Results 211 to 220 of about 3,811,291 (280)

Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release. [PDF]

Proc Natl Acad Sci U S A
Zhao R, Sophanpanichkul P, Chadarevian JP, Ding Y, Dai H, Nayak M, Davtyan H, Blurton-Jones M, Goldstein SAN.   +8 more
europepmc   +1 more source

Oral health and systemic health outcomes: A call for interdisciplinary action

Periodontology 2000, EarlyView.
Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European Federation of Periodontology (EFP) and the European Association of Dental ...
Moritz Kebschull, Ryan T. Demmer, Nigel Pitts, Huda Yusuf, Gitana Rederiene, Nikolaos Donos, Wim Teughels, Raman Bedi, Orsolya Nemeth, Mia Rakic, Stéphanie Tubert‐Jeannin, Raimondo Ascione, Francesco D'Aiuto, James Deschner, Thomas Dietrich, Mili Doshi, Julian Fisher, Ramón Juanatey, Phoebus Madianos, Katalin Nagy, Barry Quinn, Saulė Skinkytė, Lina Stangvaltaite‐Mouhat, Maria van den Muijsenbergh, Josep Vilaseca, Nicola West, Anton Sculean, Andreas Stavropoulos, Kenneth Eaton, Joint EFP/EADPH Working Group   +29 more
wiley   +1 more source

Iron-Mediated Overexpression of Amyloid Precursor Protein via Iron Responsive mRNA in Alzheimer's Disease. [PDF]

Int J Mol Sci
Khan MA.
europepmc   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

EPR spectroscopy reveals different Cu(ii) coordination in APP_142-172 and APP_145-170 peptide fragments of amyloid precursor protein. [PDF]

RSC Adv
Xu L, Kuang J, Liu A, Liao L, Yu L, Tian C.   +5 more
europepmc   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy. [PDF]

Genes Brain Behav
Dumont JR, Sheppard PAS, Fodor C, Coto MA, Yang S, Saito T, Saido TC, Rylett RJ, Prado MAM, Bussey TJ, Saksida LM, Prado VF.   +11 more
europepmc   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Iron responsive elements mRNA regulate Alzheimer's amyloid precursor protein translation through iron sensing. [PDF]

Front Aging Neurosci
Khan MA.
europepmc   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source