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Amyloid Precursor Protein and Alzheimer's Disease. [PDF]
Int J Mol Sci, 2023 Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall.
Orobets KS, Karamyshev AL.
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The amyloid precursor protein: beyond amyloid
Molecular Neurodegeneration, 2006 The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and ...
Zheng Hui, Koo Edward H
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Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice [PDF]
Neurobiology of Disease, 2005 Even though the idea that amyloid β peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this ...
Elena M. Ribé +18 more
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Herpes simplex virus interferes with amyloid precursor protein processing [PDF]
, 2005 Background The early events underlying Alzheimer's disease (AD) remain uncertain, although environmental factors may be involved. Work in this laboratory has shown that the combination of herpes simplex virus type 1 (HSV1) in brain and carriage of the
Suzanne J. Shipley +3 more
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Negative interplay between HIV-1 Gag and amyloid precursor protein centers around competition for VPS4A and TSG101. [PDF]
Proc Natl Acad Sci U S AGu F, Naghavi MH.
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Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease. [PDF]
Aging Dis, 2023 Chen J +6 more
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PLoS ONE, 2022 The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer's disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and γ ...
Edward T Parkin +3 more
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Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
International Journal of Molecular Sciences, 2021 Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals.
Han Na Lee, M. Jeong, S. Jang
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Altered processing of amyloid precursor protein in cells undergoing apoptosis. [PDF]
PLoS ONE, 2013 Altered proteolysis of amyloid precursor protein is an important determinant of pathology development in Alzheimer's disease. Here, we describe the detection of two novel fragments of amyloid precursor protein in H4 neuroglioma cells undergoing apoptosis.
Tina Fiorelli +2 more
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Secretases Related to Amyloid Precursor Protein Processing
Membranes, 2021 Alzheimer’s disease (AD) is a common neurodegenerative disease whose prevalence increases with age. An increasing number of findings suggest that abnormalities in the metabolism of amyloid precursor protein (APP), a single transmembrane aspartic protein ...
Xiaoling Liu, Yan Liu, Shangrong Ji
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