Results 161 to 170 of about 249,317 (377)
Journal of Integrative Neuroscience, 2019 Regulation of neuroinflammation is critical to control the detrimental impact of chronic stress in the central nervous system. Neuroinflammation occurs in response to chronic stress, leading to enhanced neuronal damage in the brain.
Yangyang Hou +7 more
doaj +1 more source
Advanced Science, EarlyView.An open‐source, low‐cost 3D perfusion system integrating bioprinted scaffolds and live‐imaging overcomes 2D culture limitations. Modeling the cerebrospinal fluid‐filled subarachnoid space, it reveals flow‐dependent focal adhesion kinase activation in meningothelial cells, demonstrating a powerful platform for studying mechanobiology and creating ...
Subashree Srinivasan +7 more
wiley +1 more source
Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Background Audiovisual stimulation, such as auditory stimulation, light stimulation, and audiovisual combined stimulation, as a non‐invasive stimulation, which can induce gamma oscillation, has received increased attention in recent years, and it has been preliminarily applied in the clinical rehabilitation of brain dysfunctions, such as ...
Xixi Chen +6 more
wiley +1 more source
Unraveling Alzheimer’s: the promise of aducanumab, lecanemab, and donanemab
The Egyptian Journal of Neurology, Psychiatry and NeurosurgeryAlzheimer’s disease (AD) is a neurodegenerative condition that causes cognitive decline, memory loss, and reduced personal autonomy. The pathology of AD involves the aggregation of abnormal brain proteins, specifically beta-amyloid plaques and tau ...
Taha Basit Ameen +5 more
doaj +1 more source
Advanced Science, EarlyView.Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan +6 more
wiley +1 more source
Heliyon, 2020 Alzheimer's disease is a progressive neurodegenerative disorder. In this disease neurodegeneration occurs due to deposition of aggregated amyloid-beta plaques and neurofibrillary tangles (hyperphosphorylated tau proteins).
Rupali Kumari +2 more
doaj
Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease
Advanced Science, EarlyView.This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang +10 more
wiley +1 more source
Optimal Control For Anti-Abeta Treatment in Alzheimer's Disease using a Reaction-Diffusion Model [PDF]
arXivAlzheimer's disease is a progressive neurodegenerative disorder that significantly impairs patient survival and quality of life. While current pharmacological treatments aim to slow disease progression, they remain insufficient in halting cognitive decline.
arxiv
Advanced Science, EarlyView.Polyglutamine (polyQ) tract expansion (≥ 36 amino acids) within the N‐terminal region of the Huntingtin protein (Httex1) causes Huntington's disease (HD), for which the underlying causes are not well‐understood. The authors performed computer simulations to understand the cause of HD at the molecular level.
Priyesh Mohanty +2 more
wiley +1 more source