Results 321 to 330 of about 122,310 (350)

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

Annual Review of Cell Biology, 1994
BIOCHEMICAL ANALYSES OF ALZHEIMER BRAIN LESIONS LEAD TO THE IDENTIFICATION OF A AND ITS PRECURSOR . . . . . . . . . . . . . . . . . . . 374 The Histopathology of Alzheimer's Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 374 Characterization of A and pp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
openaire   +2 more sources

A novel mutation in the beta-protein coding region of the amyloid beta-protein precursor (APP) gene.

Human genetics, 1992
A novel mutation, a C to T transition at base pair 2124 in exon 17 of the amyloid beta-protein precursor (APP) gene, has been identified by direct sequencing of amplified DNA from two Alzheimer's disease (AD) patients. A simple oligonucleotide-hybridization procedure was developed to allow population studies of this DNA variation.
M, Balbín, M, Abrahamson, L, Gustafson, K, Nilsson, A, Brun, A, Grubb   +5 more
openaire   +1 more source

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Chemical Reviews, 2021
Phuong H Nguyen, Ayyalusamy Ramamoorthy, Bikash Sahoo   +2 more
exaly  

The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein

Biological Psychiatry, 1996
S.G. Younkin, X.H. Song, D. Scheuner, C. Eckman, C-M Prada, J. Jensen, L. Lannfelt, J. Hardy, R. Tanzi, G. Schellenberg, D. Selkoe, N. Suzuki   +11 more
openaire   +1 more source

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes

Chemical Reviews, 2021
Danilo Milardi, Ehud Gazit, Sheena E Radford   +2 more
exaly  

Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease.

Annals of the New York Academy of Sciences, 1993
The approximately 4 kD (39-43 amino acid) polypeptide (amyloid beta protein, A beta) deposited as amyloid in Alzheimer's disease (AD) is derived from a set of 695-770 residue precursor proteins collectively referred to as the amyloid beta-protein precursor (beta APP).
T E, Golde, X D, Cai, M, Shoji, S G, Younkin   +3 more
openaire   +1 more source

Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids

Chemical Reviews, 2021
Dieter Willbold, Birgit Strodel, Gunnar F. Schröder   +2 more
exaly  

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

Nature Reviews Drug Discovery, 2022
Eric Karran, Bart De Strooper
exaly  

THE AMYLOID BETA PROTEIN PRECURSOR GENE CONTAINS A COMPLEX TRANSCRIPTIONAL UNIT

Alzheimer Disease & Associated Disorders, 1988
J. W. TEENER, D. GOLDGABER, J. R. GILBERT, A. D. ROSES, D. C. GAJDUSEK   +4 more
openaire   +1 more source

5200339 Proteases causing abnormal degradation of amyloid beta-protein precursor

Biotechnology Advances, 1994
openaire   +2 more sources