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Amyloid Oligomers, Protofibrils and Fibrils
2019Amyloid diseases are of major concern all over the world due to a number of factors including: (i) aging population, (ii) increasing life span and (iii) lack of effective pharmacotherapy options. The past decade has seen intense research in discovering disease-modifying multi-targeting small molecules as therapeutic options.
Mohammad Khursheed, Siddiqi +4 more
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Mesoscopic Properties of Semiflexible Amyloid Fibrils
Langmuir, 2004We have determined the contour length, persistence length, bending rigidity, and critical percolation concentration for semiflexible amyloid fibrils formed from the globular proteins beta-lactoglobulin, bovine serum albumin, and ovalbumin. The persistence length was estimated using an adjusted random contact model for highly charged semiflexible chains.
Sagis, L.M.C. +2 more
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Inhibitors of amyloid fibril formation
Many diseases are caused by misfolded and denatured proteins, leading to neurodegenerative diseases. In recent decades researchers have developed a variety of compounds, including polymeric inhibitors and natural compounds, antibodies, and chaperones, to inhibit protein aggregation, decrease the toxic effects of amyloid fibrils, and facilitate ...Elaheh, Tavili +2 more
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Biotechnological applications of amyloid fibrils
Protein aggregates and amyloid fibrils have special qualities and are used in a variety of biotechnological applications. They are extensively employed in bioremediation, biomaterials, and biocatalysis. Because of their capacity to encapsulate and release pharmaceuticals and their sensitivity to certain molecules, respectively, they are also used in ...Mohsen, Nabi Afjadi +3 more
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Amyloid Neuropathy: Relationship between Amyloid Fibrils and Macrophages
Ultrastructural Pathology, 1984A case of amyloid neuropathy associated with a multiple myeloma IgG light chain is reported. Under light microscopy the peripheral nerve exhibited several amyloid deposits. Electron microscopy revealed numerous amyloid deposits; at their periphery, macrophagic histiocytes were observed, containing a few tufts of parallel fibrils in their cytoplasm.
A, Vital, C, Vital
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Self-Assembly of Ovalbumin into Amyloid and Non-Amyloid Fibrils
Biomacromolecules, 2012We study the fibrillation pathway of ovalbumin protein and report the simultaneous formation of several types of fibrils, with clear structural and physical differences. We compare the fibrillation mechanisms at low pH with and without salt, and follow the kinetics of fibrils growth by atomic force microscopy (AFM), static and dynamic light scattering (
Lara C +4 more
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Amyloid Fibrils in Bionanotechnology
Australian Journal of Chemistry, 2004An amyloid fibril is a highly ordered, insoluble form of protein that results when a normally soluble protein aggregates via a self-association process to form a structured nanotube. Such fibrils can now be routinely generated from purified proteins in the laboratory, and have attracted burgeoning interest due to their role in a variety of disease ...
Sarah H. Waterhouse, Juliet A. Gerrard
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Structural Evolution of Fibril Polymorphs During Amyloid Assembly
Cell, 2023Martin Wilkinson +2 more
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Amyloid Fibrils Aerogel for Sustainable Removal of Organic Contaminants From Water
Advanced Materials, 2020Laura Nyström +2 more
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IMMUNOGLOBULIN AND AMYLOID FIBRIL PROTEINS
British Journal of Haematology, 1973openaire +2 more sources