
Elizabeth A. Yates, Michael Dorsey, Brice M. Nguelifack   +2 more
openalex   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Xanthene Food Dye, as a Modulator of Alzheimer's Disease Amyloid-beta Peptide Aggregation and the Associated Impaired Neuronal Cell Function

, 2011
H. Edward Wong, Inchan Kwon
openalex   +2 more sources

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source