Results 131 to 140 of about 94,035 (378)
Golgi Fragmentation in Alzheimer’s Disease
Frontiers in Neuroscience, 2015 The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology.
Gunjan eJoshi +3 more
doaj +1 more source
Correlating familial Alzheimer’s disease gene mutations with clinical phenotype [PDF]
, 2010 Alzheimer’s disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it.
Rossor, M.N., Ryan, N.S.
core +1 more source
Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage [PDF]
, 2016 Fe65 undergoes a phosphatase-sensitive gel mobility shift after DNA damage, consistent with protein phosphorylation. A recent study identified Ser228 as a specific site of phosphorylation, targeted by the ATM and ATR protein kinases, with phosphorylation
Blain, Peter G. +3 more
core +2 more sources
Frontiers in Aging Neuroscience, 2012 The Morris swim navigation task (‘water maze’) has been a primary research tools to assess hippocampal delpendent spatial learning and memory is rodents for three decades. Originally developed for rats, its application to mouse studies has been a tedious
Heikki eTanila
doaj +1 more source
New Insights in the Amyloid-Beta Interaction with Mitochondria
Journal of Aging Research, 2012 Biochemical and morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer’s disease (AD). Particularly, mitochondrial dysfunction is a hallmark of amyloid-beta-induced neuronal toxicity in Alzheimer’s disease ...
Carlos Spuch +2 more
doaj +1 more source
Journal of the Association for Information Science and Technology, EarlyView.Abstract Concerns over research integrity are rising, with increasing attention to potential threats from untrustworthy authors. We established a framework to gauge the potential negative influence of researchers potentially engaged in misconduct. The field of Alzheimer's disease (AD) research has been a focal point of these worries. This study aims to
Chaoqun Ni, B. Ian Hutchins
wiley +1 more source
Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer’s disease
Frontiers in Physiology, 2012 Since the discovery of prion diseases, the concept that a transmissible pathogen could be a protein has emerged. As such, this transmissible protein agent can transfer its pathological mis-folded shape to the same but normally folded protein thus leading
Valerie eVingtdeux +2 more
doaj +1 more source
Mechanical Characterization of Amyloid Fibrils Using Coarse-Grained Normal Mode Analysis [PDF]
Advanced Functional Materials 2011, 2011 Recent experimental studies have shown that amyloid fibril formed by aggregation of {\beta} peptide exhibits excellent mechanical properties comparable to other protein materials such as actin filaments and microtubules. These excellent mechanical properties of amyloid fibrils are related to their functional role in disease expression.
arxiv
BioEssays, EarlyView.Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley +1 more source
APP Causes Hyperexcitability in Fragile X Mice
Frontiers in Molecular Neuroscience, 2016 Amyloid-beta protein precursor (APP) and metabolite levels are altered in fragile X syndrome (FXS) patients and in the mouse model of the disorder, Fmr1KO mice.
Cara Jean Westmark +8 more
doaj +1 more source