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RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein
Eden J +8 more
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Amyloid precursor protein and mitochondria
Current Opinion in Neurobiology, 2023Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD.
Taylor A. Strope, Heather M. Wilkins
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Function of amyloid and amyloid protein precursor
Clinical Neurology and Neurosurgery, 1992A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
R A, Roos, J, Haan
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The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins
Neurodegenerative Diseases, 2006It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte, Anliker, Ulrike, Müller
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Physiology and pharmacology of amyloid precursor protein
Pharmacology & Therapeutics, 2022Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in the brains of individuals with Alzheimer's disease (AD)-related pathologies. Aβ has been extensively investigated since the amyloid hypothesis in AD was proposed.
Yoonsuk, Cho +4 more
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Regulation of Amyloid Precursor Protein Cleavage
Journal of Neurochemistry, 1999Abstract : Multiple lines of evidence suggest that increased production and/or deposition of the β‐amyloid peptide, derived from the amyloid precursor protein, contributes to Alzheimer's disease. A growing list of neuro‐transmitters, growth factors, cytokines, and hormones have been shown to regulate amyloid precursor protein processing.
Julia Mills, Peter B Reiner
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Processing of Amyloid Precursor Protein and Amyloid Peptide Neurotoxicity
Current Alzheimer Research, 2008Alzheimer's disease is characterized by the presence of two types of lesions in brain: neurofibrillary tangles and senile plaques. Intraneuronal neurofibrillary tangles are made of paired helical filaments containing hyperphosphorylated microtubule associated protein tau.
Pierrot, Nathalie, Octave, Jean-Noël
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β-Amyloid precursor is a PEST protein
Biochemical and Biophysical Research Communications, 1989The beta-amyloid peptide is generated by proteolytic processing of a family of beta-amyloid precursor proteins. Here we report that beta-amyloid precursor proteins have a primary structure motif known as a PEST sequence, which is predictive of the class of most protease-sensitive rapidly turning over proteins.
R, Siman, G, Christoph
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