Results 141 to 150 of about 249,317 (377)
Mechanochemistry: Fundamental Principles and Applications
Advanced Science, EarlyView.In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong +4 more
wiley +1 more source
Three-Dimensional Amyloid-Beta PET Synthesis from Structural MRI with Conditional Generative Adversarial Networks [PDF]
arXivMotivation: Alzheimer's Disease hallmarks include amyloid-beta deposits and brain atrophy, detectable via PET and MRI scans, respectively. PET is expensive, invasive and exposes patients to ionizing radiation. MRI is cheaper, non-invasive, and free from ionizing radiation but limited to measuring brain atrophy.
arxiv
Advanced Science, EarlyView.In situ Cell‐type‐specific proteome Analysis using antibody‐mediated Biotinylation (iCAB) is a method that directly targets and analyzes proteins in specific cell types within tissue. Applied to 5xFAD mice, iCAB identifies ≈8000 cell‐type‐specific proteins, revealing unique pathways in neurons, astrocytes, and microglia.
Taekyung Ryu +6 more
wiley +1 more source
X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation [PDF]
, 1986 openalex +1 more source
Advanced Science, EarlyView.BF‐PVA porous film is prepared by doping BF into PVA to form hydrogel and then freeze‐drying and compression to improve the tensile resistance, bending resistance, swelling resistance, degradation time and electrical properties of PVA. Finally, the degradable triboelectric sensor made of BF‐PVA porous film and Mg film is used to realize the signal ...
Yichang Quan +11 more
wiley +1 more source
Protective Effect of Trehalose Sugar on Amyloid-Membrane Interactions using BLM Electrophysiology [PDF]
Alzheimer's disease (AD) is a neurodegenerative disease characterized by dementia and memory loss in the elderly population. The amyloid-$\beta$ peptide (A$\beta$ 1-42) is one of the main pathogenic factors in AD and is known to cause damage to neuronal cellular membranes.
arxiv +1 more source
Advanced Science, EarlyView.Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du +8 more
wiley +1 more source
Serotonergic Signaling Pathways that Suppress Amyloid Beta in Mouse Models of AD [PDF]
, 2014 A diagnosis of Alzheimer\u27s disease is one of the most devastating things one can hear. This terrible disease robs people of their ability to remember cherished events as their brains become riddled with beta amyloid plaques.
Fisher, Jonathan Robert
core +1 more source
Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. [PDF]
, 1993 Nelson Arispe +2 more
openalex +1 more source
An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis
Advanced Science, EarlyView.The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari +20 more
wiley +1 more source