Results 181 to 190 of about 343,599 (390)

Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway [PDF]

, 2000
José Luis Galbete, T. Rodriguez Martin, Elisa PERESSINI, Piergiorgio MODENA, Roberto Bianchi, Gianluigi Forloni   +5 more
openalex   +1 more source

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani, Fei Fang, Scott E. Counts, Liangliang Sun   +3 more
wiley   +1 more source

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease

, 2017
Zhongcan Chen, Wei Zhang, Lingling Chua, Chou Chai, Rong Li, Lin Lin, Zhen Cao, Dario C. Angeles, Lawrence W. Stanton, Jianhe Peng, Zhidong Zhou, Kah‐Leong Lim, Li Zeng, Eng‐King Tan   +13 more
openalex   +2 more sources

Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons

Cellular and Molecular Life Sciences, 2018
Karine Laulagnier, Charlotte Javalet, Fiona J. Hemming, M. Chivet, G. Lachenal, Béatrice Blot, C. Chatellard, R. Sadoul   +7 more
semanticscholar   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

, 2013
Kevin W. Hunt, Adam W. Cook, Ryan J. Watts, Christopher T. Clark, Guy Vigers, Darin Smith, Andrew T. Metcalf, Indrani W. Gunawardana, Michael Burkard, April Cox, Mary Geck, Darrin Dutcher, Allen A. Thomas, Sumeet Rana, Nicholas C. Kallan, Robert Kirk DeLisle, James P. Rizzi, Kelly Regal, Douglas M. Sammond, Robert D. Groneberg, Michael Siu, Hans E. Purkey, Joseph P. Lyssikatos, Allison Marlow, Xingrong Liu, Tony P. Tang   +25 more
openalex   +1 more source

c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK [PDF]

, 2001
Shuji Matsuda, Takashi Yasukawa, Yasuko Homma, Yuko Ito, Takako Niikura, Takako Hiraki, Shuichi Hirai, Shigeo Ohno, Yoshiko Kita, Masaoki Kawasumi, Keisuke Kouyama, Tokuo Yamamoto, John Kyriakis, Ikuo Nishimoto   +13 more
openalex   +1 more source

Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease.

Cold Spring Harbor Perspectives in Medicine, 2017
J. Tcw, A. Goate
semanticscholar   +1 more source

New Hybrid Nanocomposite Films for Optical Diagnostics and Optical Temperature Sensing: Synergy Among α‐Synuclein, Gold and Upconverting Nanoparticles

Small, EarlyView.
Gold and upconverting nanoparticles coated with alpha‐synuclein were exploited to produce a quasi‐monolayer hybrid film. The film was then characterized, and its behaviour as a primary optical nano‐thermometer was studied. The film was also used in a proof‐of‐concept study of image‐based optical nanothermometry exploiting a home‐built up‐conversion ...
Emil Milan, Roberto Tira, Chiara Cressoni, Federico Antonio Giacomazzi, Patrizia Canton, Michael Assfalg, Adolfo Speghini   +6 more
wiley   +1 more source