Results 231 to 240 of about 175,143 (304)

Alphafuser: a parsimonious approach to predicting higher‐order protein complexes

Acta Crystallographica Section D, Volume 82, Issue 5, Page 421-433, May 2026.
Alphafuser is a structure‐prediction pipeline that integrates experimental interaction data with AlphaFold‐based modeling to systematically assemble multiprotein complexes in a computationally efficient manner. By implementing an ipTM‐based pruning algorithm and validating against known structures and experimental assays, Alphafuser enables the ...
Audrey Guillotin, Stephanie Hutin, Lorelei Masselot-Joubert, Kamel Hammani, Chloe Zubieta, Max Nanao   +5 more
wiley   +1 more source

Brain derived neurotrophic factor and secreted amyloid precursor protein-α response to moderate and high intensity exercise. [PDF]

Physiol Rep
Spencer FSE, Elsworthy RJ, Breen L, Bishop JRB, Lucas SJE, Aldred S.   +5 more
europepmc   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Correction: Ramadan, W.S.; Alkarim, S. Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer's Model. Cells 2021, 10, 3511. [PDF]

Cells
Ramadan WS, Alkarim S.
europepmc   +1 more source

Transition From Land to Sea: Comparative Genomics Illuminates the Adaptive Evolution of the Intertidal Spider

Molecular Ecology Resources, Volume 26, Issue 4, May 2026.
ABSTRACT Spiders are renowned for their ecological versatility and silk‐based innovations in materials science, yet marine environments remain virtually uncolonized by this predominantly terrestrial lineage. A striking exception is the obligate intertidal spider genus Desis, whose members have evolved extraordinary physiological and behavioural ...
Fan Li, Yunyun Lv, Chao Bian, Quentin Moana Perrin, Yubo Zhang, Yixiao Wang, Lei Cao, Long Yu, Shengtao Guo, Wei Zhang, Qiong Shi, Daiqin Li   +11 more
wiley   +1 more source

Amyloid precursor protein promotes MASH progression by upregulating death receptor 6-mediated hepatocyte apoptosis. [PDF]

J Biol Chem
Guo Y, Huang H, Yang L, Shen Q, Liu Z, Wang Q, Chen S, Pan J, Zhai H, Li Y, Xu L, Yu C, Xu C.   +12 more
europepmc   +1 more source

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

Brain Pathology, Volume 36, Issue 3, May 2026.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García, Jorge Mena, Carol‐Ann Lao, David Adamuz, Laura Arnaldo, Cristina Carrato, Alex Menendez, Daniela Samaniego, Dolores Vilas, Lourdes Ispierto, Anna Planas, Ramiro Alvarez, Pau Pastor, Katrin Beyer   +13 more
wiley   +1 more source

Amyloid precursor protein as a fibrosis marker in infants with biliary atresia. [PDF]

Pediatr Res
Kamp JC, Madadi-Sanjani O, Uecker M, Werlein C, Neubert L, Kübler JF, Obed M, Junge N, Welte T, Ruwisch J, Jonigk DD, Stolk J, Vieten G, Janciauskiene S.   +13 more
europepmc   +1 more source

Hydroxytyrosol Mitigates Anxiety‐Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Hydroxytyrosol (HTyr), a phenolic compound of olive oil, exerts beneficial effects on several age‐related diseases. We previously demonstrated that oral HTyr administration in aging mice enhances hippocampal neurogenesis, known to play a role in memory formation and emotional behaviors. In the present study, we found that HTyr preferentially stimulates
Giorgio D'Andrea, Laura Bertini, Marco Costanzi, Fabiana Canini, Roberta Bernini, Andrea Fochetti, Mariangela Clemente, Silvia Proietti, Manuela Ceccarelli, Carla Caruso, Maurizia Caruso, Ferdinando Scavizzi, Marcello Raspa, Felice Tirone, Laura Micheli   +14 more
wiley   +1 more source