Results 151 to 160 of about 1,555,922 (344)

The Effect of Amyloid Beta on Synapses

, 2019
Alzheimer's disease (AD) is a neurodegenerative disease that leads to cognitive deficits. The brain dysfunction in AD is marked by an increase in amyloid-beta, the protein responsible for plaque deposition in the brain.
Frediani, Gabrielle
core  

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Associating Cognition With Amyloid Status Using Partially Ordered Set Analysis

Frontiers in Neurology, 2019
Background: The presence of brain amyloid-beta positivity is associated with cognitive impairment and dementia, but whether there are specific aspects of cognition that are most linked to amyloid-beta is unclear.
Sarah J.A. Carr, Sarah J.A. Carr, Judith Jaeger, Judith Jaeger, Shijia Bian, Ping He, Nancy Maserejian, Wenting Wang, Paul Maruff, Paul Maruff, Ahmed Enayetallah, Yanming Wang, Zhengyi Chen, Alan Lerner, Alan Lerner, Curtis Tatsuoka, Curtis Tatsuoka, Curtis Tatsuoka, Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing   +18 more
doaj   +1 more source

The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity

Neural Regeneration Research, 2013
Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to ...
Wang, Xu, Yang, Yi, Jia, Mingyue, Ma, Chi, Wang, Mingyu, Che, Lihe, Yang, Yu, Wu, Jiang   +7 more
openaire   +2 more sources

Association of Cerebral Amyloid-beta Aggregation With Cognitive Functioning in Persons Without Dementia

, 2018
Importance: Cerebral amyloid-beta aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the ...
Fagan, A.M., Madsen, K., Alcolea, D., Nordberg, A., Spiru, L., Waldemar, G., Alexander, M., Scheltens, P., Rodríguez-Rodríguez, E., Zboch, M., Drzezga, A., Leon, M., Freund-Levi, Y., Herukka, S.K., Sarazin, M., Hellwig, S., Kohler, S., Chetelat, G., Aalten, P., Ivanoiu, A., Johannsen, P., Teunissen, C.E., Forster, S., Novak, G.P., Sanchez-Juan, P., Blennow, K., Verhey, F.R.J., van Buchem, M.A., Chipi, E., Gkatzima, O., Klunk, W.E., Meulenbroek, O., Mroczko, B., Almdahl, I.S., Fladby, T., Stomrud, E., Møllergård, H.M., Struyfs, H., van Waalwijk van Doorn, LJC, Camus, V., Lleo, A., Frederiksen, K.S., van der Flier, W.M., Baldeiras, I., Hildebrandt, H., Froelich, L., Chen, K., Koglin, N., Lisetti, V., Rowe, C.C., Gordon, M.F., Kornhuber, J., Mollergard, H.M., Cavedo, E., Vos, SJB, Newberg, A., Wolk, D.A., Aarsland, D., Hampel, H., Roe, C.M., Vandenberghe, R., Parnetti, L., Peters, O., Verhey, FRJ, Verbeek, M.M., Tijms, B.M., Mintun, M.A., Kramberger, M.G., Rot, U., Zetterberg, H., Villemagne, V.L., Mattsson, N., Morris, J.C., Soininen, H., Laere, K. Van, Brooks, D.J., Ossenkoppele, R., de Mendonça, A., Wallin, Å.K., Grimmer, T., Landau, S.M., Sabri, O., Na, D.L., Rinne, J.O., Rüther, E., Fleisher, A.S., Kapaki, E., Buchem, M.A. van, Meyer, P.T., Hausner, L., Schröder, J., Rabinovici, G.D., Berckel, B.N. van, Frisoni, G.B., Ramakers, I., et al., Ramakers, IHGB, Rami, L., Gabryelewicz, T., Mendonca, A. de, Fortea, J., Flier, W.M. van der, Wallin, A., Jansen, W.J., Visser, P.J., Maier, W., Hansson, O., Cohen, A.D., Lee, D.Y., van Laere, K., van Berckel, BNM, Wiltfang, J., Paraskevas, G.P., Mok, V., Arnold, S.E., Marcusson, J., Tsolaki, M., Oliveira, C. de, Barthel, H., Santana, I., Klimkowicz-Mrowiec, A., Molinuevo, J.L., Engelborghs, S., Resende de Oliveira, C., Nordlund, A., Perera, G., de Leon, M., Popp, J., Jagust, W.J., Seo, S.W.   +128 more
core   +1 more source

Assembly, trafficking and function of gamma-secretase [PDF]

, 2006
gamma-Secretase catalyzes the final cleavage of the beta-amyloid precursor protein to generate amyloid-beta peptide, the principal component of amyloid plaques in the brains of patients suffering from Alzheimer's disease.
Haass, Christian, Steiner, Harald, Kaether, Christoph   +2 more
core   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes [PDF]

, 2014
Aims/hypothesis: Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP ...
Hamilton, D. Lee, Montagut , Gemma, Meakin, Paul J., Susan M. Jalicy, Meakin, PJ, D. Lee Hamilton, Dawn Bestow, Bestow, D, Hamilton, DL, Montagut, G, Michael L. J. Ashford, Jalicy, Susan M., Findlay, John A., Jalicy, SM, Ashford, MLJ, Ashford, Michael L. J.; id_orcid, Montagut, Gemma, John A. Findlay, Gemma Montagut, Meakin, Paul J, Ashford, Michael L J, Bestow, Dawn, Findlay, John A, Jalicy, Susan M, Hamilton, David Lee, Findlay, JA, Paul J. Meakin   +26 more
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Regulation of Mint1-dependent APP trafficking by N1-Src [PDF]

, 2012
Alzheimer’s disease (AD) is a neurodegenerative disease characterised by the accumulation of Amyloid-beta (Aβ) plaques and neurofibrillary tangles. Aβ plaques form as a result of improper trafficking and processing of the Amyloid precursor protein (APP).
Black, Hannah Lucy
core