Results 271 to 280 of about 45,801 (303)
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Monitoring the amyloid beta-peptide in vivo – caveat emptor
Drug Discovery Today, 2009As a wave of 'disease modifying' (DM) therapies for Alzheimer's disease (AD) progresses towards the later stages of clinical development, an evaluation of our ability to measure relevant pharmacodynamic effects of such therapies is warranted. Reducing accumulation of amyloid beta (Abeta)-peptide in the brain parenchyma is the primary objective of most ...
Paul W, Thompson, Andrew, Lockhart
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Interfacial Effects on the Conformation of Amyloid-Beta Peptide
Protein & Peptide Letters, 2009We examined the effects of air-water and water-sevoflurane interfaces on conformational properties of amyloid-beta peptide (ABP). Fractions were extracted from sub-interfacial (air-water) and supra-interfacial (water-sevoflurane) layers and compared with aqueous bulk layers using fluorescence properties of ABP provided by a single tyrosine.
Norbert W, Seidler, Joshua D, Eklund
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Amyloid beta-peptide: the inside story.
Current Alzheimer research, 2005The amyloid beta-peptide (Abeta) plays an early and critical role in the pathogenic cascade leading to Alzheimer's disease (AD). Abeta is typically found in extracellular amyloid plaques that occur in specific brain regions in the AD and Down syndrome brain.
Bertrand P, Tseng +2 more
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Interaction of Calreticulin with Amyloid Beta Peptide 1-42
Protein & Peptide Letters, 2008The interaction of calreticulin with amyloid beta (Abeta) was investigated using solid phase and solution binding assays. Calreticulin bound Abeta 1-42 in a time and concentration dependent fashion. The binding was optimal at pH 5 and was stimulated by Ca2+ and inhibited by Zn2+ at pH 7.
Duus, K., Hansen, Paul Robert, Houen, G.
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Amyloid beta peptide-activated signal pathways in human platelets
European Journal of Pharmacology, 2008Amyloid beta peptide (amyloid-beta), which accumulates in the cerebral microvessels in an age-dependent manner, plays a key role in the pathogenesis of cerebral amyloid angiopathy. Platelets are an important cellular element in vasculopathy of various causes. Amyloid-beta may activate or potentiate platelet aggregation.
Ming Y, Shen +7 more
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Amyloid-beta peptides are cytotoxic to oligodendrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive dementia. Amyloid-beta peptide (Abeta), a 39-43 amino acid peptide derived from beta-amyloid precursor protein, forms insoluble fibrillar aggregates that have been linked to neuronal and vascular degeneration in AD and cerebral amyloid angiopathy.
J, Xu +6 more
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Amyloid Beta Peptide Processing, Insulin Degrading Enzyme, and Butyrylcholinesterase
Neurochemical Research, 2001Amyloid beta peptide implicated in Alzheimers disease is cleaved by insulin degrading enzyme (IDE). Abnormal cholinesterases similar to butyrylcholinesterase (BChE) are found in Alzheimer brain. The similarities between IDE and BChE (which is known to have an arylacylamidase and a metallocarboxypeptidase-like activity) such as their zinc metalloenzyme ...
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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Nature Reviews Drug Discovery, 2022Eric Karran, Bart De Strooper
exaly
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Signal Transduction and Targeted Therapy, 2023Weihong Song
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