Results 191 to 200 of about 175,143 (304)

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

EPR spectroscopy reveals different Cu(ii) coordination in APP_142-172 and APP_145-170 peptide fragments of amyloid precursor protein. [PDF]

RSC Adv
Xu L, Kuang J, Liu A, Liao L, Yu L, Tian C.   +5 more
europepmc   +1 more source

Amyloid precursor protein (APP); β-amyloid (Aβ) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release. [PDF]

Proc Natl Acad Sci U S A
Zhao R, Sophanpanichkul P, Chadarevian JP, Ding Y, Dai H, Nayak M, Davtyan H, Blurton-Jones M, Goldstein SAN.   +8 more
europepmc   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Expression and function of β-site amyloid precursor protein-cleaving enzyme 2 in vascular endothelium. [PDF]

Am J Physiol Heart Circ Physiol
d'Uscio LV, Kovalenko T, He T, Christensen TA, Salisbury JL, Katusic ZS.   +5 more
europepmc   +1 more source

MXene‐Enabled Wearable Biosensors: A Design Framework for Autonomous Biosensing

ChemElectroChem, Volume 13, Issue 9, 5 May 2026.
Bridging nanoscale innovation with MXene to real‐time, patient‐centered health systems. MXenes, a rapidly expanding family of two‐dimensional transition metal carbides and nitrides, have emerged as leading materials for wearable bioelectronics due to their metallic conductivity, termination‐rich surfaces, mechanical compliance, and tunable interlayer ...
Jegan Rajendran, Gymama Slaughter
wiley   +1 more source

Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice. [PDF]

J Neurochem
Nagai-Arakawa I, Muramatsu I, Uwada J, Tsuda Y, Tokunaga A, Irie A, Maeda H, Madokoro Y, Sato T, Uchida Y, Saito T, Saido TC, Sada K, Masuoka T, Matsukawa N.   +14 more
europepmc   +1 more source