Results 261 to 270 of about 175,143 (304)

RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein

Eden J, Kaufman JG, Cattin-Ortola J, Benedetti L, Nieuwenhuis B, Owen DJ, Lippincott-Schwartz J, Munro S, Gershlick DC.   +8 more
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Amyloid precursor protein and mitochondria

Current Opinion in Neurobiology, 2023
Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD.
Taylor A. Strope, Heather M. Wilkins
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Function of amyloid and amyloid protein precursor

Clinical Neurology and Neurosurgery, 1992
A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
R A, Roos, J, Haan
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The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins

Neurodegenerative Diseases, 2006
It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte, Anliker, Ulrike, Müller
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Amyloid precursor protein in Alzheimer's disease

2023
Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity.
Rupesh, Maurya, Gargi, Bhattacharjee, Khushal, Khambhati, Nisarg, Gohil, Priyanka, Singh, Indra, Mani, Dinh-Toi, Chu, Suresh, Ramakrishna, Pau-Loke, Show, Vijai, Singh   +9 more
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Regulation of Amyloid Precursor Protein Cleavage

Journal of Neurochemistry, 1999
Abstract : Multiple lines of evidence suggest that increased production and/or deposition of the β‐amyloid peptide, derived from the amyloid precursor protein, contributes to Alzheimer's disease. A growing list of neuro‐transmitters, growth factors, cytokines, and hormones have been shown to regulate amyloid precursor protein processing.
J, Mills, P B, Reiner
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Processing of Amyloid Precursor Protein and Amyloid Peptide Neurotoxicity

Current Alzheimer Research, 2008
Alzheimer's disease is characterized by the presence of two types of lesions in brain: neurofibrillary tangles and senile plaques. Intraneuronal neurofibrillary tangles are made of paired helical filaments containing hyperphosphorylated microtubule associated protein tau.
Pierrot, Nathalie, Octave, Jean-Noël
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Fermented papaya preparation attenuates β-amyloid precursor protein: β-amyloid–mediated copper neurotoxicity in β-amyloid precursor protein and β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells

Neuroscience, 2006
Recent studies indicate that the deposition of beta-amyloid (Abeta) is related in the pathogenesis of Alzheimer's disease (AD), but the underlying mechanism is still not clear. The abnormal interactions of Abeta with metal ions such as copper are implicated in the process of Abeta deposition and oxidative stress in AD brains.
J, Zhang, A, Mori, Q, Chen, B, Zhao
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β-Amyloid precursor is a PEST protein

Biochemical and Biophysical Research Communications, 1989
The beta-amyloid peptide is generated by proteolytic processing of a family of beta-amyloid precursor proteins. Here we report that beta-amyloid precursor proteins have a primary structure motif known as a PEST sequence, which is predictive of the class of most protease-sensitive rapidly turning over proteins.
R, Siman, G, Christoph
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