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Amyloid β Protein Precursor Is Possibly a Heparan Sulfate Proteoglycan Core Protein [PDF]

Science, 1988
The amyloid β protein peptide is a major constituent of amyloid plaque cores in Alzheimer's disease and is apparently derived from a higher molecular weight precursor. It is now shown that the core protein of a heparan sulfate proteoglycan secreted from a nerve cell line (PC12) has an amino acid sequence and a size very similar to those of the amyloid ...
Tsunao Saitoh, Greg M. Cole, Rolly Schroeder, Monique Lacorbiere, David Schubert   +4 more
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Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity

Journal of Neurochemistry, 2003
AbstractThe amyloid β‐protein precursor (APP) is proteolytically cleaved to generate the amyloid β‐protein (Aβ), the principal constituent of senile plaques found in Alzheimer's disease (AD). In addition, Aβ in its oligomeric and fibrillar forms have been hypothesized to induce neuronal toxicity.
Daniel C. Lu, Salvador Soriano, Edward H. Koo, Dale E. Bredesen   +3 more
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Pathogenic Effects of Cerebral Amyloid Angiopathy Mutations in the Amyloid β‐Protein Precursor

Annals of the New York Academy of Sciences, 2002
Abstract: Cerebral amyloid β‐protein angiopathy (CAA) is a key pathological feature of patients with Alzheimer's disease and certain related disorders. Several mutations have been identified within the Aβ region of the Aβ protein precursor (AβPP) gene that appear to enhance the severity of CAA.
Jerry P. Melchor, Judianne Davis, Galina Romanov, Kelly Zeigler, William E. Van Nostrand   +4 more
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Alzheimer amyloid beta-protein precursor in sperm development.

The American journal of pathology, 1990
We prepared antisera to both the N and C termini of amyloid beta-protein precursor (APP). Both antisera labeled 110 to 140 kd proteins from rat testis by immunoblotting. Northern blot analysis using oligonucleotide probes complementary to respective APPs showed that APPs expressed in rat testis contained Kunitz-type protease inhibitor domains ...
M, Shoji, T, Kawarabayashi, Y, Harigaya, H, Yamaguchi, S, Hirai, T, Kamimura, T, Sugiyama   +6 more
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Structure and Expression of mRNA for the Mouse Homolog of Alzheimer Amyloid Beta Protein Precursor

1990
In the brain of patients with Alzheimer’s disease (AD), fibrillar amyloid is deposited as senile plaque core and cerebrovascular amyloidl(1,2). The beta protein or A4 protein is a major constituent of this amyloid and is now known to be the cleavage product of a larger precursor protein (BPP) which has features characteristic of glycosylated cell ...
Yoshiyuki Sasaki, Ikuo Goto, Hiroyuki Sasaki, Hirokazu Furuya, Takeshi Yamada, Ryutaro Izumi   +5 more
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Proteolytic processing of amyloid β protein precursor (APP) by thrombin

Biochemical and Biophysical Research Communications, 1992
Search for proteases responsible for an altered processing of APP which generates intermediates containing beta/A4 peptide is preceding to understand the formation of beta amyloid deposits characteristic of Alzheimer's disease, since many studies reveal that APP is ordinarily processed so as not to generate beta amyloid.
Kenji Igarashi, Hitoshi Murai, Junichiro Asaka   +2 more
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Thiophilic Interaction Chromatography (TIC) of Amyloid-β Protein Precursor

Journal of Alzheimer's Disease, 2007
Neuritic plaques, one of the diagnostic characteristics of an AD, contain extracellular deposits of amyloid-beta (Abeta) derived from amyloid-beta protein precursor (AbetaPP). The objective of this study was to extract AbetaPP out of HEK293 cells and to purify it.
Thamarapu Srikrishnan, Derek Oyston, Tara Johnson, Mustapha Bourhim   +3 more
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Cytoplasmic Tail Adaptors of Alzheimer's Amyloid-β Protein Precursor

Molecular Neurobiology, 2004
Alzheimer's disease is characterized pathologically by senile plaques in the brain. The major component of senile plaques is amyloid-beta (Abeta), which is cleaved from Alzheimer's Abeta protein precursor (AbetaPP). Recently, information regarding the cytoplasmic tail of AbetaPP has started to emerge, opening up various insights into the physiological ...
Ikuo Nishimoto, Masaoki Kawasumi, Shuji Matsuda, Masaaki Matsuoka   +3 more
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Magnesium Modulates Amyloid-β Protein Precursor Trafficking and Processing

Journal of Alzheimer's Disease, 2010
Alzheimer's disease (AD), the most common form of dementia, is characterized by the presence of excessive deposits of aggregated amyloid-beta (Abeta), which is derived from the amyloid-beta protein precursor (AbetaPP) following processing by beta- and gamma-secretase. Metal elements are implicated in the pathophysiology of AD.
Xuemin Xu, Zheng Chen, Jiangyang Lu, Yi Liu, Jia Yu, Liang Zhou, Dongsheng Fan, Miao Sun, Dehua Chui   +8 more
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Low cerebrospinal-fluid concentrations of soluble amyloid $beta;-protein precursor in hereditary Alzheimer's disease

The Lancet, 1992
In Alzheimer's disease, deposits of amyloid beta-protein are apparently derived from intracellular processing of a large precursor protein. We have measured concentrations of this precursor in cerebrospinal fluid (CSF) from six members of a family affected by presenile Alzheimer's disease associated with a point mutation of the precursor gene. One gene
Bernardino Ghetti, J.S. Farrow, W E Van Nostrand, Merrill D. Benson, Steven L. Wagner, Martin R. Farlow   +5 more
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