Results 1 to 10 of about 252,333 (374)
Amyloid precursor protein and mitochondria. [PDF]
Curr Opin Neurobiol, 2023 Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD.
Strope TA, Wilkins HM.
europepmc +4 more sources
The amyloid precursor protein: beyond amyloid
Molecular Neurodegeneration, 2006 The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and ...
Zheng Hui, Koo Edward H
doaj +4 more sources
Amyloid Precursor Protein and Alzheimer's Disease. [PDF]
Int J Mol Sci, 2023 Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau ...
Orobets KS, Karamyshev AL.
europepmc +3 more sources
Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
Oncotarget, 2016 Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species.
P. Pandey +11 more
semanticscholar +4 more sources
Biology and pathophysiology of the amyloid precursor protein [PDF]
Molecular Neurodegeneration, 2011 The amyloid precursor protein (APP) plays a central role in the pathophysiology of Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in the generation of β-amyloid peptides (Aβ).
Koo Edward H, Zheng Hui
doaj +6 more sources
Amyloid precursor protein processing and bioenergetics [PDF]
Brain Research Bulletin, 2017 The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing
Heather M. Wilkins, R. Swerdlow
semanticscholar +4 more sources
Amyloid precursor protein and neural development [PDF]
Development, 2014 Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this ...
Maya Nicolas, Bassem A. Hassan
semanticscholar +4 more sources
Secretases Related to Amyloid Precursor Protein Processing [PDF]
Membranes, 2021 Alzheimer’s disease (AD) is a common neurodegenerative disease whose prevalence increases with age. An increasing number of findings suggest that abnormalities in the metabolism of amyloid precursor protein (APP), a single transmembrane aspartic protein ...
Xiaoling Liu, Yan Liu, Shangrong Ji
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The Amyloid Precursor Protein Controls PIKfyve Function. [PDF]
PLoS ONE, 2015 While the Amyloid Precursor Protein (APP) plays a central role in Alzheimer's disease, its cellular function still remains largely unclear. It was our goal to establish APP function which will provide insights into APP's implication in Alzheimer's ...
Zita Balklava +7 more
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Amyloid Precursor Protein (APP) and GABAergic Neurotransmission [PDF]
Cells, 2019 The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ) peptides, key etiological agents of Alzheimer’s disease (AD), are generated by sequential proteolytic processing involving β- and γ-secretases.
Bor Luen Tang
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