Results 161 to 170 of about 343,599 (390)

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.

, 1996
P. J. Tienari, Bart De Strooper, Elina Ikonen, Mikael Simons, Andreas Weidemann, Christian Czech, Tobias Hartmann, N Ida, Gerd Multhaup, Colin L. Masters, F. Van Leuven, Konrad Beyreuther, Carlos G. Dotti   +12 more
openalex   +2 more sources

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein [PDF]

, 2018
Jessica E. Young, Lauren Fong, Harald Frankowski, Gregory A. Petsko, Scott A. Small, Lawrence S.B. Goldstein   +5 more
openalex   +1 more source

Recognition of the amyloid precursor protein by human γ-secretase

Science, 2019
R. Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, J. Lei, Yigong Shi   +5 more
semanticscholar   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

MOESM3 of Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention

, 2016
Cansu Agca, Diana Klakotskaia, Todd R. Schachtman, Anthony W.S. Chan, James J. Lah, Yüksel Ağca   +5 more
openalex   +1 more source

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment [PDF]

, 2010
Carrie McAllister, Jiangang Long, Adrienne Bowers, Aaron Walker, Philip Cao, Shin-Ichiro Honda, Nobuhiro Harada, Matthias Staufenbiel, Yong Shen, Rena Li   +9 more
openalex   +1 more source

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Influence of apolipoprotein E and its receptors on cere-bral amyloid precursor protein metabolism following

Chinese Journal of Traumatology, 2012
【Abstract】Traumatic brain injury (TBI) is the lead-ing cause of mortality and disability among young indi-viduals in our society, and globally the incidence of TBI is rising sharply. Mounting evidence has indicated that apolipoprotein E (apoE: protein;
ZHOU Shuai, SUN Xiao-chuan
doaj  

Ex-vivo analysis platforms for amyloid precursor protein cleavage

, 2021
Yuji Kamikubo, Hao Jin, Kazue Niisato, Yoshie Hashimoto, Nobumasa Takasugi, Takashi Sakurai   +5 more
openalex   +1 more source