Results 171 to 180 of about 85,510 (321)

Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide [PDF]

, 2002
Joana Barbosa Melo, Paula Agostinho, Catarina R. Oliveira   +2 more
openalex   +1 more source

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Neurobiology of Disease, 2007
The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant   +8 more
doaj  

Hybrid pH Responsive Supramolecular Polymers Through the Combination of the Ureido–Pyrimidinone Motif with β‐Sheet Peptide Sequences

Chemistry – A European Journal, EarlyView.
The combination of the ureido–pyrimidinone motif with two different β‐sheet peptide sequences yielded supramolecular structures with significantly different morphologies in water. The resulting supramolecular nanostructures showed structural stability between pH = 5 and 9, while precipitation occurred at pH = 3.0 and random coil formation at pH 12 ...
Riccardo Bellan, David Attia, Marcel H. P. van Genderen, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.

, 1992
Jeroen Knops, Ivan Lieberburg, Sukanto Sinha   +2 more
openalex   +1 more source

A guide to selecting high-performing antibodies for amyloid-beta precursor protein for use in Western Blot, immunoprecipitation and immunofluorescence [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research
The amyloid-beta precursor protein is a transmembrane protein expressed in many tissues and highly concentrated in the brain. The protein is of significant interest due to its involvement in the generation of amyloidogenic β-amyloid peptides, prone to ...
Carl Laflamme, Kathleen Southern, Donovan Worrall, Riham Ayoubi, Maryam Fotouhi   +4 more
doaj  

Constant pH Molecular Dynamics Simulation of pH Effects on Amyloid‐β Structure, Dynamics, and Metal‐Binding

Chemistry – A European Journal, EarlyView.
Constant pH molecular dynamics simulations are used to examine the effect of pH on amyloid‐β and its complexes with Cu(II) and Zn(II). Changes in size and secondary structure are found, with suggestions for the origin of pH‐dependent aggregation. Abstract We report the first molecular dynamics simulations to examine the effect of pH on the structure ...
Thuraya Albrahadi, Christelle Hureau, James A. Platts   +2 more
wiley   +1 more source

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.

, 1991
James F. Flood, John E. Morley, E. Roberts   +2 more
openalex   +1 more source

The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide [PDF]

, 2003
Thomas Soucek, Robert C. Cumming, Richard Dargusch, Pamela Maher, David Schubert   +4 more
openalex   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides. [PDF]

Int J Mol Sci, 2021
Frankowski H, Yeboah F, Berry BJ, Kinoshita C, Lee M, Evitts K, Davis J, Kinoshita Y, Morrison RS, Young JE.   +9 more
europepmc   +1 more source