Results 241 to 250 of about 120,581 (311)

Amyloid precursor protein as a fibrosis marker in infants with biliary atresia. [PDF]

Pediatr Res
Kamp JC, Madadi-Sanjani O, Uecker M, Werlein C, Neubert L, Kübler JF, Obed M, Junge N, Welte T, Ruwisch J, Jonigk DD, Stolk J, Vieten G, Janciauskiene S.   +13 more
europepmc   +1 more source

Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL‐G‐F KI mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. METHODS An Alzheimer's pathogenesis by mutation in amyloid‐beta precursor protein gene (AppNL‐G‐F) knock‐in (KI) and HCNP precursor ...
Yo Tsuda, Yuta Madokoro, Kengo Suzuki, Takuya Ooba, Toyohiro Sato, Yuto Uchida, Itsumi Nagai‐Arakawa, Takashi Saito, Hideaki Hara, Hideki Hida, Noriyuki Matsukawa   +10 more
wiley   +1 more source

Amyloid precursor protein promotes MASH progression by upregulating death receptor 6-mediated hepatocyte apoptosis. [PDF]

J Biol Chem
Guo Y, Huang H, Yang L, Shen Q, Liu Z, Wang Q, Chen S, Pan J, Zhai H, Li Y, Xu L, Yu C, Xu C.   +12 more
europepmc   +1 more source

Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Adults with Down syndrome (DS) are at risk for Alzheimer's disease (AD), yet identifying the preclinical phase remains challenging. Intraindividual cognitive variability (IICV) may be a sensitive marker of early AD‐related changes but remains understudied in DS.
Luciana Mascarenhas Fonseca, Eardi Lila, Ali Shojaie, Jasmeer Chhatwal, Orestes Forlenza, Michal Schnaider Beeri, Sharon Krinsky‐McHale, Ann D. Cohen, Bradley T. Christian, Elizabeth Head, Mark Mapstone, Benjamin Handen, Beau M. Ances, Thomas Grabowski, Naomi S. Chaytor, Shahid Zaman, for the Alzheimer's Biomarkers Consortium‐ Down Syndrome (ABC‐DS) Investigators   +16 more
wiley   +1 more source

The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer's disease. [PDF]

Open Biol
Ellis C, Ward NL, Rice M, Ball NJ, Walle P, Najdek C, Kilinc D, Lambert JC, Chapuis J, Goult BT.   +9 more
europepmc   +1 more source

Stress, stress systems, and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly, Chayarndorn Phumsatitpong, Catherine E. Munro, Thomas C. Neylan, Daniela Kaufer, Alexander J. Ehrenberg   +5 more
wiley   +1 more source

Correction: Ramadan, W.S.; Alkarim, S. Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer's Model. Cells 2021, 10, 3511. [PDF]

Cells
Ramadan WS, Alkarim S.
europepmc   +1 more source

Allele specific expression in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Allele‐specific expression (ASE), preferential expression of one allele at a heterozygous locus, is implicated in various brain diseases but remains largely uncharacterized in Alzheimer's disease (AD). METHODS We performed a genome‐wide characterization of ASE variants across seven brain regions of 2,231 AD and Control patients ...
Zishan Wang, Delowar Hossain, Judy Jiaru Wang, Varun R. Subramaniam, Bin Zhang, Minghui Wang, Kuan‐lin Huang   +6 more
wiley   +1 more source

Mapping cross‐domain drivers of Alzheimer's disease risk through integrated network analysis

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder with numerous known risk factors. Identification of which genetic factors are causal drivers is difficult due to the long disease prodrome in an inaccessible organ.
Gregory A Cary, Stephen Keegan, Jesse C Wiley, Jake Gockley, Robert R Butler III, Frank M Longo, Allan I Levey, Anna K Greenwood, Karina Leal, Gregory W Carter, for The Emory‐Sage‐SGC‐JAX TREAT‐AD Center   +10 more
wiley   +1 more source