Results 201 to 210 of about 376,147 (348)

Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer's Disease and HIV-Associated Neurocognitive Disorders. [PDF]

Int J Mol Sci
Njoku GC, Kanmogne GD.
europepmc   +1 more source

Targeted Magnetic Nanoparticles for Beta-Amyloid Detection

Nelly S. Chmelyuk, А. А. Никитин, Veronika Vadekhina, Vladimir A. Mitkevich, Maxim A. Abakumov   +4 more
openalex   +1 more source

Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease

, 2013
S Wuwongse, Sally Shuk-Yee Cheng, Ginger Tsz-Hin Wong, Clara Hiu-Ling Hung, Natalie Qishan Zhang, Yuen‐Shan Ho, Andrew Chi-Kin Law, Raymond Chuen‐Chung Chang   +7 more
openalex   +2 more sources

Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice

, 2020
CarolineBrandão Quines, Simone Pinton, MariaEduarda Ziani Gutierrez, AnneSuély Pinto Savall, Edina da Luz Abreu, Kelly Ayumi Nakama, Renata Bem dos Santos, MarinaCosta Monteiro Guedes, Daiana Silva Ávila, Cristiane Luchese, Sandra Elisa Haas   +10 more
openalex   +1 more source

Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation

Annals of Neurology, EarlyView.
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko, Gargi Banerjee, Dermot Mallon, Kitti Thiankhaw, Rupert Oliver, Victoria Harvey, Gareth Ambler, Michael Zandi, Hans Rolf Jäger, David J. Werring   +9 more
wiley   +1 more source

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Angewandte Chemie, EarlyView.
The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng, Belén Lucas, Philipp Lampe, Stefano Ugel, Suyuan Chen, Anke Unger, Matthias Bischoff, Soheila Rezaei Adariani, Kesava Reddy Naredla, Kamal Kumar, Annika Schmidt, Carsten Strohmann, Petra Janning, Raphael Gasper, María Lucas, Malte Gersch, Sonja Sievers, Vincenzo Bronte, Slava Ziegler, Herbert Waldmann   +19 more
wiley   +2 more sources

Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease. [PDF]

Alzheimers Dement
Mangalmurti A, Zengeler KE, Hollis A, Golden E, Riddlemoser G, Lukens JR.   +5 more
europepmc   +1 more source

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis [PDF]

, 2009
Sakeneh Zraika, Rebecca L. Hull, Jayalakshmi Udayasankar, Kathryn Aston‐Mourney, Shoba Subramanian, Robert Kisilevsky, Walter A. Szarek, Steven E. Kahn   +7 more
openalex   +1 more source

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, EarlyView.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

Water Networks as Hydrophobic Recognition Motifs in Proteins

Angewandte Chemie, EarlyView.
Hydrophobic groups can strengthen confined water networks, promoting order that propagates through the protein structure and drives recognition, creating a paradoxical hydrophobic binding hot spot. Polar groups are rejected because they disrupt the network, destabilizing the protein structure.
Serena G. Piticchio, Miriam Martínez‐Cartró, Salvatore Scaffidi, Sergio Rodríguez‐Arévalo, Andrea Bagán, Ainoa Sánchez‐Arfelis, Sarah Picaud, Tobias Krojer, Panagis Filippakopoulos, Frank von Delft, Carmen Escolano, Carles Galdeano, Xavier Barril   +12 more
wiley   +2 more sources