Results 81 to 90 of about 376,147 (348)
Heliyon, 2020 Alzheimer's disease is a progressive neurodegenerative disorder. In this disease neurodegeneration occurs due to deposition of aggregated amyloid-beta plaques and neurofibrillary tangles (hyperphosphorylated tau proteins).
Rupali Kumari +2 more
doaj +1 more source
Looking for a generic inhibitor of amyloid-like fibril formation among flavone derivatives [PDF]
PeerJ, 2015 A range of diseases is associated with amyloid fibril formation. Despite different proteins being responsible for each disease, all of them share similar features including beta-sheet-rich secondary structure and fibril-like protein aggregates.
Tomas Šneideris +5 more
doaj +2 more sources
The effects of peripheral and central high insulin on brain insulin signaling and amyloid-β in young and old APP/PS1 mice [PDF]
, 2016 Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships ...
Caesar, Emily E +9 more
core +2 more sources
Advanced Functional Materials, EarlyView.Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird +8 more
wiley +1 more source
Scientific Reports, 2017 Osmotin is a pathogenesis-related plant protein, have gained focus of research because of its homology with mammalian adiponectin. The therapeutic properties of osmotin have been explored in recent years as it exhibits neuroprotective effects against ...
Noman Bin Abid +2 more
doaj +1 more source
A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory [PDF]
, 2008 Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley +5 more
core +1 more source
Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]
, 2010 Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Ahsen, Nico von +7 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel +6 more
wiley +1 more source
Alzheimer’s disease-associated peptide Aβ42 mobilizes ER Ca2+ via InsP3R-dependent and -independent mechanisms [PDF]
, 2013 Dysregulation of Ca2+ homeostasis is considered to contribute to the toxic action of the Alzheimer’s Disease (AD) associated Amyloid β-peptide (Aβ). Ca2+ fluxes across the plasma membrane and release from intracellular stores have both been reported to ...
Amijee, Hozeefa +5 more
core +3 more sources
Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials
Advanced Healthcare Materials, EarlyView.The production of recombinant proteins represents a fundamental step in the characterisation of marine invertebrate adhesives and in the development of bio‐inspired glues. The association of these proteins with other components such as ions, proteins, polysaccharides, or polymers enables the fabrication of biomaterials for various healthcare ...
Alessandra Whaite +4 more
wiley +1 more source