Results 21 to 30 of about 15,436 (169)

Transthyretin amyloid cardiomyopathy: Treatment pipeline, clinical trials, and challenges

Journal of Public Health and Primary Care, 2021
Transthyretin amyloid cardiomyopathy (ATTR-CM) is potentially a fatal disease characterized by abnormal buildup of amyloid fibrils primarily in the heart causing progressive heart failure. It is categorized into two subtypes-hereditary ATTR and wild type
Sweety Sharma, Bhawna Sharma
doaj   +1 more source

A review of transthyretin cardiac amyloidosis

Romanian Journal of Internal Medicine, 2023
Transthyretin cardiac amyloidosis is a progressive disease known to cause heart failure, conduction anomalies, and arrythmias. Due to poor outcomes and mortality from severe cardiomyopathy, prevalence and incident rates are often underreported. As global
Jhawar Nikita, Moreno Juan Carlos Leoni, Chirila Razvan   +2 more
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Ser77Tyr transthyretin amyloidosis in Israel: Initial manifestations and diagnostic features

Annals of Clinical and Translational Neurology, 2023
Objective Amyloidosis due to the transthyretin Ser77Tyr mutation (ATTRS77Y) is a rare autosomal‐dominant disorder, characterized by carpal‐tunnel syndrome, poly‐ and autonomic‐neuropathy, and cardiomyopathy.
Amir Dori, Michael Arad, Yishay Wasserstrum, Arthur Pollak, Vera Nikitin, Merav Ben‐David, Jana Shamash, Ayelet Hashachar Nahum, Efrat Shavit‐Stein, Liran Domachevsky, Rafael Kuperstein, Dan Dominissini, Natalia Shelestovich, Menachem Sadeh, Elon Pras, Lior Greenbaum   +15 more
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Step‐by‐step typing for the accurate diagnosis of concurrent light chain and transthyretin cardiac amyloidosis

ESC Heart Failure, 2022
While 99mTc‐pyrophosphate scintigraphy is clearly useful in diagnosing transthyretin amyloid cardiomyopathy (ATTR‐CM), it is necessary to know the pitfalls of this test for proper use. We present a rare case of concurrent ATTR‐CM and amyloid light chain (
Hidenori Moriyama, Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Motoaki Sano, Masayoshi Tasaki, Shunta Sakai, Mitsuharu Ueda, Keiichi Fukuda   +8 more
doaj   +1 more source

Left ventricular active strain energy density is a promising new measure of systolic function

Scientific Reports, 2022
The left ventricular ejection fraction does not accurately predict exercise capacity or symptom severity and has a limited role in predicting prognosis in heart failure.
David H. MacIver, Peter Agger, Jonathan C. L. Rodrigues, Henggui Zhang   +3 more
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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain‐mediated cardiotoxicity

EMBO Molecular Medicine, 2014
AL amyloidosis is the consequence of clonal production of amyloidogenic immunoglobulin light chain (LC) proteins, often resulting in a rapidly progressive and fatal amyloid cardiomyopathy.
Jian Guan, Shikha Mishra, Yiling Qiu, Jianru Shi, Kyle Trudeau, Guy Las, Marc Liesa, Orian S Shirihai, Lawreen H Connors, David C Seldin, Rodney H Falk, Calum A MacRae, Ronglih Liao   +12 more
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AMYLOID CARDIOMYOPATHY: DIAGNOSIS AND TREATMENT

Байкальский медицинский журнал, 2023
The review presents current data on heart disease in systemic amyloidosis. The article discusses variants of amyloi-dosis with common heart disease: AL-, ATTRwt- and ATTRv amyloidoses.
Elena S Eniseeva
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A classic case of amyloid cardiomyopathy [PDF]

BMJ Case Reports, 2012
A 55-year-old-woman with a history of hypertension, dyslipidemia and carpal tunnel syndrome had slowly progressive fatigue, weight loss, early satiety and diarrhoea over a 12-month period. She then developed several syncopal episodes attributed to orthostatic hypotension and one episode of cardiorespiratory arrest secondary to ventricular tachycardia ...
Hayan, Jouni, William G, Morice, S Vincent, Rajkumar, Joerg, Herrmann   +3 more
openaire   +2 more sources

Systemic embolism in amyloid transthyretin cardiomyopathy

European Journal of Heart Failure, 2022
Aims Although systemic embolism is a potential complication in transthyretin amyloid cardiomyopathy (ATTR‐CM), data about its incidence and prevalence are scarce. We studied the incidence, prevalence and factors associated with embolic events in ATTR‐CM.
Vilches, Silvia, Fontana, Marianna, Gonzalez‐Lopez, Esther, Mitrani, Lindsey, Saturi, Giulia, Renju, Mary, Griffin, Jan M., Caponetti, Angelo, Gnanasampanthan, Sahana, De los Santos, Jeffeny, Gagliardi, Christian, Rivas, Adrian, Dominguez, Fernando, Longhi, Simone, Rapezzi, Claudio, Maurer, Mathew S., Gillmore, Julian, Garcia‐Pavia, Pablo   +17 more
openaire   +9 more sources

Wild-Type Transthyretin Cardiac Amyloidosis in a Transplanted Heart

JACC: Case Reports, 2023
Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is more prevalent than appreciated in the elderly. We present the case of an 88-year-old woman who underwent heart transplantation for ischemic cardiomyopathy and then presented 21 years later ...
Lily K. Stern, MD, Pamela A. Ivey, MD, Corey J. Lum, DO, Shayaan Zaidi, Daniel Luthringer, MD, Angela Velleca, BSN, CCTC, Jon A. Kobashigawa, MD, Jignesh K. Patel, MD, PhD, Michelle M. Kittleson, MD, PhD   +8 more
doaj   +1 more source