Contrast Agent Clearance Dynamics and Diffusion in the Mouse Brain After Ventricular Administration
Advanced Science, EarlyView.Schematic representation of contrast agent clearance by convective bulk flow from the ventricular spaces to the subarachnoid space on the ventral aspect of the brain, or by diffusion into the parenchyma across the pia‐glia or through the semi‐permeable ependyma. Abstract Fluid and solute exchange between cerebrospinal fluid (CSF) spaces and the central
Yann Decker +2 more
wiley +1 more source
Advanced Science, EarlyView.Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim +6 more
wiley +1 more source
Fabrication and Functionalisation of Nanocarbon‐Based Field‐Effect Transistor Biosensors
ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022 Next‐generation diagnostics: Nanocarbon‐based field effect transistors (NC‐FETs) use incoming target analytes to impart a gating effect on conductance. Here, we review the operational mechanisms behind NC‐FETs, the fabrication and functionalisation of NC‐FETs with receptor biomolecules and downstream biosensing applications.
Chang‐Seuk Lee +4 more
wiley +1 more source
Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. [PDF]
, 1991 Mark J. Adler +4 more
openalex +1 more source
Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022 A tritiated tetrazine based on a phenyl/pyridyl core structure was successfully radiolabeled with NaBT4 by reducing an aldehyde moiety. The synthon was effectively employed to label an antibody in vitro with pretargeted autoradiography. Abstract Tetrazine (Tz)–trans‐cyclooctene (TCO) ligation is an ultra‐fast and highly selective reaction and it is ...
Natasha Shalina Radjani Bidesi +9 more
wiley +1 more source
Melatonin-mediated calcineurin inactivation attenuates amyloid beta-induced apoptosis
IBRO Neuroscience ReportsAlzheimer’s disease (AD) is the most common age-related progressive neurodegenerative disorder. The accumulation of amyloid beta-peptide is a neuropathological marker of AD.
Jeong-Min Hong +4 more
doaj
Brain amyloid β protein and memory disruption in Alzheimer’s disease
Neuropsychiatric Disease and Treatment, 2010 Weiming XiaCenter for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAAbstract: The development of amyloid-containing neuritic plaques is an invariable characteristic of ...
Weiming Xia
doaj
Interaction between U-shaped amyloid beta fibril and semiconducting silicon nitride monolayer [PDF]
arXivMotivated by some recent works showing the ability of semiconducting monolayers to disintegrate the structures of biological fibrils, we have applied molecular dynamics (MD) simulations in both classical and quantum regimes to investigate whether semiconducting Si$_3$N$_4$ monolayer has the same ability on interaction with U-shaped amyloid beta (A ...
arxiv
Peptoid morphology studies and its performance in inhibiting islet amyloid polypeptide [PDF]
, 2016 1 Proteins have various arrays of functions in human bodies. The bio-functions of proteins are depend on their amino acid sequences and folding processes that affect protein structure.
Park, Dongwon
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