Results 271 to 280 of about 120,218 (348)

The Development of a Model to Predict Cognitive Decline Within 12 Months in Home Care Clients

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To develop and validate a model to predict cognitive decline within 12 months for home care clients without a diagnosis of dementia. Design We included all adults aged ≥ 18 years who had at least two interRAI Home Care assessments within 12 months, no diagnosis of dementia and a baseline Cognitive Performance Scale score ≤ 1.
Gary Cheung, Ruth Teh, Eamon Merrick, Nicole Williams, Dawn M. Guthrie   +4 more
wiley   +1 more source

Amyloid [beta]-peptide and tau in the diagnosis and pathogenesis of Alzheimer's disease

, 1999
Malene Jensen
openalex  

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, EarlyView.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Designing novel peptides with amyloid-<i>β</i> binding and clearance potential using BiLSTM and molecular dynamics. [PDF]

Front Artif Intell
Yata VK, Das OP, Dansana J, Gadtya A, Meher BR, Bukke SPN, Kolliputi N.   +6 more
europepmc   +1 more source

Globus Pallidus Iron Relates to Cognitive Impairment in Alzheimer's Disease: Evidence From MRI‐Based Meta‐Analysis

Annals of the New York Academy of Sciences, EarlyView.
Iron is crucial for brain functioning, but excessive levels can harm brain health. While previous studies support this, meta‐analytic evidence in Alzheimer's disease (AD) is limited. We performed a meta‐analysis of 23 MRI studies with 715 AD patients and 1130 healthy controls.
Marthe Mieling, Clara Wiskow, Nico Bunzeck   +2 more
wiley   +1 more source

Comprehensive profiling of Aβ40 and Aβ42 fibril-interacting proteins reveals PRKCG as a drug-targetable regulator of amyloidogenesis in Alzheimer's disease. [PDF]

Alzheimers Dement
Montero-Calle A, Coronel R, Manosalva J, Megías D, de Los Ríos V, Rábano A, Peláez-García A, Martínez-Useros J, Fernández-Aceñero MJ, Liste I, Barderas R.   +10 more
europepmc   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source