Results 311 to 320 of about 122,310 (350)

Alzheimer amyloid beta-protein precursor in sperm development.

The American journal of pathology, 1990
We prepared antisera to both the N and C termini of amyloid beta-protein precursor (APP). Both antisera labeled 110 to 140 kd proteins from rat testis by immunoblotting. Northern blot analysis using oligonucleotide probes complementary to respective APPs showed that APPs expressed in rat testis contained Kunitz-type protease inhibitor domains ...
M, Shoji, T, Kawarabayashi, Y, Harigaya, H, Yamaguchi, S, Hirai, T, Kamimura, T, Sugiyama   +6 more
openaire   +1 more source

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

Science, 1990
Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by extensive amyloid deposition in the small leptomeningeal arteries and cortical arterioles, which lead to an early death of those afflicted in their fifth or sixth decade ...
Van Broeckhoven, Christine, Haan, J., Bakker, E., Hardy, J.A., Vanhul, W., Wehrert, A., Vegter-Van der Vlis, M., Roos, R.A.C.   +7 more
openaire   +3 more sources

Low cerebrospinal-fluid concentrations of soluble amyloid $beta;-protein precursor in hereditary Alzheimer's disease

The Lancet, 1992
In Alzheimer's disease, deposits of amyloid beta-protein are apparently derived from intracellular processing of a large precursor protein. We have measured concentrations of this precursor in cerebrospinal fluid (CSF) from six members of a family affected by presenile Alzheimer's disease associated with a point mutation of the precursor gene. One gene
M, Farlow, B, Ghetti, M D, Benson, J S, Farrow, W E, van Nostrand, S L, Wagner   +5 more
openaire   +2 more sources

Detection of amyloid beta protein precursor immunoreactivity in normal and Alzheimer's disease cerebrospinal fluid

Life Sciences, 1990
The amyloid A4 (or beta protein), a 4.2 kD polypeptide, is a major component of amyloid deposits in the brains of patients with Alzheimer's Disease (AD). The self-aggregating amyloid A4 protein of AD is encoded as part of three larger proteins by the amyloid A4 precursor gene. The corresponding proteins have 695, 751 and 770 amino acid residues.
J K, Chong, B E, Miller, H A, Ghanbari
openaire   +2 more sources

Secretion Kinetics of Alzheimer′s Amyloid β-Protein Differs from Secreted β-Amyloid Precursor Protein

Biochemical and Biophysical Research Communications, 1995
Amyloid beta-protein (A beta) and secreted beta-amyloid precursor protein (sAPP), derived from beta-amyloid precursor protein (APP), are normally released by cultured mammalian cells. We investigated by pulse-chase analysis the secretion kinetics of these two APP derivatives using mouse cholinergic SN49 cell lines stably transfected with mouse APP695 ...
W, Araki, T, Kunishita, K, Takahashi, S, Ikeda, T, Tabira   +4 more
openaire   +2 more sources

Studies of Amyloid β‐Protein Precursor Expression in Alzheimer's Disease

Annals of the New York Academy of Sciences, 1991
The generation of the beta/A4 peptide and its accumulation into insoluble amyloid deposits represent key events in the neuropathologic process of Alzheimer's disease (AD). This posit has gained further support from recent reports that beta/A4 is directly responsible for the death of neurons. Potential therapies for AD aimed at abating the production of
R E, Tanzi, B T, Hyman
openaire   +2 more sources

A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor

Nature Medicine, 2000
The amyloid beta-protein precursor gives rise to the amyloid beta-protein, the principal constituent of senile plaques and a cytotoxic fragment involved in the pathogenesis of Alzheimer disease. Here we show that amyloid beta-protein precursor was proteolytically cleaved by caspases in the C terminus to generate a second unrelated peptide, called C31 ...
D C, Lu, S, Rabizadeh, S, Chandra, R F, Shayya, L M, Ellerby, X, Ye, G S, Salvesen, E H, Koo, D E, Bredesen   +8 more
openaire   +2 more sources

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

Science, 1994
Normal processing of the amyloid β protein precursor (βAPP) results in secretion of a soluble 4-kilodalton protein essentially identical to the amyloid β protein (Aβ) that forms insoluble fibrillar deposits in Alzheimer's disease.
N, Suzuki, T T, Cheung, X D, Cai, A, Odaka, L, Otvos, C, Eckman, T E, Golde, S G, Younkin   +7 more
openaire   +2 more sources

Functional Roles of Amyloid-β Protein Precursor and Amyloid-β Peptides: Evidence from Experimental Studies

Journal of Alzheimer's Disease, 2009
Amyloid-β (Aβ) has remained a central feature in research into Alzheimer's disease (AD). Yet the function of the amyloid-β protein precursor (AβPP) and its processing products in the central nervous system is controversial. This review examines experimental literature from cell cultures to transgenic AD and brain injury models with a special emphasis ...
Mikko, Hiltunen, Thomas, van Groen, Jukka, Jolkkonen   +2 more
openaire   +2 more sources

Widespread expression of amyloid beta-protein precursor gene in rat brain.

The American journal of pathology, 1989
The neuritic plaque is a characteristic finding in Alzheimer's disease. A major component of the plaque core is a 4.2 kd polypeptide, amyloid beta-protein (ABP), which is derived from the C-terminus of a larger precursor protein (ABPP). The authors have studied the transcription of ABPP mRNA in the adult rat brain by Northern analysis and in situ ...
S, Mita, E A, Schon, J, Herbert
openaire   +1 more source