Results 191 to 200 of about 45,801 (303)

Polysaccharides from Basella alba Protect Post-Mitotic Neurons against Cell Cycle Re-Entry and Apoptosis Induced by the Amyloid-Beta Peptide by Blocking Sonic Hedgehog Expression [PDF]

Bo-Yu Hou, Ming-Hsuan Wu, Hui‐Yu Hsu, Yi‐Chun Lin, Ding‐I Yang   +4 more
openalex   +1 more source

Accumulation of Amyloid Beta (Aβ) Peptide on Blood Vessel Walls in the Damaged Brain after Transient Middle Cerebral Artery Occlusion [PDF]

, 2019
António A. Martins, Astrid Zayas‐Santiago, Yancy Ferrer‐Acosta, Solianne M. Martinez-Jimenez, Lidia Zueva, Amanda Díaz-García, Mikhail Inyushin   +6 more
openalex   +1 more source

Atrial cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala, Monika Przewłocka‐Kosmala   +1 more
wiley   +1 more source

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, EarlyView.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

, 2008
Elisabete Ferreiro, Catarina R. Oliveira, Cláudia Pereira   +2 more
openalex   +2 more sources

Progress in Defining Blood Biomarkers for Alzheimer's Disease Based on Biochemical Mass Spectrometry Platforms

Organ Medicine, EarlyView.
Alzheimer's disease diagnosis relies on costly, invasive positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) analysis, limiting clinical use. This review summarizes a blood‐based biochemical mass spectrometry platform for early Alzheimer's disease (AD) detection, with non‐invasiveness, high sensitivity (fg/mL level), high ...
Yujian Xie, Wenjun Cai, Xiuying Zhao, Runqing Li   +3 more
wiley   +1 more source

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani, Fei Fang, Scott E. Counts, Liangliang Sun   +3 more
wiley   +1 more source

O3–01–04: Determination of beta–amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation–mass spectrometry [PDF]

, 2006
Erik Portelius, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow   +3 more
openalex   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

Amyloid Beta peptides induce phosphatidylocholine hydrolysis in immortalized rat brain endothelial cells and bovine retina pericytes

, 2001
Mario Alberghina
openalex   +1 more source