Results 151 to 160 of about 249,317 (377)

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. [PDF]

, 1993
D. E. Schmechel, Ann M. Saunders, Warren J. Strittmatter, Barbara J. Crain, Christine M. Hulette, Sun Hyung Joo, Margaret A. Pericak‐Vance, Dmitry Goldgaber, Allen D. Roses   +8 more
openalex   +1 more source

Protease‐Mediated Synthesis of Zein Nanofibrils: From Structural Elucidation to Functional Application

Advanced Science, EarlyView.
The globular shape and hydrophobicity of zein made it unsuitable to be processed in pure aqueous environment. Pepsin‐mediated hydrolysis converts zein into water‐soluble and fibril‐forming peptides with a bioconversion rate exceeding 70%, enabling the self‐assembly of amyloid‐like nanofibrils.
Mingqin Li, Tonghui Jin, Simone Wüthrich, Jiangtao Zhou, Qiyao Sun, Ting Li, Zhou Dong, Eva Maria Zunzuneigui Bru, Raffaele Mezzenga   +8 more
wiley   +1 more source

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. [PDF]

, 1994
Jan Näslund, Angelika Schierhorn, Ulf Hellman, Lars Lannfelt, A.D. Roses, Lars O. Tjernberg, Jerzy Silberring, Sam Gandy, Bengt Winblad, Paul Greengard   +9 more
openalex   +1 more source

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, EarlyView.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source

Thermodynamic Description of Beta Amyloid Formation [PDF]

arXiv, 2013
Protein function depends on both protein structure and amino acid (aa) sequence. Here we show that modular features of both structure and function can be quantified from the aa sequences alone for the small (40,42 aa) plaque-forming amyloid beta fragments. Some edge and center features of the fragments are predicted. Contrasting results from the second
arxiv  

Human antibodies reactive with beta-amyloid protein in Alzheimer's disease. [PDF]

, 1993
Felicia Gaskin, J Finley, Qiang Fang, S. Xu, Shu Man Fu   +4 more
openalex   +1 more source

Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization

Advanced Science, EarlyView.
Occlusion of tumor blood vessels represents a promising yet challenging approach in cancer treatment. Herein, supramolecularly engineered platelets conjugated with morphology‐transformable nanoparticles is developed for precise tumor embolization. The engineered platelets actively accumulate at tumor sites following induced blood vessel injury.
Junyan Li, Ziyi Wang, Ruifeng Luo, Xingping Quan, Hong U Fong, Qian Cheng, Jianwen Wei, Leo Wang, Yonghua Zhao, Ruibing Wang   +9 more
wiley   +1 more source

Quantum Resources Required for Binding Affinity Calculations of Amyloid beta [PDF]

arXiv
Amyloid beta, an intrinsically disordered protein, plays a seemingly important but not well-understood role in neurodegenerative diseases like Alzheimer's disease. A key feature of amyloid beta, which could lead to potential therapeutic intervention pathways, is its binding affinity to certain metal centers, like iron and copper.
arxiv  

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
wiley   +1 more source

PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects

BioFactors, Volume 48, Issue 6, Page 1226-1249, November/December 2022., 2022
Abstract Ocular allergies are becoming more prevalent as more airborne pollutants, irritants and microbes pervade our environment. Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects >40% of the world's human population on a ...
Najam A. Sharif
wiley   +1 more source