Results 191 to 200 of about 3,811,291 (280)

The silent consequence of overdose: The case for brain injury‐informed opioid treatment

Addiction, EarlyView.
Nathaniel Day, Kym Kaufmann, Mauricio Garcia‐Barrera, Jitender Sareen, Daniel Vigo   +4 more
wiley   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling, Lena Marth, Katja Sandkühler, Anna Stockbauer, Elisabeth Wlasich, Alexander Jäck, Olivia Wagemann, Julia Kustermann, Steffen Halbgebauer, Hayrettin Tumani, Günter Höglinger, Johannes Levin   +11 more
wiley   +1 more source

RABGAP1 is a sensor that facilitates the sorting and processing of amyloid precursor protein. [PDF]

EMBO J
Eden J, Kaufman JGG, Pereira C, Fox E, Cattin-Ortolá J, Benedetti L, Nieuwenhuis B, Owen DJ, Lippincott-Schwartz J, Munro S, Gershlick DC.   +10 more
europepmc   +1 more source

Down Syndrome and Alzheimer's Disease: A Qualitative Study Exploring Understanding and Perceptions of Dementia and Diagnostic Pathways Among People With Down Syndrome and Their Families

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background People with Down syndrome are at high risk of Alzheimer's disease. Dementia diagnosis and support are a growing challenge for health and social care systems. There is limited knowledge of the perceptions of dementia and dementia diagnostic pathways among people with Down syndrome and their families.
M. L. Healy, A. Brodtmann, A. M. Foster, D. Ayton   +3 more
wiley   +1 more source

Amyloid precursor protein accumulation in glioblastoma is associated with altered synaptic dynamics and immune suppression. [PDF]

Discov Oncol
Porter TR, Inyushin M, Kucheryavykh L.
europepmc   +1 more source

A validated deep learning workflow for 3D quantification of amyloid plaques in cleared mouse brain

Journal of Microscopy, EarlyView.
Abstract Accurate quantification of amyloid plaque pathology is essential for understanding Alzheimer's disease (AD) progression and evaluating therapeutic interventions. Yet, conventional histology relies on sampling thin tissue sections and therefore incompletely captures three‐dimensional (3D) plaque distributions, introducing bias and limiting ...
Veronika Valova, Louise Cole, Neftali Flores Rodriguez, Filip Braet, Daniel M. Johnstone, Richard Harwood   +5 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source