Results 321 to 330 of about 94,035 (378)

Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications, 1989
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
Tsunao Saitoh, Tilman Oltersdorf, David Schubert, Greg M. Cole   +3 more
openaire   +3 more sources

Genomic organization of the human-amyloid beta-protein precursor gene

Gene, 1990
Amyloid beta-protein (BP) deposited in Alzheimer brains is a cleavage product of a larger precursor (BPP). The BPP gene encodes three types of mRNA generated by alternative splicing, two of which contain the sequence encoding Kunitz-type serine-protease inhibitor (serpin).
Katsumi Doh-ura, Hiroyuki Sasaki, Shun ichi Yoshikai, Yoshiyuki Sakaki, Hirokazu Furuya   +4 more
openaire   +3 more sources

Amyloid β protein toxicity mediated by the formation of amyloid‐β protein precursor complexes

Annals of Neurology, 2003
AbstractThe amyloid‐β protein precursor, a type 1 transmembrane protein, gives rise to the amyloid β‐protein, a neurotoxic peptide postulated to be involved in the pathogenesis of Alzheimer's disease. Here, we show that soluble amyloid β protein accelerates amyloid precursor protein complex formation, a process that contributes to neuronal cell death ...
Eliezer Masliah, Dale E. Bredesen, Gideon M. Shaked, Edward H. Koo, Daniel C. Lu   +4 more
openaire   +2 more sources

Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor

Journal of Alzheimer's Disease, 2002
Amyloid beta (Abeta) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Abeta peptides can inhibit the effect of insulin on the metabolic processing of the amyloid beta protein precursor (AbetaPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and ...
Marco Racchi, Erik Helmerhorst, Suzanne Craft, Xie Ling, Ralph N. Martins   +4 more
openaire   +3 more sources

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Science, 1993
The 4-kilodalton amyloid βprotein (Aβ), which forms fibrillar deposits in Alzheimer's disease (AD), is derived from a large protein referred to as the amyloid β protein precursor (βAPP). Human neuroblastoma (M17) cells transfected with constructs expressing wild-type βAPP or a mutant, βAPP ΔNL , recently linked to ...
Xiao Dan Cai, Todd E. Golde, Steven G. Younkin   +2 more
openaire   +3 more sources

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

Essays in Biochemistry, 2002
The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases.
David H. Small, Janelle Nunan
openaire   +3 more sources

Localization of Alzheimer Amyloid Beta Protein Precursor and Its Relation to Senile Plaque Amyloid

Gerontology, 1994
The authors examined the ultrastructural localization of amyloid beta protein precursor (APP) in normal human brains immunohistochemically using 3 kinds of APP antisera. The patterns of immunoreaction differed between the antisera used. Antiserum 770, against APP1-770, predominantly labeled the cytoplasm of neurons, whereas antiserum Z31, against the ...
Shunsaku Hirai, Tsuyoshi Kawarabayashi, Haruyasu Yamaguchi, Yasujirou Sakai, Xaoyan Sun, Tsuneo Yamazaki   +5 more
openaire   +3 more sources

Expression of amyloid beta-protein precursor mRNAs in familial Alzheimerʼs disease

NeuroReport, 1991
The amyloid beta-protein precursor (APP) gene and its products are implicated in the pathogenesis of Alzheimer's disease. The differential expression of APP transcripts may contribute to this process. In the present study, the distribution of mRNAs encoding APP variants has been determined in the brain of three cases of familial Alzheimer's disease ...
A.J.L. Barton, Paul Harrison, R. C. A. Pearson   +2 more
openaire   +3 more sources

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Biochemical and Biophysical Research Communications, 1987
The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a
Hiroyuki Sasaki, Ikuo Goto, Yoshiyuki Sakaki, Takashi Miyata, Hirokazu Furuya, Takeshi Yamada   +5 more
openaire   +3 more sources